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Teaching Evolutionary Concepts in Elementary School
Charles Darwin would be pleased to know that elementary school children in states that have adopted the Next Generation Science Standards (NGSS) are expected to demonstrate their understanding of several core evolutionary concepts, including trait variation and inheritance, fossils and extinct organisms, common ancestry, natural selection, and adaptation. However, he might also wonder how this is accomplished in the demanding 21st-century science curriculum. In files linked to this article, we provide four lesson plans – with engaging examples, natural selection games, and other interactive activities – that were designed to cover the NGSS Disciplinary Core Ideas in evolutionary biology for grades 3–5, in two one-hour lessons. The lesson plans were developed by college students under the guidance of evolutionary biologists and in consultation with elementary school teachers, and then field tested in elementary school classrooms, as described in an accompanying research article
Tumor T1 Relaxation Time for Assessing Response to Bevacizumab Anti-Angiogenic Therapy in a Mouse Ovarian Cancer Model
Estimation of tuberculosis incidence at subnational level using three methods to monitor progress towards ending TB in India, 2015–2020
Objectives We verified subnational (state/union territory (UT)/district) claims of achievements in reducing tuberculosis (TB) incidence in 2020 compared with 2015, in India.Design A community-based survey, analysis of programme data and anti-TB drug sales and utilisation data.Setting National TB Elimination Program and private TB treatment settings in 73 districts that had filed a claim to the Central TB Division of India for progress towards TB-free status.Participants Each district was divided into survey units (SU) and one village/ward was randomly selected from each SU. All household members in the selected village were interviewed. Sputum from participants with a history of anti-TB therapy (ATT), those currently experiencing chest symptoms or on ATT were tested using Xpert/Rif/TrueNat. The survey continued until 30 Mycobacterium tuberculosis cases were identified in a district.Outcome measures We calculated a direct estimate of TB incidence based on incident cases identified in the survey. We calculated an under-reporting factor by matching these cases within the TB notification system. The TB notification adjusted for this factor was the estimate by the indirect method. We also calculated TB incidence from drug sale data in the private sector and drug utilisation data in the public sector. We compared the three estimates of TB incidence in 2020 with TB incidence in 2015.Results The estimated direct incidence ranged from 19 (Purba Medinipur, West Bengal) to 1457 (Jaintia Hills, Meghalaya) per 100 000 population. Indirect estimates of incidence ranged between 19 (Diu, Dadra and Nagar Haveli) and 788 (Dumka, Jharkhand) per 100 000 population. The incidence using drug sale data ranged from 19 per 100 000 population in Diu, Dadra and Nagar Haveli to 651 per 100 000 population in Centenary, Maharashtra.Conclusion TB incidence in 1 state, 2 UTs and 35 districts had declined by at least 20% since 2015. Two districts in India were declared TB free in 2020