Case Report on Conjunctivitis an Outbreak Disease in Dehradun India

On July, 2023, the head of a GDMC, Dehradun similar eye symptoms among the students. We investigated the cluster to confirm the diagnosis, identify potential exposures, and propose recommendations. We defined a case as redness/watering/discharge from any eye among the students15 July, 2023 to 20 august 2023. We actively searched for the cases and calculated attack rates. We drew epicurve by date of symptoms onset. We conducted a Prospective cohort study of students and staff. We collected data on potential exposures and calculated Risk Ratio (RR), 95% Confidence Interval (95%CI), and Population Attributable Risk (PAR)

Randomized Phase III Trial Comparing Epirubicin/ Doxorubicin Plus Docetaxel and Epirubicin/ Doxorubicin Plus Paclitaxel as First Line Treatment in Women with Advanced Breast Cancer

This study aimed to examine the efficacy of docetaxel plus epirubicin against docetaxel plus capecitabine as first-line therapy for women with advanced breast cancer (ABC). Patients with ABC who had not been treated in the past were split into two groups: those who received docetaxel and epirubicin (DE) on day 1 and those who received docetaxel and capecitabine (DC) on day 1 and twice daily on days 1-14 of each 21-day cycle. Prior neoadjuvant treatment with anthracyclines was permitted if it had been finished more than a year prior to enrolment. The study\u27s major aim was to evaluate the difference in time to disease progression (TTP). Median TTP for DE was 10.6 months and for DC it was 11.0 months (P = 0.7), with each arm treating 170 women. Using the RECIST criterion, we found that the rates of complete responses were higher in DC (61%) than in DE (11%), and that the rates of partial responses were lower in DC (40%) than in DE (45%) (P = 0.8). Grade 3-4 neutropenia was more common with DE than DC (57% vs. 46%, P = 0.07), as were febrile neutropenia (11% vs. 8%, P = 0.4), hand-foot syndrome (0% vs. 4%, P = 0.02), grade 2-3 anemia (20% vs. 7%, P = 0.001), and asthenia (12% vs. 6%, P = 0.09)

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It\u27s worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study\u27s authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease

Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

Neuroinflammation is a characteristic sign of a wide variety of neurodegenerative diseases, including Alzheimer\u27s and Parkinson\u27s, amongst others. Microglia, which are native immune cells found in the brain, become activated very quickly in response to a brain infection or injury. When microglia become overactivated, their production of pro-inflammatory and cytotoxic chemicals can become unregulated and uncontrolled, which is the primary cause of neuroinflammation. Microglia are principally responsible for neuroinflammation. As a result, the investigation of novel approaches to reduce neuroinflammatory reactions is an essential component of neurodegenerative disease treatment. In the research of brain inflammation, bacterial lipopolysaccharide is frequently used. This compound is responsible for the initiation of a number of significant cellular processes that significantly contribute to the pathophysiology of neuroinflammation

A Brief Description of Different Types of Cancers and Role of Some Herbs & Bioactive Compounds in Lung Cancer Management

Cancer immunotherapy has considerably raised patient survival rates and significantly improved patients\u27 quality of life in comparison to the gold standard of care, which includes chemotherapy, radiation therapy, and surgery. Immunotherapy has firmly established itself as a novel pillar of cancer care across the board, from the metastatic stage all the way through adjuvant and neoadjuvant treatment in a wide variety of cancer types. In this overview, the primary emphasis will be placed on the seminal moments in the history of cancer immunotherapy that prepared the way for the cutting-edge treatments that are available today. Cancer treatment that makes use of medicinal herbs and the phytocompounds that can be obtained from those herbs is becoming an increasingly attractive option. It has been demonstrated in a number of clinical studies that the use of herbal medicines in conjunction with conventional therapy can increase survival rates, immunological modulation, and quality of life (QOL) in patients who have cancer. In addition to this, we highlight the challenges and restrictions currently faced by cancer checkpoint immunotherapy as well as the cutting-edge research being conducted in the fields of individualized cancer vaccines, autoimmunity, the microbiome, the microenvironment of tumors, and metabolomics to find solutions to these problems. For hundreds of years, practitioners of traditional medicine have depended on treatments derived from plants. Many studies on their use have been carried out all over the world, and some of the findings have led to the development of medicines that are derived from plants. The global market for medicinal plant products is estimated to be worth more than one hundred billion dollars each year. This research investigates the role, contributions, and utility of medicinal plants in the context of the current strategic methods to disease prevention, notably lung cancer, which is a public health concern. The focus of this research is on the current strategic approaches to disease prevention

Recent Advancement in Ocular Drug Delivery System: A Systematic Review

Recent scientific and technological advancements have made ophthalmology a top priority for the study of therapeutic products, including the creation, preclinical testing, and clinical evaluation of novel medications, medical devices, and drug-medical device combinations. In order to decrease metabolism and elimination and increase residence time in ocular tissues and compartments, sustained-release drug delivery systems such as liposomes, micelles, nano-emulsions, nanoparticles with colloidal structures, and intraocular implants have been developed. Research is also being conducted in the area of cutting-edge medicines, including those based on gene or cell systems, both of which are considered high-risk products because to their intricate structures. Regarding the definition of drug (medicinal product) and recent changes in regulation, this article reviews recent advancements in ophthalmic drug, gene, and cellular delivery systems and related goods as well as breakthroughs in advanced therapeutic medicinal Products

Uses of AI in Field of Radiology- What is State of Doctor & Pateints Communication in Different Disease for Diagnosis Purpose

Over the course of the past ten years, there has been a rising interest in the application of AI in radiology with the goal of improving diagnostic practises. Every stage of the imaging workflow might potentially be improved by AI, beginning with the ordering of diagnostic procedures and ending with the distribution of data. One of the disadvantages of utilising AI in radiology is that it can disrupt the doctor-patient contact that takes place during the diagnostic procedure. This research synthesis examines how patients and clinicians engage with AI in the process of diagnosing cancer, brain disorders, gastrointestinal tract, and bone-related diseases. [S]ome of the diseases that are studied include cancer, brain disorders, and gastrointestinal tract.  Researchers began their investigation of several databases in 2021 and continued their work until 2023. Some of the databases that were examined include PubMed, Embase, Medline, Scopus, and PsycNet. The search terms "artificial intelligence" and "intelligence machine" as well as "communication," "radiology," and "oncology diagnosis" were utilised. It has been demonstrated that artificial intelligence can help medical professionals make more accurate diagnoses. Medical compliance can be enhanced with good training in doctor-patient diagnosis communication, and future research may assist boost patients\u27 trust by informing them of the benefits of AI. Both of these things are important for the delivery of quality medical care. GRAPHICAL ABSTRACT &nbsp

Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus

Some issues regarding the potential spread of monkeypox have arisen just as the international world is beginning to recover from the initial alarm that was caused by the probable spread of coronavirus disease 2019 (COVID-19). Despite the fact that parts of Africa have traditionally been more susceptible to monkeypox than other regions of the world, the majority of new cases that have been linked to the outbreak that began in 2022 have been reported in countries located in Europe and the western hemisphere. Despite the fact that a great number of organisations are working on contact-tracing activities at the moment, the origin of this outbreak is still unknown at this time. The monkeypox virus belongs to the family of viruses known as Poxviridae and the genus known as Orthopoxvirus. Following the eradication of smallpox across the globe in the 1970s, news of monkeypox caused widespread worry across the globe. Through vaccination with the smallpox virus, individuals were able to develop cross-immunity against monkeypox. After distribution of the smallpox vaccine was discontinued, the number of outbreaks of monkeypox rose. The monkeypox epidemic that occurred in the United States in 2003 was the first time that the disease gained extensive notice in the media. In spite of its name, the virus known as monkeypox is not transmitted by monkeys. Although a number of different kinds of rodents and other small mammals have been suggested as the primal hosts of the monkeypox virus, the virus\u27s true lineage is still a mystery. The virus that causes monkeypox was first identified in macaque monkeys, which is where the disease was first seen. When monkeypox does transfer from one person to another, it often does so through a person\u27s mucocutaneous lesions or through the respiratory droplets that they expel. However, this only happens very infrequently. However, supporting therapy can be given to reduce symptoms, and medications such tecovirimat may be administered in really severe cases. At this time, there is no specific treatment for patients who have infected the virus; however, supportive treatments can be given. It is debatable whether or not these treatments are successful in reducing symptoms because there are no concrete guidelines to follow in this regard

A Review on Most Opthalmic Viral Disease Conjunctivitivs (Eye Flu)

Ophthalmology clinics around the world see a lot of patients with conjunctivitis. Severe pain, impaired vision, and a painful pupillary reaction are all red flags for more serious intraocular disorders that should be taken into account while treating suspected cases of conjunctivitis. In patients with unusual findings and a chronic course, it is also important to have a complete medical and ocular history and do a comprehensive physical examination. The existence of a systemic ailment affecting the conjunctiva may be shown by concurrent findings on physical exam and pertinent history. The vast majority of cases of conjunctivitis still originate from viruses. Bacterial conjunctivitis is the second most prevalent cause of infectious conjunctivitis; however it is much less common than viral conjunctivitis. Nearly half of the population experiences allergic conjunctivitis, characterised by symptoms like itching, mucoid discharge, chemosis, and edoema of the eyelids. A patient with conjunctival irritation and discharge who has used preservative-containing eye drops regularly likely has toxic conjunctivitis. Timely diagnosis, proper classification of the various aetiologies, and suitable treatment are essential components of effective management of conjunctivitis

Recent Approaches of Intranasal to Brain Drug Delivery System

While the intranasal administration of drugs to the brain has been gaining both research attention and regulatory success over the past several years, key fundamental and translational challenges remain to fully leveraging the promise of this drug delivery pathway for improving the treatment of various neurological and psychiatric illnesses. In response, this review highlights the current state of understanding of the nose-to-brain drug delivery pathway and how both biological and clinical barriers to drug transport using the pathway can been addressed, as illustrated by demonstrations of how currently approved intranasal sprays leverage these pathways to enable the design of successful therapies. Moving forward, aiming to better exploit the understanding of this fundamental pathway, we also outline the development of nanoparticle systems that show improvement in delivering approved drugs to the brain and how engineered nanoparticle formulations could aid in breakthroughs in terms of delivering emerging drugs and therapeutics while avoiding systemic adverse effects