Knowledge of the art of governance: the Mughal and Ottoman empires in the early seventeenth century

This article seeks to reconstruct the prevailing concepts, images and principles that framed sovereign governance in the Mughal and Ottoman empires in the early seventeenth century. Little is known about the subject. To help fill the gap, two contemporaneous advice-to-kings treatises - one Mughal by 'Abd al-Haqq Dihlavī, one Ottoman by Koçi Bey - are analysed in juxtaposition. Such an analysis, never previously undertaken, is motivated and guided by a novel approach. In this approach, a model founded on near-universal conditions and problems is deployed within a regional perspective. The findings which result advance our understanding of the art of governance in the Mughal and Ottoman empires of the time. But they have a larger importance, too. They move us closer to achieving a break with the decline paradigm, whose logic still persists in mainstream interpretations. They also contribute to a more recent, and rapidly developing, interest in a region spanning much of South Asia and the Middle East that was formative for the global genesis of the modern world

Hepatitis C Associated B-cell Non-Hodgkin Lymphoma: Clinical Features and the Role of Antiviral Therapy

Abstract The link between chronic hepatitis C virus (HCV) infection and a subset of B-cell non-Hodgkin lymphomas (B-NHL) is strongly supported by epidemiological studies. Evidence demonstrating complete regression of lymphoma after antiviral treatments suggests possible chronic antigenic stimulation for the origin of B-NHL and provides evidence for a virus-mediated lymphomagenesis. B-NHL is a heterogeneous group of lymphomas with varied clinical presentation and may be indolent or aggressive. The optimal management of HCV related B-NHL is not clear. Antiviral treatment may be sufficient for low-grade lymphomas, but chemotherapy is necessary in patients with high grade lymphomas. Interferon (IFN)-based antiviral treatment regimens for HCV infection are limited by poor tolerance and suboptimal antiviral response. Recently approved novel direct acting antiviral (DAA) drugs are highly effective and safe. This has opened a new era for the treatment of HCV related B-NHL alone or in conjunction with chemotherapy. Treatment of HCV associated B-NHL should be performed in an interdisciplinary approach in close consultation with hematologist and hepatologist. In this review, we summarize data regarding clinical features and epidemiology of B-NHL and discuss novel therapeutic approaches, including DAAs, that may prove to be effective in the treatment of HCV associated lymphomas

Time course of collagen peak in bile duct-ligated rats

<p>Abstract</p> <p>Background</p> <p>One of the most useful experimental fibrogenesis models is the "bile duct-ligated rats". Our aim was to investigate the quantitative hepatic collagen content by two different methods during the different stages of hepatic fibrosis in bile duct-ligated rats on a weekly basis. We questioned whether the 1-wk or 4-wk bile duct-ligated model is suitable in animal fibrogenesis trials.</p> <p>Methods</p> <p>Of the 53 male Wistar rats, 8 (Group 0) were used as a healthy control group. Bile duct ligation (BDL) had been performed in the rest. Bile duct-ligated rates were sacrificed 7 days later in group 1 (10 rats), 14 days later in group 2 (9 rats), 21 days later in group 3(9 rats) and 28 days later in group 4 (9 rats). Eight rats underwent sham-operation (Sham). Hepatic collagen measurements as well as serum levels of liver enzymes and function tests were all analysed.</p> <p>Results</p> <p>The peak level of collagen was observed biochemically and histomorphometricly at the end of third week (P < 0.001 and P < 0.05). Suprisingly, collagen levels had decreased with the course of time such as at the end of fourth week (P < 0.01 and P < 0.05).</p> <p>Conclusion</p> <p>We have shown that fibrosis in bile duct-ligated rats is transient, i.e. reverses spontaneously after 3 weeks. This contrasts any situation in patients where hepatic fibrosis is progressive and irreversible as countless studies performed by many investigators in the same animal model.</p

Sovereign justice in precolonial maritime Asia: the case of the Mayor's court of Bombay, 1726–1798

From the beginning of the nineteenth century, remarkable developments in the realm of law were witnessed throughout the world. They expressed and paved the way for a new type of dispensation. For those parts of Asia and the Middle East with a substantial European presence, the legitimate rules, principles, and procedures for resolving disputes were progressively assimilated into systems of state-sanctioned legal pluralism. The process—at once gradual, charged, and punctuated—coincided with the initial consolidation of European imperial dominance and the emergence of Europe's modern global empires. Though these changes in the realm of law date from the nineteenth century, the European presence there had long preceded them. This was perhaps most notable in maritime Asia. The Europeans in this region tended to cluster in their factories or in certain quarters of the towns and cities dotting the Indian Ocean rim. Notwithstanding differences between, say, a Mocha and an Aceh in size, location, and form of government, all these settlements had one quality in common: each was able to profit from the traffic conducted along the coast or across the high seas. As for the sovereign justice on offer, the dispensation that governed it in early modern times was far removed from its later analogue. This stemmed in large part from the rationale and basis for the European presence. In particular, Europeans could not dominate maritime Asia's provincial and imperial powers, especially those located inland, and the great majority of those arriving from western Europe intended to return as soon as possible; despite some involvement in racketeering and other forms of surplus extraction—famously in attempts to introduce and enforce a system of passports in maritime transport and travel—their interests were mainly commercial, oriented towards trade and shipping; the indigenous populations remained on the whole large and resilient; and many of the skills and techniques vested in livelihoods long associated with the region retained their primacy. As a result, the only realistic option for Europeans in maritime Asia was to reconcile themselves to the prevailing order. And this they did, with most of the region's fundamentals, not least in the realm of law, continuing to develop along what were essentially indigenous lines

The informational fabric of eighteenth-century India and the Middle East: couriers, intermediaries and postal communication

Mundane knowledge of how information flows is essential for a proper understanding of large organisations and complex activities. It gives us valuable insights into the prevailing constraints of the era and the creative responses that enabled the demands of its cosmopolitan residents to be met. Though the sinews of communication have been a major topic of historical inquiry in recent decades, the focus has been decidedly uneven; much of the attention has been directed towards modern times and, for earlier periods, has been confined almost entirely to Europe, the western European empires and those sectors of the world's political economy in which Europeans had a stake. The rest of the world, in comparison, has been neglected, which may be seen clearly in the case of early modern India and the Middle East. This paper seeks to rectify the imbalance by offering a typology for making sense of how packages of low weight and high value were collected, transported and delivered over long distances within the region in the eighteenth century. While drawing on a wide range of sources, at the core of this analysis lies the correspondence of the headmen of a group—the Aiyangar pattamars—who specialised as couriers in pre-colonial southern India. Among the principal claims set forth are that there existed in this period two basic modes of private communication: in one, personal trust was paramount, in the other, the mode was effectively monopolised by recognised communities providing the necessary informational services within their cultural domain. These claims, if sustained, have major implications for current views on early modern India and the Middle East

A political sociology of empire: Mughal historians on the making of Mughal paramountcy

In this article, Mughal understandings of their own past are reconstructed from the standpoint of Mughal paramountcy in around 1700. That was the moment of the empire's greatest territorial reach, when it knew no peer nor threat. To reconstruct contemporary understandings of how this situation came about, histories of the Mughal empire composed by governing officials of the time are analysed using a novel approach rooted in a particular distinction between constants and contingencies. These understandings allow us to recapture the political sociology of empire as apprehended by the Mughal elites. The article's findings are of value for two reasons. Narrowly construed, they help fill a lacuna in mainstream views on Mughal historiography, traditionally dominated by Akbar and his reign, and imbued with the logic of decline (and of its corollary, the transition to colonialism). More broadly, because of the weight accorded to knowledge of the past in the formation of Mughal ruling elites, the findings provide fresh insights into the cognitive framework within which these elites operated at a moment recognized as highly significant then, and in retrospect

A world revealed: Islamic heartlands and India in the 18th century

The chance survival of a ‘postbag’ of letters reveals a lost world of merchants, pilgrims, bankers and scholars