Method for attaching a fused-quartz mirror to a conductive metal substrate

A fused-quartz mirror is attached to a conductive metal substrate by the following steps: tinning one surface of a fused-quartz mirror with a solder of substantially pure indium; tinning a metallic substrate with an indium eutectic alloy consisting essentially of indium bismuth, lead and tin having a melting point substantially below that of indium; heating the eutectic alloy to a temperature substantially above its melting point, but below that of the solder; floating the mirror into place, and subsequently cooling the alloy to a temperature substantially below its melting point

The estrogenic activity of phthalate esters in vitro

A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalate (BBP) > dibutyl phthalate (DBP) > diisobutyl phthalate (DIBP) > diethyl phthalate (DEP) > diisiononyl phthalate (DINP). Potencies ranged from approximately 1 x 10(6) to 5 x 10(7) times less than 17beta-estradiol. The phthalates that were estrogenic in the yeast screen were also mitogenic on the human breast cancer cells. Di(2-ethylhexyl) phthalate (DEHP) showed no estrogenic activity in these in vitro assays. A number of metabolites were tested, including mono-butyl phthalate, mono-benzyl phthalate, mono-ethylhexyl phthalate, mon-n-octyl phthalate; all were wound to be inactive. One of the phthalates, ditridecyl phthalate (DTDP), produced inconsistent results; one sample was weakly estrogenic, whereas another, obtained from a different source, was inactive. analysis by gel chromatography-mass spectometry showed that the preparation exhibiting estrogenic activity contained 0.5% of the ortho-isomer of bisphenol A. It is likely that the presence of this antioxidant in the phthalate standard was responsible for the generation of a dose-response curve--which was not observed with an alternative sample that had not been supplemented with o,p'-bisphenol A--in the yeast screen; hence, DTDP is probably not weakly estrogenic. The activities of simple mixtures of BBP, DBP, and 17beta-estradiol were assessed in the yeast screen. No synergism was observed, although the activities of the mixtures were approximately additive. In summary, a small number of phthalates are weakly estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vivo; this will require tests using different classes of vertebrates and different routes of exposure

Non-critical, near extremal AdS_6 background as a holographic laboratory of four dimensional YM theory

We study certain properties of the low energy regime of a theory which resembles four dimensional YM theory in the framework of a non-critical holographic gravity dual. We use for the latter the near extremal $AdS_6$ non-critical SUGRA. We extract the glueball spectra that associates with the fluctuations of the dilaton, one form and the graviton and compare the results to those of the critical near extremal $D4$ model and lattice simulations. We show an area law behavior for the Wilson loop and screening for the 't Hooft loop. The Luscher term is found to be $-{3/24}\frac {\pi}{L}$. We derive the Regge trajectories of glueballs associated with the spinning folded string configurations.Comment: 25 pages, JHEP styl

Non-critical supergravity (d>1) and holography

In this paper we investigate the supergravity equations of motion associated with non-critical ($d>1$) type II string theories that incorporate RR forms. Using a superpotential formalism we determine several classes of solutions. In particular we find analytic backgrounds with a structure of $AdS_{p+2}\times S^{d-p-2}$ and numerical solutions that asymptote a linear dilaton with a topology of $R^{1,d-3}\times R \times S^1$. The SUGRA solutions we have found can serve as anti holographic descriptions of gauge theories in a large $N$ limit which is different than the one of the critical gauge/gravity duality. It is characterized by N\rt \infty and $g_{YM}^2 N \sim 1$. We have made the first steps in analyzing the corresponding gauge theory properties like Wilson loops and the glue-ball spectra.Comment: 48 pages, JHEP style, 11 figure

Supersymmetry of Noncompact MQCD-like Membrane Instantons and Heat Kernel Asymptotics

We perform a heat kernel asymptotics analysis of the nonperturbative superpotential obtained from wrapping of an M2-brane around a supersymmetric noncompact three-fold embedded in a (noncompact) G_2-manifold as obtained in [1], the three-fold being the one relevant to domain walls in Witten's MQCD [2], in the limit of small "zeta", a complex constant that appears in the Riemann surfaces relevant to defining the boundary conditions for the domain wall in MQCD. The MQCD-like configuration is interpretable, for small but non-zero zeta as a noncompact/"large" open membrane instanton, and for vanishing zeta, as the type IIA D0-brane (for vanishing M-theory cicle radius). We find that the eta-function Seeley de-Witt coefficients vanish, and we get a perfect match between the zeta-function Seeley de-Witt coefficients (up to terms quadratic in zeta) between the Dirac-type operator and one of the two Laplace-type operators figuring in the superpotential. This is an extremely strong signature of residual supersymmetry for the nonperturbative configurations in M-theory considered in this work.Comment: 21 pages, LaTeX; v3: several clarifying remarks added, to appear in JHE

MARSI: metabolite analogues for rational strain improvement

Metabolite analogues (MAs) mimic the structure of native metabolites, can competitively inhibit their utilization in enzymatic reactions, and are commonly used as selection tools for isolating desirable mutants of industrial microorganisms. Genome-scale metabolic models representing all biochemical reactions in an organism can be used to predict effects of MAs on cellular phenotypes. Here, we present the Metabolite Analogues for Rational Strain Improvement (MARSI) framework. MARSI provides a rational approach to strain improvement by searching for metabolites as targets instead of genes or reactions. The designs found by MARSI can be implemented by supplying MAs in the culture media, enabling metabolic rewiring without the use of recombinant DNA technologies that cannot always be used due to regulations. To facilitate experimental implementation, MARSI provides tools to identify candidate MAs to a target metabolite from a database of known drugs and analogues

Polynomials, Riemann surfaces, and reconstructing missing-energy events

We consider the problem of reconstructing energies, momenta, and masses in collider events with missing energy, along with the complications introduced by combinatorial ambiguities and measurement errors. Typically, one reconstructs more than one value and we show how the wrong values may be correlated with the right ones. The problem has a natural formulation in terms of the theory of Riemann surfaces. We discuss examples including top quark decays in the Standard Model (relevant for top quark mass measurements and tests of spin correlation), cascade decays in models of new physics containing dark matter candidates, decays of third-generation leptoquarks in composite models of electroweak symmetry breaking, and Higgs boson decay into two tau leptons.Comment: 28 pages, 6 figures; version accepted for publication, with discussion of Higgs to tau tau deca

Nonperturbative Relations in N=2 SUSY Yang-Mills and WDVV equation

We find the nonperturbative relation between $\langle {\rm tr} \phi^2 \rangle$, $\langle {\rm tr} \phi^3\rangle$ the prepotential ${\cal F}$ and the vevs $\langle \phi_i\rangle$ in $N=2$ supersymmetric Yang-Mills theories with gauge group $SU(3)$. Nonlinear differential equations for ${\cal F}$ including the Witten -- Dijkgraaf -- Verlinde -- Verlinde equation are obtained. This indicates that $N=2$ SYM theories are essentially topological field theories and that should be seen as low-energy limit of some topological string theory. Furthermore, we construct relevant modular invariant quantities, derive canonical relations between the periods and investigate the structure of the beta function by giving its explicit form in the moduli coordinates. In doing this we discuss the uniformization problem for the quantum moduli space. The method we propose can be generalized to $N=2$ supersymmetric Yang-Mills theories with higher rank gauge groups.Comment: 12 pages, LaTex. Expanded version. New results, corrections, references and acknowledgements adde