Sequence alignment of fusion loop sequences of various strains of Ebola virus.

<p>Several conserved hydrophilic residues that might serve as potential pH sensors are highlighted: dark green—histidine, light green—threonine or glutamine, blue—lysine or arginine, red glutamate, orange—aspartates (not highly conserved). The sequence of Zaire EBOV (strain Mayinga-76) was used in this study and its residue numbers and a disulfide link that defines the fusion loop are indicated at the bottom. Basic residues are shown in blue, acidic residues in red, histidines in green, hydrophilic residues in light green, and non-conserved acidic/hydrophilic residues in orange.</p