Supplementary document for Three-fold information encryption based on polarization- and wavelength-multiplexed metasurfaces - 6735452.pdf

Supplemental documen

Dynamic magnetic resonance imaging method based on golden-ratio cartesian sampling and compressed sensing - Fig 3

<p>Point spread function comparison between (a) the golden-angle radial trajectory and (b) the proposed trajectory.</p

Determination of Pharmacokinetics of Chrysin and Its Conjugates in Wild-Type FVB and Bcrp1 Knockout Mice Using a Validated LC-MS/MS Method

Chrysin, a flavone found in many plants, is also available as a dietary supplement because of its reported anticancer activities. However, its bioavailability is very poor due to extensive phase II metabolism. The purpose of this study was to develop an UPLC-MS/MS method to simultaneously quantify chrysin and its phase II metabolites, and to determine its pharmacokinetics in FVB wild-type and Bcrp knockout (Bcrp1 −/−) mice. In addition, the role of BCRP in chrysin phase II disposition was further investigated in Caco-2 cells. The results showed that our sensitive and reproducible UPLC-MS/MS method was successfully applied to the pharmacokinetic study of chrysin in wild-type and Bcrp1 (−/−) FVB mice after oral administration (20 mg/kg). Although there was no significant change in systemic exposure of chrysin and its metabolites, it was found that the <i>T</i>_max for chrysin glucuronide was significantly shorter (<i>p</i> < 0.01) in Bcrp1-deficient mice. Furthermore, it was shown that inhibition of BCRP by Ko143 significantly reduced the efflux of chrysin sulfate in Caco-2 cells. In conclusion, BCRP had significant but less than expected impact on pharmacokinetics of chrysin and its conjugates, which were determined using a newly developed and validated LC-MS/MS method

Mean AP values of reconstructed images versus <i>N</i> with a temporal resolution of 10TR.

<p>Mean AP values of reconstructed images versus <i>N</i> with a temporal resolution of 10TR.</p

Mean AP values of the four methods with different temporal resolutions.

<p>Mean AP values of the four methods with different temporal resolutions.</p

“Shepp-Logan” phantom used in the simulation.

<p>“Shepp-Logan” phantom used in the simulation.</p

Additional file 1: of OPERA-LG: efficient and exact scaffolding of large, repeat-rich eukaryotic genomes with performance guarantees

Contains supplementary notes, figures and tables. (DOCX 2996 kb

Structural Distortion Controlled Spin-Crossover Behavior

Two mononuclear isomorphous complexes Fe­(<b>L1</b>)₂(SCN)₂ (<b>1</b>) and Fe­(<b>L2</b>)₂(SCN)₂ (<b>2</b>) [<b>L1</b> = 2-(pyridin-3-yl)-1<i>H</i>-imidazo­[4,5-<i>f</i>]­1,10-phenanthroline; <b>L2</b> = 2-(pyridin-4-yl)-1<i>H</i>-imidazo­[4,5-<i>f</i>]­1,10-phenanthroline] were obtained based on 1,10-phenanthroline derivatives. Due to the different structural distortion in the coordination geometries, <b>1</b> exhibits gradual spin transition around room temperature (<i>T</i>_1/2 = 315 K), while <b>2</b> displays a stable high-spin state

List of species within the experiment quadrats (1 m × 1 m) from 2006 to 2009.

<p>LHT, life history traits; A, annual plants; P, perennial plants; AB, annual & biennial. +, plants were present in samples. The individual contribution values of coverage (%) of the most abundant species are listed. The abbreviations of the individual species are used in the RDA analyses.</p><p>List of species within the experiment quadrats (1 m × 1 m) from 2006 to 2009.</p

Effects of experimental warming and N addition on the importance values of graminoid species (G) and forbs (F).

<p>Different lowercase letters above the columns indicate significant differences (P<0.05) among treatments every year. Data are reported as the mean ± SE (n = 6).</p