3,660 research outputs found
Mobile Communication Signatures of Unemployment
The mapping of populations socio-economic well-being is highly constrained by
the logistics of censuses and surveys. Consequently, spatially detailed changes
across scales of days, weeks, or months, or even year to year, are difficult to
assess; thus the speed of which policies can be designed and evaluated is
limited. However, recent studies have shown the value of mobile phone data as
an enabling methodology for demographic modeling and measurement. In this work,
we investigate whether indicators extracted from mobile phone usage can reveal
information about the socio-economical status of microregions such as districts
(i.e., average spatial resolution < 2.7km). For this we examine anonymized
mobile phone metadata combined with beneficiaries records from unemployment
benefit program. We find that aggregated activity, social, and mobility
patterns strongly correlate with unemployment. Furthermore, we construct a
simple model to produce accurate reconstruction of district level unemployment
from their mobile communication patterns alone. Our results suggest that
reliable and cost-effective economical indicators could be built based on
passively collected and anonymized mobile phone data. With similar data being
collected every day by telecommunication services across the world,
survey-based methods of measuring community socioeconomic status could
potentially be augmented or replaced by such passive sensing methods in the
future
Influence of chromophores on quarternary structure of phycobiliproteins from the cyanobacterium, Mastigocladus laminosus
Chromophores of C-phycocyanin and phycoerythrο-cyanin have been chemically modified by reduction to
rubins , bleaching , photoisomerization , or perturbation
with bulky substituents. Pigments containing modified
chromophores, or hybrids containing modified and unmodified chromophores in individual protomers have been prepared. All modifications inhibit the association of the
(aß)-protomers of these pigments to higher aggregates. The
results demonstrate a pronounced effect of the state of
the chromophores on biliprotein quaternary structure. It
may be important in phycobi1isome assembly , and also in
the dual function of biliproteins as (i) antenna pigments
for photosynthesis and (ii) reaction centers for photomor-phogenesis
Prediction of prostate cancer Gleason score upgrading from biopsy to radical prostatectomy using pre-biopsy multiparametric MRI PIRADS scoring system
An elementary stringy estimate of transport coefficients of large temperature QCD
Modeling QCD at large temperature with a simple holographic five dimensional
theory encoding minimal breaking of conformality, allows for the calculation of
all the transport coefficients, up to second order, in terms of a single
parameter. In particular, the shear and bulk relaxation times are provided. The
result follows by deforming the AdS background with a scalar dual to a
marginally relevant operator, at leading order in the deformation parameter.Comment: 11 pages; v2: comments and references adde
Nuclear Receptor SHP Activates miR-206 Expression via a Cascade Dual Inhibitory Mechanism
MicroRNAs play a critical role in many essential cellular functions in the mammalian species. However, limited information is available regarding the regulation of miRNAs gene transcription. Microarray profiling and real-time PCR analysis revealed a marked down-regulation of miR-206 in nuclear receptor SHP−/− mice. To understand the regulatory function of SHP with regard to miR-206 gene expression, we determined the putative transcriptional initiation site of miR-206 and also its full length primary transcript using a database mining approach and RACE. We identified the transcription factor AP1 binding sites on the miR-206 promoter and further showed that AP1 (c-Jun and c-Fos) induced miR-206 promoter transactivity and expression which was repressed by YY1. ChIP analysis confirmed the physical association of AP1 (c-Jun) and YY1 with the endogenous miR-206 promoter. In addition, we also identified nuclear receptor ERRγ (NR3B3) binding site on the YY1 promoter and showed that YY1 promoter was transactivated by ERRγ, which was inhibited by SHP (NROB2). ChIP analysis confirmed the ERRγ binding to the YY1 promoter. Forced expression of SHP and AP1 induced miR-206 expression while overexpression of ERRγ and YY1 reduced its expression. The effects of AP1, ERRγ, and YY1 on miR-206 expression were reversed by siRNA knockdown of each gene, respectively. Thus, we propose a novel cascade “dual inhibitory” mechanism governing miR-206 gene transcription by SHP: SHP inhibition of ERRγ led to decreased YY1 expression and the de-repression of YY1 on AP1 activity, ultimately leading to the activation of miR-206. This is the first report to elucidate a cascade regulatory mechanism governing miRNAs gene transcription
Thermal photons in QGP and non-ideal effects
We investigate the thermal photon production-rates using one dimensional
boost-invariant second order relativistic hydrodynamics to find proper time
evolution of the energy density and the temperature. The effect of
bulk-viscosity and non-ideal equation of state are taken into account in a
manner consistent with recent lattice QCD estimates. It is shown that the
\textit{non-ideal} gas equation of state i.e behaviour
of the expanding plasma, which is important near the phase-transition point,
can significantly slow down the hydrodynamic expansion and thereby increase the
photon production-rates. Inclusion of the bulk viscosity may also have similar
effect on the hydrodynamic evolution. However the effect of bulk viscosity is
shown to be significantly lower than the \textit{non-ideal} gas equation of
state. We also analyze the interesting phenomenon of bulk viscosity induced
cavitation making the hydrodynamical description invalid. We include the
viscous corrections to the distribution functions while calculating the photon
spectra. It is shown that ignoring the cavitation phenomenon can lead to
erroneous estimation of the photon flux.Comment: 11 pages, 13 figures; accepted for publication in JHE
Broadband Reconfiguration of OptoMechanical Filters
We demonstrate broad-band reconfiguration of coupled photonic crystal
nanobeam cavities by using optical gradient force induced mechanical actuation.
Propagating waveguide modes that exist over wide wavelength range are used to
actuate the structures and in that way control the resonance of localized
cavity mode. Using this all-optical approach, more than 18 linewidths of tuning
range is demonstrated. Using on-chip temperature self-referencing method that
we developed, we determined that 20 % of the total tuning was due to
optomechanical reconfiguration and the rest due to thermo-optic effects.
Independent control of mechanical and optical resonances of our structures, by
means of optical stiffening, is also demonstrated
Thermodynamics of deformed AdS model with a positive/negative quadratic correction in graviton-dilaton system
By solving the Einstein equations of the graviton coupling with a real scalar
dilaton field, we establish a general framework to self-consistently solve the
geometric background with black-hole for any given phenomenological holographic
models. In this framwork, we solve the black-hole background, the corresponding
dilaon field and the dilaton potential for the deformed AdS model with a
positive/negative quadratic correction. We systematically investigate the
thermodynamical properties of the deformed AdS model with a positive and
negative quadratic correction, respectively, and compare with lattice QCD on
the results of the equation of state, the heavy quark potential, the Polyakov
loop and the spatial Wilson loop. We find that the bulk thermodynamical
properties are not sensitive to the sign of the quadratic correction, and the
results of both deformed holographic QCD models agree well with lattice QCD
result for pure SU(3) gauge theory. However, the results from loop operators
favor a positive quadratic correction, which agree well with lattice QCD
result. Especially, the result from the Polyakov loop excludes the model with a
negative quadratic correction in the warp factor of .Comment: 26 figures,36 pages,V.3: an appendix,more equations and references
added,figures corrected,published versio
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-α2β and Ribavirin therapy. The adrenal deterioration during the treatment course was observed closely with 24-hour salivary profiles and 250 μg adrenocorticotropin stimulation tests using parallel serum and salivary cortisol concentrations. A number of possible pathogenic mechanisms are discussed, and the controversy over its management is emphasized
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