E-learning : Student’s Perception of Online Learning in Hospitality Programs

Information technology has permeated into nearly every aspect of our life. With the advance of information technology e-learning has gradually replaced the traditional form of education. The globalized information economy and its market place are pushing educators to reshape higher education around the world. Whether they are a nation, a company, or an individual, all recognize that the real competitive advantages are likely to come from a well-educated mind in this knowledge-based economy. All these factors make higher education put efforts to redefine the measures of quality and also to better understand students’ needs while being aware of a consumer-oriented concept in market places. The goal of this study was to investigate the factors that influence student satisfaction and loyalty. In doing so, this study explored the relationships among perceived quality, perceived usefulness, satisfaction, and loyalty. One of critical findings of the study is that certain types of interaction quality in online earning course have mediation effects on student satisfaction as Hiltz (1994) suggested on the Online Interaction learning Theory

Contextual Factors that Influence Learning Effectiveness: Hospitality Students’ Perspectives

The need for ensuring the quality of e-learning in higher education has been growing with the rapid development and increasing popularity of e-learning. While several researchers have focused on the comparison of the effectiveness of e-learning with that of face-to-face learning, few empirical studies have been conducted on students’ learning along with student satisfaction which is one of good measures of learning effectiveness. Focusing on Hospitality area, this study, investigates the relationship between the perceived quality of online learning course and student outcome as well as student satisfaction. Students of four year public research universities offering online hospitality courses will be invited for this study. The findings will help not only understand students\u27 needs but also enhance online instructional practices and learning environments in hospitality programs

Exploring Key Determinants of Faculty’s Satisfaction with E-Learning Instructions

Abstract Innovations in e-learning technologies point toward a revolution in education, allowing learning to be individualized, enhancing students’ interactions with others, and transforming the role of the teacher. While the success of e-learning depends heavily on the satisfaction of students and available technologies, satisfaction on the part of the instructor, as a facilitator of learning rather than just a distributor of content, is also important and serves as one of the critical measures for the assessment of effectiveness of programs. In this vein, the purpose of this study is to identify the moderator factors that affect the satisfaction of online faculty in hospitality programs

E-learning: Student’s Perception of Online Learning in Hospitality Programs

Information technology has permeated into nearly every aspect of our life. With the advance of information technology e-learning has gradually replaced the traditional form of education. The globalized information economy and its market place are pushing educators to reshape higher education around the world. Whether they are a nation, a company, or an individual, all recognize that the real competitive advantages are likely to come from a well-educated mind in this knowledge-based economy. All these factors make higher education put efforts to redefine the measures of quality and also to better understand students’ needs while being aware of a consumer-oriented concept in market places. The goal of this study was to investigate the factors that influence student satisfaction and loyalty. In doing so, this study explored the relationships among perceived quality, perceived usefulness, satisfaction, and loyalty. One of critical findings of the study is that certain types of interaction quality in online earning course have mediation effects on student satisfaction as Hiltz (1994) suggested on the Online Interaction learning Theory.</p

Hydroquinone-Derivatives Induce Cell Death in Chronic Myelogenous Leukemia

Hydroquinone (HQ) is a phenolic metabolite of benzene, which is used as a skin whitener. Insects synthesize this natural compound as a deterrent and mushrooms as a toxin. Pro-apoptotic effects of HQ were previously documented on various cancer cell types. Here we investigated the cell-death inducing mechanisms of this compound in chronic myeloid leukemia cell models

Petromurin C Induces Protective Autophagy and Apoptosis in FLT3-ITD-Positive AML: Synergy with Gilteritinib

Treatment of acute myeloid leukemia (AML) remains inefficient due to drug resistance and relapse, particularly in patients with FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD). Marine-derived natural products have recently been used for drug development against AML. We show in this study that petromurin C, which was isolated from the culture extract of the marine-derived fungus Aspergillus candidus KUFA0062, isolated from the marine sponge Epipolasis sp., induces early autophagy followed by apoptotic cell death via activation of the intrinsic cell death pathway concomitant with mitochondrial stress and downregulation of Mcl-1 in FLT3-ITD mutated MV4-11 cells. Moreover, petromurin C synergized with the clinically-used FLT3 inhibitor gilteritinib at sub-toxic concentrations. Altogether, our results provide preliminary indications that petromurin C provides anti-leukemic effects alone or in combination with gilteritinib

Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477

International audienceAplysinopsins are a class of marine indole alkaloids that exhibit a wide range of biological activities. Although both the indole and N-benzyl moieties of aplysinopsins are known to possess antiproliferative activity against cancer cells, their mechanism of action remains unclear. Through in vitro and in vivo proliferation and viability screening of newly synthesized aplysinopsin analogs on myelogenous leukemia cell lines and zebrafish toxicity tests, as well as analysis of differential toxicity in noncancerous RPMI 1788 cells and PBMCs, we identified EE-84 as a promising novel drug candidate against chronic myeloid leukemia. This indole derivative demonstrated drug-likeness in agreement with Lipinski’s rule of five. Furthermore, EE-84 induced a senescent-like phenotype in K562 cells in line with its cytostatic effect. EE-84-treated K562 cells underwent morphological changes in line with mitochondrial dysfunction concomitant with autophagy and ER stress induction. Finally, we demonstrated the synergistic cytotoxic effect of EE-84 with a BH3 mimetic, the Mcl-1 inhibitor A-1210477, against imatinib-sensitive and resistant K562 cells, highlighting the inhibition of antiapoptotic Bcl-2 proteins as a promising novel senolytic approach against chronic myeloid leukemia

Unaromatized Tetrahydrobenzimidazole Synthesis from p -Benzoquinone and N -Arylamidines and their Cytotoxic Potential

International audienc

Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease

Serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central nervous system. However, serotonin in the peripheral system is associated with obesity and fatty liver disease. Because serotonin cannot cross the blood-brain barrier (BBB), we focused on identifying new tryptophan hydroxylase type I (TPH1) inhibitors that act only in peripheral tissues for treating obesity and fatty liver disease without affecting the central nervous system. Structural optimization inspired by para-chlorophenylalanine (pCPA) resulted in the identification of a series of oxyphenylalanine and heterocyclic phenylalanine derivatives as TPH1 inhibitors. Among these compounds, compound 18i with an IC50 value of 37 nM was the most active in vitro. Additionally, compound 18i showed good liver microsomal stability and did not significantly inhibit CYP and Herg. Furthermore, this TPH1 inhibitor was able to actively interact with the peripheral system without penetrating the BBB. Compound 18i and its prodrug reduced body weight gain in mammals and decreased in vivo fat accumulation