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A genetic and computational approach to structurally classify neuronal types
The importance of cell types in understanding brain function is widely appreciated but only a tiny fraction of neuronal diversity has been catalogued. Here, we exploit recent progress in genetic definition of cell types in an objective structural approach to neuronal classification. The approach is based on highly accurate quantification of dendritic arbor position relative to neurites of other cells. We test the method on a population of 363 mouse retinal ganglion cells. For each cell, we determine the spatial distribution of the dendritic arbors, or “arbor density” with reference to arbors of an abundant, well-defined interneuronal type. The arbor densities are sorted into a number of clusters that is set by comparison with several molecularly defined cell types. The algorithm reproduces the genetic classes that are pure types, and detects six newly clustered cell types that await genetic definition
Isotropic three-dimensional gap in the iron-arsenide superconductor LiFeAs from directional heat transport measurements
The thermal conductivity k of the iron-arsenide superconductor LiFeAs (Tc ~
18K) was measured in single crystals at temperatures down to T~50mK and in
magnetic fields up to H=17T, very close to the upper critical field Hc2~18T.
For both directions of the heat current, parallel and perpendicular to the
tetragonal c-axis, a negligible residual linear term k/T is found as T ->0,
revealing that there are no zero-energy quasiparticles in the superconducting
state. The increase in k with magnetic field is the same for both current
directions and it follows closely the dependence expected for an isotropic
superconducting gap. There is no evidence of multi-band character, whereby the
gap would be different on different Fermi-surface sheets. These findings show
that the superconducting gap in LiFeAs is isotropic in 3D, without nodes or
deep minima anywhere on the Fermi surface. Comparison with other iron-pnictide
superconductors suggests that a nodeless isotropic gap is a common feature at
optimal doping (maximal Tc).Comment: 4 pages, 3 figure
Inhaled Corticosteroids and Placebo Treatment Effects in Adult Patients With Cough : A Systematic Review and Meta-analysis
Copyright © 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.Peer reviewedPublisher PD
Prospective study of oncologic outcomes after laparoscopic modified complete mesocolic excision for non-metastatic right colon cancer (PIONEER study): study protocol of a multicentre single-arm trial
Abstract
Background
The introduction of complete mesocolic excision (CME) with central vascular ligation (CVL) for right-sided colon cancer has improved the oncologic outcomes. Recently, we have introduced a modified CME (mCME) procedure that keeps the same principles as the originally described CME but with a more tailored approach. Some retrospective studies have reported the favourable oncologic outcomes of laparoscopic mCME for right-sided colon cancer; however, no prospective multicentre study has yet been conducted.
Methods
This study is a multi-institutional, prospective, single-arm study evaluating the oncologic outcomes of laparoscopic mCME for adenocarcinoma arising from the right side of the colon. A total of 250 patients will be recruited from five tertiary referral centres in South Korea. The primary outcome of this study is 3-year disease-free survival. Secondary outcome measures include 3-year overall survival, incidence of surgical complications, completeness of mCME, and distribution of metastatic lymph nodes. The quality of laparoscopic mCME will be assessed on the basis of photographs of the surgical specimen and the operation field after the completion of lymph node dissection.
Discussion
This is a prospective multicentre study to evaluate the oncologic outcomes of laparoscopic mCME for right-sided colon cancer. To the best of our knowledge, this will be the first study to prospectively and objectively assess the quality of laparoscopic mCME. The results will provide more evidence about oncologic outcomes with respect to the quality of laparoscopic mCME in right-sided colon cancer.
Trial registration
ClinicalTrials.gov ID:
NCT03992599
(June 20, 2019). The posted information will be updated as needed to reflect protocol amendments and study progress
Tuning orbital-selective phase transitions in a two-dimensional Hund's correlated system
Hund's rule coupling () has attracted much attention recently for
its role in the description of the novel quantum phases of multi orbital
materials. Depending on the orbital occupancy, can lead to various
intriguing phases. However, experimental confirmation of the orbital occupancy
dependency has been difficult as controlling the orbital degrees of freedom
normally accompanies chemical inhomogeneities. Here, we demonstrate a method to
investigate the role of orbital occupancy in related phenomena
without inducing inhomogeneities. By growing SrRuO monolayers on various
substrates with symmetry-preserving interlayers, we gradually tune the crystal
field splitting and thus the orbital degeneracy of the Ru \textit{t_2_g$}$
orbitals. It effectively varies the orbital occupancies of two-dimensional (2D)
ruthenates. Via in-situ angle-resolved photoemission spectroscopy, we observe a
progressive metal-insulator transition (MIT). It is found that the MIT occurs
with orbital differentiation: concurrent opening of a band insulating gap in
the $\textit{d$_x_y} band and a Mott gap in the
\textit{d_x_/_z} bands. Our study provides an effective
experimental method for investigation of orbital-selective phenomena in
multi-orbital materials
Small anisotropy of the lower critical field and -wave two-gap feature in single crystal LiFeAs
The in- and out-of-plane lower critical fields and magnetic penetration
depths for LiFeAs were examined. The anisotropy ratio is
smaller than the expected theoretical value, and increased slightly with
increasing temperature from 0.6 to . This small degree of anisotropy
was numerically confirmed by considering electron correlation effect. The
temperature dependence of the penetration depths followed a power
law() below 0.3, with 3.5 for both and
. Based on theoretical studies of iron-based superconductors, these
results suggest that the superconductivity of LiFeAs can be represented by an
extended -wave due to weak impurity scattering effect. And the
magnitudes of the two gaps were also evaluted by fitting the superfluid density
for both the in- and out-of-plane to the two-gap model. The estimated values
for the two gaps are consistent with the results of angle resolved
photoemission spectroscopy and specific heat experiments.Comment: 10 pages, 5 figure
Comparison of extended reality and conventional methods of basic life support training: protocol for a multinational, pragmatic, noninferiority, randomised clinical trial (XR BLS trial)
Abstract
Background
Conventional cardiopulmonary resuscitation (CPR) training for the general public involves the use of a manikin and a training video, which has limitations related to a lack of realism and immersion. To overcome these limitations, virtual reality and extended reality technologies are being used in the field of medical education. The aim of this study is to explore the efficacy and safety of extended reality (XR)-based basic life support (BLS) training.
Methods
This study is a prospective, multinational, multicentre, randomised controlled study. Four institutions in 4 countries will participate in the study. A total of 154 participants will be randomly assigned to either the XR group or the conventional group stratified by institution and sex (1:1 ratio). Each participant who is allocated to either group will be sent to a separate room to receive training with an XR BLS module or conventional CPR training video. All participants will perform a test on a CPR manikin after the training. The primary outcome will be mean compression depth. The secondary outcome will be overall BLS performance, including compression rate, correct hand position, compression, and full release and hands-off time.
Discussion
Using virtual reality (VR) to establish a virtual educational environment can give trainees a sense of realism. In the XR environment, which combines the virtual world with the real world, trainees can more effectively learn various skills. This trial will provide evidence of the usefulness of XR in CPR education.
Trial registration
ClinicalTrials.gov
NCT04736888. Registered on 29 January 202
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