Cranial Radiation Therapy as Salvage in the Treatment of Relapsed Primary CNS Lymphoma

Primary central nervous system lymphoma (PCNSL) is a rare malignancy. Standard of care is upfront high-dose methotrexate (HD-MTX) chemotherapy, while cranial radiation is more commonly used in the salvage setting. In this retrospective study, we aimed to investigate the safety and efficacy of salvage cranial radiation in PCNSL. PCNSL patients who received upfront HD-MTX chemotherapy and salvage cranial radiation after treatment failure between 1995 and 2018 were selected. Radiological response to cranial radiation was assessed as per Response Assessment in Neuro-Oncology Criteria. Twenty one patients were selected (median age 59.9 years), with median follow-up of 19.9 months. Fourteen patients (66.7%) received a boost to the gross tumour volume (GTV). Four patients (19.0%) sustained grade ≥2 treatment-related neurotoxicity post-completion of cranial radiation. Of the 19 patients who had requisite MRI with gadolinium imaging available for Response Assessment in Neuro-Oncology (RANO) criteria assessment, 47.4% achieved complete response, 47.4% achieved partial response, and 5.3% of patients exhibited stable disease. Higher dose to the whole brain (>30 Gy) was associated with higher rate of complete response (63.6%) than lower dose (≤30 Gy, 37.5%), while boost dose to the gross disease was also associated with higher rate of complete response (61.5%) compared with no boost dose (33.3%). Median overall survival was 20.0 months. PCNSL patients who relapsed following upfront chemotherapy showed a high rate of response to salvage cranial radiation, especially in those receiving greater than 30 Gy to the whole brain and boost to gross disease

A Compact Self-Capacitance Sensing Analog Front-End for a Touch Detection in Low-Power Mode

A novel self-capacitance transition sensing method is presented for low-power touch detection using a capacitive touch-screen. While maintaining a voltage level, an additional electric charge is additionally required when a touch-input is newly added; the amount of charge is used for detection. Accordingly, the proposed current mirroring voltage-level regulation (CM-VLR) circuit senses the transition of self-capacitance of the touch-screen and detects motions of the touch-object. Only one CM-VLR cell is used to scan the entire touch-screen. Thus low-power readout and high integrated-circuit area efficiency are achieved. Moreover, the proposed self-capacitance sensing method does not require an offset-calibration step through a charge-sharing-based voltage generation and the offset-coverage capacitor. Fabricated in a 180-nm CMOS process, and the CM-VLR cell occupies 0.12 mm(2). At a 120-Hz report rate, the proposed analog front-end (AFE) detects touch-input at a 32-dB SNR while dissipating 2.1 mW.N

Myxofibrosarcoma directly invading superior vena cava causing obstruction successfully relieved by endovascular stent

Myxofibrosarcoma directly invading superior vena cava causing obstruction successfully relieved by endovascular sten

An Always-On 0.53-to-13.4 mW Power-Scalable Touchscreen Controller for Ultrathin Touchscreen Displays With Current-Mode Filter and Incremental Hybrid Delta Sigma ADC

This paper presents an always-on mutual-capacitive touchscreen controller (TSC)with a reconfigurable power consumption of 0.53-13.4 mW, frame rate of 1-120 Hz, and an SNR of 40.0-46.2 dB to support not only a normal sensing mode but also a low-power (LP) and an ultra-low - power (ULP) modes. For the LP and ULP modes, the power-frame rate scalability is realized by a frame rate controller, which turns off analog front-end (AFE) transmitter (TX) and receiver (RX) periodically. Moreover, the TSC improves an out-of-band noise attenuation by utilizing a sixth-order current-mode band-pass filter and second-order incremental hybrid delta-sigma (AL) modulator, providing an SNR up to 45.8 dB when the display on. The prototype TSC is fabricated in an 80-nm high-voltage CMOS technology with an active area of 4.873 mm(2).N