Data-Reserved Periodic Diffusion LMS With Low Communication Cost Over Networks

In this paper, we analyze diffusion strategies in which all nodes attempt to estimate a common vector parameter for achieving distributed estimation in adaptive networks. Under diffusion strategies, each node essentially needs to share processed data with predefined neighbors. Although the use of internode communication has contributed significantly to improving convergence performance based on diffusion, such communications consume a huge quantity of power in data transmission. In developing low-power consumption diffusion strategies, it is very important to reduce the communication cost without significant degradation of convergence performance. For that purpose, we propose a data-reserved periodic diffusion least-mean-squares (LMS) algorithm in which each node updates and transmits an estimate periodically while reserving its measurement data even during non-update time. By applying these reserved data in an adaptation step at update time, the proposed algorithm mitigates the decline in convergence speed incurred by most conventional periodic schemes. For a period p, the total cost of communication is reduced to a factor of 1/p relative to the conventional adapt-then-combine (ATC) diffusion LMS algorithm. The loss of combination steps in this process leads naturally to a slight increase in the steady-state error as the period p increases, as is theoretically confirmed through mathematical analysis. We also prove an interesting property of the proposed algorithm, namely, that it suffers less degradation of the steady-state error than the conventional diffusion in a noisy communication environment. Experimental results show that the proposed algorithm outperforms related conventional algorithms and, in particular, outperforms ATC diffusion LMS over a network with noisy links.11Ysciescopu

Point Mutation of Hoxd12 in Mice

Purpose: Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with chemical mutagen, N-ethyl-N-nitrosourea (ENU). We analyzed mutant mice exhibiting the specific microdactyly phenotype and examined the genes affected. Materials and Methods: We focused on phenotype characteristics including size, bone formation, and digit morphology of ENU-induced microdactyly mice. The expressions of several molecules were analyzed by genome-wide screening and quantitative real-time PCR to define the affected genes. Results: We report on limb phenotypes of an ENU-induced A-to-C mutation in the Hoxd12 gene, resulting in alanine-to-serine conversion. Microdactyly mice exhibited growth defects in the zeugopod and autopod, shortening of digits, a missing tip of digit I, limb growth affected, and dramatic increases in the expressions of Fgf4 and Lmx1b. However, the expression level of Shh was not changed Hoxd12 point mutated mice. Conclusion: These results suggest that point mutation rather than the entire deletion of Hoxd12, such as in knockout and transgenic mice, causes the abnormal limb phenotype in microdactyly mice. The precise nature of the spectrum of differences requires further investigation.link_to_subscribed_fulltex

Improving the Vertical Accuracy of Indoor Positioning for Emergency Communication

The emergency communication systems are undergoing a transition from the PSTN-based legacy system to an IP-based next generation system. In the next generation system, GPS accurately provides a user's location when the user makes an emergency call outdoors using a mobile phone. Indoor positioning, however, presents a challenge because GPS does not generally work indoors. Moreover, unlike outdoors, vertical accuracy is critical indoors because an error of few meters will send emergency responders to a different floor in a building. This paper presents an indoor positioning system which focuses on improving the accuracy of vertical location. We aim to provide floor-level accuracy with minimal infrastructure support. Our approach is to use multiple sensors available in today's smartphones to trace users' vertical movements inside buildings. We make three contributions. First, we present the elevator module for tracking a user's movement in elevators. The elevator module addresses three core challenges that make it difficult to accurately derive displacement from acceleration. Second, we present the stairway module which determines the number of floors a user has traveled on foot. Unlike previous systems that track users' foot steps, our stairway module uses a novel landing counting technique. Third, we present a hybrid architecture that combines the sensor-based components with minimal and practical infrastructure. The infrastructure provides initial anchor and periodic corrections of a user's vertical location indoors. The architecture strikes the right balance between the accuracy of location and the feasibility of deployment for the purpose of emergency communication

Diagnostic Approaches for Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia with a very poor prognosis. Accurate diagnosis of IPF is essential for good outcomes but remains a major medical challenge due to variability in clinical presentation and the shortcomings of existing diagnostic tests. Medical history collection is the first and most important step in the IPF diagnosis process; the clinical probability of IPF is high if the suspected patient is 60 years or older, male, and has a history of cigarette smoking. Systemic assessment for connective tissue disease is essential in the initial evaluation of patients with suspected IPF to identify potential causes of interstitial lung disease (ILD). Radiologic examination using high-resolution computed tomography plays a pivotal role in the evaluation of patients with ILD, and prone and expiratory computed tomography images can be considered. If additional tests such as surgical lung biopsy or transbronchial lung cryobiopsy are needed, transbronchial lung cryobiopsy should be considered as an alternative to surgical lung biopsy in medical centers with experience performing this procedure. Diagnosis through multidisciplinary discussion (MDD) is strongly recommended as MDD has become the cornerstone for diagnosis of IPF, and the scope of MDD has expanded to monitoring of disease progression and suggestion of appropriate treatment options

Intraoperative blood loss during different stages of scoliosis surgery: A prospective study

<p>Abstract</p> <p>Background</p> <p>There are a number of reasons for intraoperative blood loss during scoliosis surgery based on the type of approach, type of disease, osteopenia, and patient blood profile. However, no studies have investigated bleeding patterns according to the stage of the operation. The objective of this prospective study was to identify intraoperative bleeding patterns in different stages of scoliosis surgery.</p> <p>Methods</p> <p>We prospectively analyzed the estimated blood loss (EBL) and operation time over four stages of scoliosis surgery in 44 patients. The patients were divided into three groups: adolescent idiopathic (group 1), spastic neuromuscular (group 2) and paralytic neuromuscular (group 3). The per-level EBL and operation times of the groups were compared on a stage-by-stage basis. The bone marrow density (BMD) of each patient was also obtained, and the relationship between per-level EBL and BMD was compared using regression analysis.</p> <p>Results</p> <p>Per-level operation time was similar across all groups during surgical stage (p > 0.05). Per-level EBL was also similar during the dissection and bone-grafting states (p > 0.05). However, during the screw insertion stage, the per-level EBL was significantly higher in groups 2 and 3 compared to group 1 (p < 0.05). In the correction stage, per-level EBL was highest in group 3 (followed in order by groups 2 and 1) (p < 0.05). Preoperative BMD indicated that group 3 had the lowest bone quality, followed by groups 2 and 1 (in order), but the preoperative blood indices were similar in all groups. The differences in bleeding patterns in the screw insertion and correction stages were attributed to the poor bone quality of groups 2 and 3. Group 3 had the lowest bone quality, which caused loosening of the bone-screw interface during the correction stage and led to more bleeding. Patients with a T-score less than -2.5 showed a risk for high per-level EBL that was nine times higher than those with scores greater than -2.5 (p = 0.003).</p> <p>Conclusions</p> <p>We investigated the blood loss patterns during different stages of scoliosis surgery. Patients with poor BMD showed a risk of blood loss nine times higher than those with good BMD.</p

Acute gastritis associated with Epstein-Barr virus infection in a child

Infectious mononucleosis is Epstein-Barr virus (EBV) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. Gastrointestinal symptoms of EBV infection are nonspecific and occur rarely. EBV inducing acute gastrointestinal pathology is poorly recognized without suspicion. Careful consideration is needed to diagnose gastric involvement of EBV infection including gastric lymphoma, gastric cancer, and gastritis. A few recent cases of gastritis associated with EBV infection have been reported in adolescents and adults. However, there is no report of EBV-associated gastritis in early childhood. We experienced a rare case of 4-year-old girl with EBV gastritis confirmed by in situ hybridization

Suction Drain Tip Cultures in Predicting a Surgical Site Infection

Study Design Retrospective study. Purpose This study aimed to evaluate the prognostic value of drain tip culture after spinal surgery with a large number of participants. Overview of Literature The routine culture of suction drain tips that are placed in the surgical site of spinal surgeries has been performed in many institutions to detect surgical site infection (SSI). However, few reports have evaluated drain tip culture as a prognostic for SSI after spinal surgery. Materials and Methods This study retrospectively included 1,415 consecutive patients who underwent spinal surgery between January 2016 and December 2021. Patients diagnosed with infectious diseases were excluded. Prophylactic antibiotics were administered intraoperatively and 24 hours postoperatively. Drains were removed when the volume of postoperative fluid drainage was <50 mL and <100 mL in patients who underwent cervical and thoracic surgery and lumbar surgery in the preceding 24 hours, respectively, and cultures were made. We evaluated the correlation between the results of positive drain tip culture and SSI. Results Positive drain tip cultures were found in 51 cases (3.6%). SSI was identified in 34 cases (2.4%). The most frequently isolated microorganism was methicillin-resistant Staphylococcus epidermidis (61.8%). The sensitivity, specificity, and positive, and negative predictive values of drain tip culture were 50.0%, 97.4%, 32.1%, and 98.8%, respectively. The same bacteria were isolated from the surgical lesion in 16 of 17 SSI cases with a positive drain tip culture, thereby giving a bacteria matching rate between tissue culture and drain tip culture of 94.1%. The number of surgery levels, drain remaining period, and drain tip culture positivity were significantly increased in the SSI group. Conclusions Drain tip cultures might be useful for predicting SSI. Drain tip culture had a high positivity rate in the SSI group, and the coincidence rate for the causative pathogen was high