Haematological profile of sickle cell patients attending tertiary health care centre of southern odisha: a cross sectional study

Background: Sickle Cell Disorder (SCD) is a major health problem in India. After introduction of High-Performance Liquid Chromatography (HPLC) in MKCG Medical College, this study is first of its kind to describe haemoglobin variants of SCD. The aim of the study was to document haematological profile and pattern of haemoglobin variants in SCD patients.Methods: A Hospital based cross sectional study was conducted in Pathology department, MKCG medical college from October 2018 to May 2019. Sickle cell patients were included and patients in Sickle cell crisis or transfused with blood in last 3 months were excluded. Hematological indices were measured by Sysmex XT 2000i blood analyzer. Quantification of hemoglobin variants was done by HPLC. All data were analyzed using SPSS and Independent t-test was applied.Results: In this study 100 heterozygous and 116 homozygous cases were reported. In homozygous cases Hb were significantly low and MCV, MCH, RDW-CV were significantly high than heterozygous. Hb level was significantly lower in homozygous children. Hb F was significantly higher in children and homozygous cases. A significant positive correlation was seen between Hb and RBC in both cases.Conclusions: In homozygous cases moderate anaemia (microcytic hypochromic to normocytic hypochromic) with High Hb F and in heterozygous cases mild anaemia (microcytic hypochromic) dominated the haematological profile. Children were significantly more anaemic than adults in homozygous cases. Anisocytosis was significantly more in homozygous cases and pediatric age group. Average fetal Haemoglobin variant (Hb F) was significantly more in homozygous cases and lower in adult group in both homo and heterozygous cases

Respiratory health of the small scale dairy workers of urban Bhubaneswar, Odisha

Background: Human in close inhabitation with the cattle due to unventilated or inadequately ventilated establishments or inadequate living space, is always at a risk of sustaining infection from the cattle through different modes of disease transmission. This study hints at the increased incidences in respiratory infections among dairy workers in unorganized and small scale dairy farms due to amendable unhygienic practices. Methods: This survey was part of a larger study, conducted after ethics approval. Number of households involved in dairy work surveyed were 60. From every house, two members actively involved in dairy work were chosen and total respondents were 120. The study tool was a semi structured, mixed questionnaire. Results: 67.5% dairy workers self-reported occurrence of respiratory symptoms which included the complaints like cough,breathing difficulty on exertion. None of the dairy workers were vaccinated against any milk borne disease.Conclusion: The housing, civic amenities accessed by them and their awareness are probably the main reasons for wide variety of self perpetuated practices and deviations of standard requirement.Use of protective gear (gloves,caps,masks) should be strictly emphasized and popularized

Hygiene practices and awareness regarding Milk borne diseases (MBD) among dairy workers in unorganized urban settings of Bhubaneswar, Odisha, India

Background: Dairy work is thought to be predominantly a rural occupation. However, due to preferences we see a lot of urban residents consume fresh milk and hence, few people even in the urban areas take up cattle rearing as a cost effective profession. In the midst of much talked re-emerging diseases, caused by close habitation of animals and man, it would be very relevant to see living conditions of these populations and their hygiene practices in a space compromised scenario. In urban settings, they stay in close proximity and due to socioeconomic conditions, dairy workers in do not have appropriate amenities to tend on the cattle,clean or even scope for proper waste disposal. This in nutshell, leads to a disease enabling environment and the study aims at reviewing these living conditions. Besides, an assessment of health conditions of the dairy workers, their awareness regarding the milk borne diseases(MBD) was done. The findings helped generate recommendations for improvement of the profession and ultimately the quality of the milk. Objectives:1) Assess the hygiene practices during the stages of milk collection, storage and transport of milk among the sampled dairy workers from urban unorganized settings of Bhubaneswar. 2) Assess awareness of these workers regarding milk borne diseases. Methodology: This cross?sectional survey was part of a larger study and was conducted in unorganized sector of dairy workers in Bhubaneswar. 60 dairy households were surveyed and from each household, 2 members actively involved in dairy work were selected.The study tool was a semi structured, mixed questionnaire. The questionnaire had 3 sections; A was regarding household information(General sociodemographic details and Housing conditions for 60 HHs); B was to elicit the hygiene status of dairy workers(n=120) during each step of their work, their milk handling details during milk collection, storage and transportation; C had questions to assess the awareness of dairy worker regarding MBD. Results: Hygiene practices were very dismal at all points like milking,storage and transportation. Only 5.0% dairy households practised cleaning udder twice- prior to and after milking. Only 35% households kept the milk storage containers covered. 44.2% workers agreed that “MBD” is a community health problem. On general examination, pallor and icterus was found among workers. This strongly brings out that this group not only have the potential to be infected by zoonotic diseases, but can also transmit it to through the milk they are selling. A felt need is assessed for these workers in terms of creating standards of hygiene practices of cattle and milk handling and also impart them training on improving their occupational practices

Clinical Computing in Dentistry

Machines can seldom replace dentists in rightly handling the patients with optimistic human insight, considerations, creative planning and the monitoring of psychological acceptance and comfort experienced by any patient with the rehabilitation done. Intelligent computer related armamentarium with software can still help dental practitioners detect typical medical and dental signs and classify them according to certain rules more effectively. Based on image analysis algorithms, CAD systems can be used to look for signs of any tooth pathology that can be spotted in dental X-ray or cone beam computed tomography (CBCT) images. Applying computer vision algorithms to high-resolution CBCT slices helps to a great extent in diagnosing periapical lesions like granulomas, cysts, etc., and can help creating 3-D model of a root canal that reflects its shape with sufficient precision facilitating an optimum endodontic treatment planning. Hence, computer vision systems are already able to speed up the diagnostic process and provide a valuable second opinion in doubtful cases. This can lead a dentist and the patient thoroughly experience an optimistic acceptance and satisfaction of the treatment done

Estimation of the cardiovascular risk using World Health Organization/International Society of Hypertension (WHO/ISH) risk prediction charts in a rural population of South India

Background: World Health Organization/International Society of Hypertension (WHO/ISH) charts have been employed to predict the risk of cardiovascular outcome in heterogeneous settings. The aim of this research is to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among adults aged >40 years, utilizing the risk charts alone, and by the addition of other parameters. Methods: A cross-sectional study was performed in two of the villages availing health services of a medical college. Overall 570 subjects completed the assessment. The desired information was obtained using a pre- tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. The WHO/ISH risk prediction charts for the South-East Asian region was used to assess the cardiovascular risk among the study participants. Results: The study covered 570 adults aged above 40 years. The mean age of the subjects was 54.2 (±11.1) years and 53.3% subjects were women. Seventeen percent of the participants had moderate to high risk for the occurrence of cardiovascular events by using WHO/ISH risk prediction charts. In addition, CVD risk factors like smoking, alcohol, low High-Density Lipoprotein (HDL) cholesterol were found in 32%, 53%, 56.3%, and 61.5% study participants, respectively. Conclusion: Categorizing people as low (20%) risk is one of the crucial steps to mitigate the magnitude of cardiovascular fatal/non-fatal outcome. This cross-sectional study indicates that there is a high burden of CVD risk in the rural Pondicherry as assessed by WHO/ISH risk prediction charts. Use of WHO/ISH charts is easy and inexpensive screening tool in predicting the cardiovascular event

Nasopharyngeal pneumococcal carriage in South Asian infants:Results of observational cohort studies in vaccinated and unvaccinated populations

BACKGROUND: Nasopharyngeal pneumococcal carriage (NPC) is a prerequisite for invasive pneumococcal disease and reduced carriage of vaccine serotypes is a marker for the protection offered by the pneumococcal conjugate vaccine (PCV). The present study reports NPC during the first year of life in a vaccinated (with PCV10) cohort in Bangladesh and an unvaccinated cohort in India. METHODS: A total of 450 and 459 infants were recruited from India and Bangladesh respectively within 0-7 days after birth. Nasopharyngeal swabs were collected at baseline, 18 and 36 weeks after birth. The swabs were processed for pneumococcal culture and identification of serotypes by the Quellung test and polymerase chain reaction (PCR). An identical protocol was applied at both sites. RESULTS: Prevalence of NPC was 48% in the Indian and 54.8% in the Bangladeshi cohort at 18 weeks. It increased to 53% and 64.8% respectively at 36 weeks. The average prevalence of vaccine serotypes was higher in the Indian cohort (17.8% vs 9.8% for PCV-10 and 26.1% vs17.6% for PCV-13) with 6A, 6B, 19F, 23F, and 19A as the common serotypes. On the other hand, the prevalence of non-vaccine serotypes was higher (43.6% vs 27.1% for non-PCV13) in the Bangladeshi cohort with 34, 15B, 17F, and 35B as the common serotypes. Overcrowding was associated with increased risk of pneumococcal carriage. The present PCV-13 vaccine would cover 28%-30% and 47%-48% serotypes in the Bangladeshi and Indian cohorts respectively. CONCLUSIONS: South Asian infants get colonised with pneumococci early in infancy; predominantly vaccine serotypes in PCV naïve population (India) and non-vaccine serotypes in the vaccinated population (Bangladesh). These local findings are important to inform the public health policy and the development of higher valent pneumococcal vaccines