tet.folio: Eine Online-Plattform für die Produktion innovativer Lehr-Lern-Angebote

Als "Technology Enhanced Textbook", dem "Schulbuch der Zukunft" sowie als Verteilplattform für Interaktive Bildschirmexperimente (IBE) hat sich tet.folio in den letzten 10 Jahren zu einer universell einsetzbaren Lehr-Lern-Plattform entwickelt. Nach einer Übersicht interaktiver Beispiele aus unterschiedlichsten Fachgebieten stellen wir das Potential von tet.folio als Plattform für Autorinnen und Autoren vor. Basierend auf einfachen Konzepten werden mit tet.folio einheitlich erscheinende Lehr-Lern-Angebote umsetzbar. Effektiv herstellbar sind mit tet.folio neben individualisierten Inhalten auch entsprechende Formatvorlagen, mit denen Autorinnen und Autoren einheitlich gestaltete Lehr-Lern-Angebote schnell umsetzen können. Eine ansprechende Gestaltung der Angebote unterstützt die Fokussierung auf Lerninhalte. Die so erstellten Inhalte können, wenn gewünscht, auch als PDF im DIN-A4 Format oder für den Offline-Einsatz exportiert werden

Sarcinodes yeni, spec. nov., a new oenochromine moth from Taiwan (Insecta, Lepidoptera, Geometridae, Oenochrominae)

Volume: 22Start Page: 23End Page: 2

Thalassodes mohrae spec. nov., ein neuer Gr\ufcnspanner aus Sumatra (Insecta, Lepidoptera, Geometridae, Geometrinae)

Volume: 20Start Page: 277End Page: 28

To Agree Or Not To Agree: the Question of Gender Agreement in the International Code of Zoological Nomenclature

Volume: 25Start Page: 191End Page: 20

Oenospila kopperi, spec. nov., eine neue gr\ufcne Geometride aus Sumatra (Insecta, Lepidoptera, Geometridae, Geometrinae)

Volume: 24Start Page: 241End Page: 24

Congratulations to Prof. Dr. Hiroshi Inoue on his 85th birthday (8 July, 2002)162ST cNING, D. & A. HAUSMANN: Inouea, gen. nov., a new genus from the Philippines, with the type species I. cyclobalia (West, 1929), and two new species (Insecta, Lepidoptera, Geometridae, Ennominae)

Volume: 25Start Page: 163End Page: 17

Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations

Human cytomegalovirus (HCMV) is a pathogenic human herpesvirus associated with serious, potentially life-threatening symptoms in the immunocompromised or immunonaïve host. The limitations encountered by antiviral therapy options currently available include a narrow panel of accessible targets, the induction of viral drug resistance as well as severe drug dosage-mediated side-effects. Improved drug-targeting strategies to resolve these issues are the focus of our investigations. In particular, pharmaceutical kinase inhibitors (PKIs), either directed to host kinases or directed to the viral protein kinase pUL97, have been considered to overcome these restrictions. Recently, we reported the identification of a synergistic combination of two PKIs directed to host cyclin-dependent kinase 7 (CDK7) and viral CDK ortholog pUL97. Here, we substantiate these findings with the following results: (i) true drug synergy was exhibited by various chemical classes of PKI pairs directed to pUL97 and CDK7; (ii) no putative amplification of cytotoxicity by these drug combinations was observed; (iii) a reduction in drug dosage levels for synergistic combinations was defined on a quantitative basis and compared to monotreatments; (iv) the quantities of target proteins CDK7 and pUL97 expressed in HCMV-infected cells were assessed by confocal imaging, indicating a strong down-modulation of CDK7 levels as a result of synergistic drug treatment; (v) the functional importance of these target kinases, both binding to cyclin H, was illustrated by assessing HCMV replication under the viral genomic deletion of ORF-UL97 or cellular cyclin knock-out; (vi) new combinations of HCMV-specific drug synergy were demonstrated for solely host-directed treatments using PKIs against CDK2, CDK7, CDK8 and/or CDK9 and (vii) a triple PKI combination provided further support for the synergy approach. With these combined findings, this study highlights the potential of therapeutic drug combinations of approved, developmental and preclinical PKIs for expanding future options for anti-HCMV therapy

Sartre. Conscience et liberté

En l’honneur du centenaire de la naissance de Sartre, six philosophes des deux côtés du Rhin interrogent sa pensée dans ses fondements ontologiques et ses perspectives morales. La théorie sartrienne de la conscience, éclairée dans sa singularité à l’aide des traditions allemande et anglo-saxonne, les résistances à la thèse sartrienne de la liberté ainsi que la signification du projet d’une psychanalyse existentielle, font l’objet des trois premiers articles. Les trois suivants explorent les champs ouverts par les « conclusions » de L’Être et le Néant : la possibilité d’une approche métaphysique des phénomènes naturels et le questionnement moral. Ainsi, ces analyses visent à éclairer de manière critique le nœud de la pensée de Sartre, par lequel il demeure philosophiquement notre contemporain : l’articulation entre ontologie et morale

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for efficient viral replication. Previously, we reported that both kinases, vCDK/pUL97 and CDK7, interact with cyclin H, thereby achieving an enhanced level of kinase activity and overall functionality in viral replication. Here we provide a variety of novel results, as generated on a methodologically extended basis, and present a concept for the codetermination of viral replication efficiency through these kinase activities: (i) cyclin H expression, in various human cell types, is substantially upregulated by strains of HCMV including the clinically relevant HCMV Merlin; (ii) vCDK/pUL97 interacts with human cyclin H in both HCMV-infected and plasmid-transfected cell systems; (iii) a doxycycline-inducible shRNA-dependent knock-down (KD) of cyclin H significantly reduces pUL97 activity (qSox in vitro kinase assay); (iv) accordingly, pUL97 in vitro kinase activity is seen significantly increased upon addition of recombinant cyclin H; (v) as a point of specific importance, human CDK7 activity shows an increase by vCDK/pUL97-mediated trans-stimulation (whereas pUL97 is not stimulated by CDK7); (vi) phosphosite-specific antibodies indicate an upregulated CDK7 phosphorylation upon HCMV infection, as mediated through a pUL97-specific modulatory effect (i.e. shown by pUL97 inhibitor treatment or pUL97-deficient viral mutant); (vii) finally, an efficient KD of cyclin H in primary fibroblasts generally results in an impaired HCMV replication efficiency as measured on protein and genomic levels. These results show evidence for the codetermination of viral replication by vCDK/pUL97, cyclin H and CDK7, thus supporting the specific importance of cyclin H as a central regulatory factor, and suggesting novel targeting options for antiviral drugs