The Development of Constructivist Theory Computer Assisted Instruction CAI Simulation as a Teaching Material & Learning to Develop Analytical Skill for Prathomsueksa 3 Students

Objectives of this study were to 1) develop an effective constructivism computer assisted scenarios as teaching material for Prathomsuksa 3 (Year 3) that met the requirement of 80/80 criteria, 2) compare the analytical thinking skill of the students prior and after the course, 3) compare students’ academic achievement prior and after the course and 4) investigate students’ satisfaction towards the development. Samples of this study comprised of 20 students who were studying in Prathomsueksa 3, 2nd semester, academic year 2016 at Trimit Wittaya School and randomly selected using Cluster Random Sampling Technique. Research tools using in this study included 1) computer assisted scenarios which were developed based on constructivism theory, 2) 7 learning management plans covering period of 7 learning hours, 3) researcher created analytical thinking skill measuring 4 multiple-choice test comprising of 20 questions, 4) researcher created academic achievement 4 multiple-choice test, 5) researchers created students’ satisfaction measuring form using rating scale comprising of 10 rating statements. Percentile, Mean, Standard Deviation and Wilcoxon Signed Rank Test were employed to analyse the findings. Findings illustrated that 1) the effectiveness of constructivism computer assisted scenarios as teaching and/or learning material was 85.25 and 81.75 respectively, 2) students had higher analytical skill after taking the lessons at statistical significance level of.05, 3) students had higher academic achievement after taking the lesson at statistical significance level of.05 and 4) overall, students were satisfied with the development at the utmost level. In summary, the Constructivist Theory Computer Assisted Instruction CAI Simulation as teaching material is an effective tool which can be used to support the learning process in terms of reinforcing analytical thinking skill, increasing academic achievement and leaners’ satisfaction. This development is recommended to create more effective teaching process in various subjects

Navigating the challenges of the COVID-19 outbreak: Perspectives from the radiation oncology service in Singapore

10.1016/j.radonc.2020.03.030RADIOTHERAPY AND ONCOLOGY148189-19

Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).

10.1371/journal.pone.0224665PLoS One1411e0224665

Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).

AimTreatment strategies in laryngeal squamous cell cancer (LSCC) straddle the need for long term survival and tumor control as well as preservation of laryngeal function as far as possible. We sought to identify prognostic factors affecting LSCC outcomes in our population.MethodsClinical characteristics, treatments and survival outcomes of patients with LSCC were analysed. Baseline comorbidity data was collected and age-adjusted Charlson Comorbidity Index (aCCI) was calculated. Outcomes of overall survival (OS), progression-free survival (PFS) and laryngectomy-free survival (LFS) were evaluated.ResultsTwo hundred and fifteen patients were included, 170 (79%) underwent primary radiation/ chemoradiation and the remainder upfront surgery with adjuvant therapy where indicated. The majority of patients were male, Chinese and current/ex-smokers. Presence of comorbidity was common with median aCCI of 3. Median OS was 5.8 years. On multivariable analyses, high aCCI and advanced nodal status were associated with inferior OS (HR 1.24 per one point increase in aCCI, PConclusionIn our Asian population, the presence of comorbidities and high nodal status were associated with inferior OS, PFS and LFS whilst high T stage was associated with inferior LFS and OS

Exploring MRI based radiomics analysis of intratumoral spatial heterogeneity in locally advanced nasopharyngeal carcinoma treated with intensity modulated radiotherapy.

BackgroundWe hypothesized that spatial heterogeneity exists between recurrent and non-recurrent regions within a tumor. The aim of this study was to determine if there is a difference between radiomics features derived from recurrent versus non recurrent regions within the tumor based on pre-treatment MRI.MethodsA total of 14 T4NxM0 NPC patients with histologically proven "in field" recurrence in the post nasal space following curative intent IMRT were included in this study. Pretreatment MRI were co-registered with MRI at the time of recurrence for the delineation of gross tumor volume at diagnosis(GTV) and at recurrence(GTVr). A total of 7 histogram features and 40 texture features were computed from the recurrent(GTVr) and non-recurrent region(GTV-GTVr). Paired t-tests and Wilcoxon signed-rank tests were carried out on the 47 quantified radiomics features.ResultsA total of 7 features were significantly different between recurrent and non-recurrent regions. Other than the variance from intensity-based histogram, the remaining six significant features were either from the gray-level size zone matrix (GLSZM) or the neighbourhood gray-tone difference matrix (NGTDM).ConclusionsThe radiomic features extracted from pre-treatment MRI can potentially reflect the difference between recurrent and non-recurrent regions within a tumor and has a potential role in pre-treatment identification of intra-tumoral radio-resistance for selective dose escalation

The implementation of an advanced practice radiation therapy (APRT) program in Singapore

10.1016/j.tipsro.2021.02.002Technical Innovations and Patient Support in Radiation Oncology1763-7

Comparison of Circulating Tumour Cells and Circulating Cell-Free Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Undergoing Radiotherapy

10.1038/s41598-016-0006-3Scientific Reports611