Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats

Objective: The effects of gastroprotective properties of Spirulina platensis was investigated in acetic acid and ethanol induced ulcers in rats. Methods: Administration of 2 and 4mg/kg Spirulina platensis extract for 7 days. After day 7, oral administration of either 80% (v/v) ethanol or 6% (v/v) acetic acid. Control rats received saline or anti-ulcer drug omeprazole (20 mg/kg) prior to ulcer induction. Results: The extract inhibited the mean lesion score of acetic acid, 4.333 to 3.000. Whereas, for ethanol induced ulcers, the extract reduced the lesion scoring from 2.833 to 1.677. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. Spirulina platensis alone did not induce any ulcers in rats. Conclusions: These results suggested that Spirulina platensis has gastroprotective activity against ulcers induced by acetic acid and ethanol

Diuretic properties of Orthosiphon stamineus Benth.

Ethnopharmacological relevance: Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system. Aim of the study: To investigate the diuretic activity, to elucidate its possible mechanism and to evaluate the renal effects of Orthosiphon stamineus extract. Materials and methods: Water extracts were administered orally at doses of 5 and 10 mg/kg to Sprague-Dawley rats and the control groups were given commercial diuretic drugs either furosemide or hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 h. Blood was assayed for glucose, albumin, blood urea nitrogen (BUN) and creatinine. Results: O. stamineus extract exhibited dose-dependent diuretic activity. However, excretion of Na+ and Cl- was not markedly elevated, but urinary excretion of K+ was significantly increased. O. stamineus extracts slightly increased the serum BUN, creatinine and blood glucose level. Although these levels were statistically significant when compared to control, these levels were still within normal range. Conclusions: O. stamineus exhibited diuretic activity, but was less potent than furosemide and hydrochlorothiazide. Care should be taken when consuming this herb as slight increase of kidney function enzymes was recorded

Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study

Research Paper - Antinociceptive and antiinflammatory effects of Centella asiatica

OBJECTIVE: To evaluate the effects of Centella asiatica (CA) upon pain (antinociception) and inflammation in rodent models. MATERIAL AND METHODS: The antinociceptive activity of the water extract of CA (10, 30, 100 and 300 mg/kg) was studied using acetic acid-induced writhing and hot-plate method in mice. The antiinflammatory activity of CA was studied in rats by prostaglandin E2-induced paw edema. RESULTS: Water extract of CA revealed significant antinociceptive activity with both the models. The activity was statistically similar to aspirin but less potent than morphine. The CA extract also revealed significant antiinflammatory activity. This effect was statistically similar to the non-steroidal antiinflammatory drug, mefenamic acid. CONCLUSION: These results suggest that the water extract of CA possesses antinociceptive and antiinflammatory activities

Integration of ISO 45001 and project management institute's project management body of knowledge in construction project management

The integration of Occupational Health and Safety (OH&S) management and project management is not a new topic. However, with the new ISO 45001 international standards for OH&S management recently launched in 2018, a structured literature review is timely to assess the available body of knowledge, develop new ideas and deliberate future research inferences between ISO 45001 and Project Management Institute's (PMI) Project Management Body of Knowledge (PMBOK). A structured literature review was conducted using OH&S management keywords (ISO 45001, OSHA 18001, OHS, OH&S) against project management keyword (PMBOK), where the articles search was further refined, classified and analysed. This paper hence aims at appraising the conceptual integration of ISO 45001 and PMBOK in construction project management by investigating conceptual approaches on how ISO 45001 and PMBOK can be integrated and examining the current status of the existing literature on ISO 45001 and PMBOK. It was found that ISO 45001 is easier to overlay on PMBOK rather than the inverse. The paper also found that there is a lack of published literature on the integration of ISO 45001 and PMBOK and the inclusion of its predecessor which is OSHA 18001 was required. However, it is noted that even with a larger number of papers reviewed, the findings were largely inconsistent (heterogeneous) in terms of objectives, methodologies and results. Additional research into relationship model(s), as well as application of new technologies and digital application is recommended to complete the outlook for the integration of both systems