Achieving to some outranking relationships between post mining land uses through mined land suitability analysis

Adoption of most suitable post mining land use is a problem with multi-dimensional nature. There are so many factors in this problem which seriously influence on the decision judgments. Therefore, in this study a fifty-attribute framework for mined land suitability analysis including fifty numbers of economical, social, technical and mine site factors developed to be a foundation for this decision making problem. Analysis by an outranking multi-attribute decision-making technique, called elimination et choix traduisant la realite method, was taken into consideration because of its clear advantages on the field of mined land suitability analysis as compared with multi-attribute decision-making ranking techniques. Analytical hierarchy process method applied to calculate global weights of the attributes through pair wise comparison matrixes. The weights then passed to the elimination et choix traduisant la realit method so that the most efficient post mining land uses could be appointed through comparisons of pair-wise dominance relationships between alternatives. This approach applied to an illustrative example where, final results showed that, there were two non-dominated land-uses for the considered example; industrial and pasture. However by increasing indifference threshold limit, the non-dominated set reduced to a single alternative that was pasture land-use

Plasma PCSK9 level affects passively LAMP-2 expression; an evidence of transcription network

Free cholesterol accumulation in lysosomes is related to highly glycosylated membrane-protein functions, endogenous cholesterol synthesis and, LDL influx. The LAMP-1 and LAMP-2 are two lysosome proteins involved in cholesterol transport. The study aim was to investigate the associations between LAMP-2 expression level, LAMP-2/LAMP-1 expression ratio, blood PCSK9 protein and LDL-C values. One hundred twenty six healthy subjects were selected during a medical interview. The biochemical parameters were measured using routine laboratory techniques. The plasma PCSK9 level was identified by ELISA method. The LAMP-1/LAMP-2 expression levels were estimated by Real time qPCR technique. The PCSK9 and LAMP-2 expression networks were designed with Cytoscape software and, were enriched using transcription factor databases. Linear correlations were observed between PCSK9 and LDL-C levels (r = 0.34; p = 0.002) and, TC/HDL-C ratio (r = 0.35; p = 0.001). The LAMP-2 expression level and LAMP-2/LAMP-1 expression ratio were inversely related to LDL-C values (p = 0.02). The transcription factors were compartmented on the merged network and were strictly controlled the PCSK9 expression. The results suggested that the decreased LDL influx due to the increase of plasma PCSK9 level attenuates the LAMP-2 gene expression level. Furthermore, the merged network supported our findings that the LAMP-2 expression is not in relation to transcription factors involved with PCSK9 expression. © 2016 Elsevier Inc