Is building construction, as a social project organization and production system, complicated or complex?

A recent study of chaos in construction as a project production process and system has raised a valid question: Is construction production really complex or just complicated? More importantly, how do we know which one is the best characterization of construction? The answer to these questions is developed through a systematic story of the following topic headings: Comprehensive literature search of complicated and complex key words; development of complexity theory and complexity science – similarities and differences; behavior of complex systems – as opposite to ordered (complicated) systems; construction as a system – product (object), organization and process (social systems); implication on the project execution; new approaches to project management. Understanding complexity in construction management is important for two reasons: (1) to visualize how both complicated and complex traits exist in a construction project (an object as well as a social systems), and (2) to identify for stakeholders new types of managerial competencies and tools that reflect the understanding of complexity in construction

Reflective Practitioner: Grounding the Use of Instructional Technology in Principles, Teaching Philosophy, Course Goals and Disciplinary Values

Necessity, when assigned to teach a large introductory class in Construction Science, required I learn quickly the requisite instructional technology and its application. The title, “Reflective Practitioner” is an anachronism that does not capture the actual chronology: practice, finding a theory and applying it, and reflecting on the practice to find grounds for improvement. Practice was grounded in learning how to learn as the final objective of this course. In the process, objectives, goals, syllabus, assignments, projects, evaluations, lectures, and presentation techniques, had to be created. After teaching the course two semesters, I read the following and received coaching from the Center for Teaching Excellence. This provided an opportunity to reflect on what happened, clarify the theories, examine my teaching philosophy and further clarify the principles that inform the framework for the course. This paper reports on the result of this reflection and is based on the wisdom-of-practice scholarship (Weimer, 2006) therefore experience-based and subjective. This paper captures the flow along these major lines of t professional teaching practice, the motivation, and findings from decisions made in the process. Teaching as a dynamic process assures that there will be an evolution in time. This paper also captures the evolution of the course, the areas indicated for further research and more importantly advocates a method for teaching with instructional technology in need of verification by other institutions on its way to morph into a research scholarship with qualitative studies or quantifiable investigations of a dynamic process or a descriptive research

Spontaneous chirality via long-range electrostatic forces

We consider a model for periodic patterns of charges constrained over a cylindrical surface. In particular we focus on patterns of chiral helices, achiral rings or vertical lamellae, with the constraint of global electroneutrality. We study the dependence of the patterns' size and pitch angle on the radius of the cylinder and salt concentration. We obtain a phase diagram by using numerical and analytic techniques. For pure Coulomb interactions, we find a ring phase for small radii and a chiral helical phase for large radii. At a critical salt concentration, the characteristic domain size diverges, resulting in macroscopic phase segregation of the components and restoring chiral symmetry. We discuss possible consequences and generalizations of our model.Comment: Revtex, 4 pages, 4 figure

Vocabulary and Main Idea Reading Intervention Using Text Choice to Improve Content Knowledge and Reading Comprehension of Adolescents With Autism Spectrum Disorder.

This simultaneous replication single-case design study investigated a vocabulary and main idea intervention with an aspect of text choice provided to students with autism spectrum disorder (ASD). Five middle school students with ASD participated in two instructional groups taught by school-based personnel. Results were initially mixed. These results were followed by upward and stable trends, indicating a functional relationship between the independent and dependent variables. Social validity measures indicated that students appreciated the opportunity to make choices on text selection

BSRI (Building Sustainability Rating Index) for Building Construction

Sustainability has been defined by various institutions as “meeting the needs of the present without compromising the ability of future generations to meet their own needs”. This is a soft qualitative definition. It has also been defined as “taming the exponential growth of resource consumption and emissions generation while maintaining an exponential growth in affluence growth”. This is a quantitative definition. This paper provides a building sustainability rating system (BSRI) to assess sustainability impacts using both prescriptive (qualitative) assessment tools as well as performance (quantitative) rating tools of resource consumption and emissions generation. BSRI is easy to apply and focuses on macro (strategic design mission, vision and objectives) as well as micro (tactical) levels of the building stakeholder’s sustainability perspectives. The criteria and indices in BSRI are defined in order to reduce ambiguity, confusion and misunderstanding and create a standard for future integration of sustainability (GREEN) with BIM and LEAN platforms. The BSRI platform allows for adaptation and growth in knowledge of the sustainability issues such as embedded energy protocols, through the use of Bayesian Equations

Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae

Background: CYP725A4 catalyses the conversion of the first Taxol® precursor, taxadiene, to taxadiene-5α-ol (T5α-ol) and a range of other mono- and di-hydroxylated side products (oxygenated taxanes). Initially known to undergo a radical rebound mechanism, the recent studies have revealed that an intermediate epoxide mediates the formation of the main characterised products of the enzyme, being T5α-ol, 5(12)-oxa-3(11)-cyclotaxane (OCT) and its isomer, 5(11)-oxa-3(11)-cyclotaxane (iso-OCT) as well as taxadienediols. Besides the high side product: main product ratio and the low main product titre, CYP725A4 is also known for its slow enzymatic activity, massively hindering further progress in heterologous production of Taxol® precursors. Therefore, this study aimed to systematically explore the key parameters for improving the regioselectivity and activity of eukaryotic CYP725A4 enzyme in a whole-cell eukaryotic biocatalyst, Saccharomyces cerevisiae. / Results: Investigating the impact of CYP725A4 and reductase gene dosages along with construction of self-sufficient proteins with strong prokaryotic reductases showed that a potential uncoupling event accelerates the formation of oxygenated taxane products of this enzyme, particularly the side products OCT and iso-OCT. Due to the harmful effect of uncoupling products and the reactive metabolites on the enzyme, the impact of flavins and irons, existing as prosthetic groups in CYP725A4 and reductase, were examined in both their precursor and ready forms, and to investigate the changes in product distribution. We observed that the flavin adenine dinucleotide improved the diterpenoids titres and biomass accumulation. Hemin was found to decrease the titre of iso-OCT and T5α-ol, without impacting the side product OCT, suggesting the latter being the major product of CYP725A4. The interaction between this iron and the iron precursor, δ-Aminolevulinic acid, seemed to improve the production of these diterpenoids, further denoting that iso-OCT and T5α-ol were the later products. While no direct correlation between cellular-level oxidative stress and oxygenated taxanes was observed, investigating the impact of salt and antioxidant on CYP725A4 further showed the significant drop in OCT titre, highlighting the possibility of enzymatic-level uncoupling event and reactivity as the major mechanism behind the enzyme activity. To characterise the product spectrum and production capacity of CYP725A4 in the absence of cell growth, resting cell assays with optimal neutral pH revealed an array of novel diterpenoids along with higher quantities of characterised diterpenoids and independence of the oxygenated product spectra from the acidity effect. Besides reporting on the full product ranges of CYP725A4 in yeast for the first time, the highest total taxanes of around 361.4 ± 52.4 mg/L including 38.1 ± 8.4 mg/L of T5α-ol was produced herein at a small, 10-mL scale by resting cell assay, where the formation of some novel diterpenoids relied on the prior existence of other diterpenes/diterpenoids as shown by statistical analyses. / Conclusions: This study shows how rational strain engineering combined with an efficient design of experiment approach systematically uncovered the promoting effect of uncoupling for optimising the formation of the early oxygenated taxane precursors of Taxol®. The provided strategies can effectively accelerate the design of more efficient Taxol®-producing yeast strains

Comparative Analysis of Lean and Six Sigma in Building Construction: Benefits, Obstacles and Opportunities

Lean and Six Sigma have been recognized as innovative strategies that can be used to transform a firm’s management practices to a newer level. However, there is little guidance, or evidence indicating whether Lean or Six Sigma enhance the construction process significantly. This research fills this gap by investigating major obstacles, benefits and opportunities of Lean and Six Sigma as published in journal papers. A structured literature research (SLR) was performed to identify and compare lean and Six Sigma case studies and analyzed their findings and conclusions. This SLR resulted in a matrix that identifies the obstacles, benefits and opportunities of using Six Sigma and lean practices to assist industry practitioners adopt and implement these strategies