Perceptions of the COVID-19 vaccine and willingness to receive vaccination among health workers in Nigeria

Objectives The study aimed to examine health workers’ perceptions of the coronavirus disease 2019 vaccine in Nigeria and their willingness to receive the vaccine when it becomes available. Methods This multi-center cross-sectional study used non-probability convenience sampling to enroll 1,470 hospital workers aged 18 and above from 4 specialized hospitals. A structured and validated self-administered questionnaire was used for data collection. Data entry and analysis were conducted using IBM SPSS ver. 22.0. Results The mean age of respondents was 40±6 years. Only 53.5% of the health workers had positive perceptions of the COVID-19 vaccine, and only slightly more than half (55.5%) were willing to receive vaccination. Predictors of willingness to receive the COVID-19 vaccine included having a positive perception of the vaccine (adjusted odds ratio [AOR], 4.55; 95% confidence interval [CI], 3.50−5.69), perceiving a risk of contracting COVID-19 (AOR, 1.50; 95% CI, 1.25–3.98), having received tertiary education (AOR, 3.50; 95% CI, 1.40−6.86), and being a clinical health worker (AOR, 1.25; 95% CI, 1.01−1.68). Conclusion Perceptions of the COVID-19 vaccine and willingness to receive the vaccine were sub-optimal among this group. Educational interventions to improve health workers' perceptions and attitudes toward the COVID-19 vaccine are needed

Pulmonary hypertension among 5 to 18 year old children with sickle cell anaemia in Nigeria

<div><p>Background</p><p>Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sickle cell disease (SCD). Few studies on PHT in SCD have been carried out in children. This study aimed to estimate the prevalence of PHT in children with sickle cell anaemia (SCA) and determine its clinical and laboratory correlates.</p><p>Methods</p><p>In this cross sectional study, evaluation involved obtaining bio-data, history and physical examination findings in 175 SCA subjects with haemoglobin genotype SS aged 5 to 18 years and 175 age and sex matched controls with haemoglobin genotype AA. PHT was determined using peak Tricuspid Regurgitant Velocity (TRV) obtained from echocardiography as a marker. Complete blood count (CBC), lactate dehydrogenase (LDH) assay, reticulocyte count, foetal haemoglobin (HbF) estimation as well as Human Immunodeficiency Virus (HIV) I and II, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) screening were done for patients with SCA.</p><p>Results</p><p>The mean peak TRV of subjects with SCA and controls was 2.2 ± 0.4 m/s and 1.9 ± 0.3 m/s respectively and prevalence of PHT among children with SCA and controls was 22.9% and 2.3% respectively. PHT in SCA correlated negatively with body mass index, haematocrit and haemoglobin.</p><p>Conclusion</p><p>This study affirms that PHT prevalence is high in children with SCA in Nigeria. Cardiovascular examination for signs of PHT is recommended for children with SCA and if required, further echocardiographic assessment from as early as five years.</p></div

Flow chart showing recruitment of SCA subjects.

<p>Flow chart showing recruitment of SCA subjects.</p

Box plots depicting TRV values among SCA subjects and controls.

<p>Box plots depicting TRV values among SCA subjects and controls.</p

Comparison of laboratory parameters of SCA subjects with and without PHT.

<p>Comparison of laboratory parameters of SCA subjects with and without PHT.</p

Clinical findings of SCA subjects with and without PHT.

<p>Clinical findings of SCA subjects with and without PHT.</p

Demography and anthropometry of study population.

<p>Demography and anthropometry of study population.</p

Prevalence of pulmonary hypertension in SCA subjects and controls.

<p>Prevalence of pulmonary hypertension in SCA subjects and controls.</p

Independent variables associated with PHT.

<p>Independent variables associated with PHT.</p