2,490 research outputs found
Layer- and bulk roton excitations of 4He in porous media
We examine the energetics of bulk and layer-roton excitations of 4He in
various porous medial such as aerogel, Geltech, or Vycor, in order to find out
what conclusions can be drawn from experiments on the energetics about the
physisorption mechanism. The energy of the layer-roton minimum depends
sensitively on the substrate strength, thus providing a mechanism for a direct
measurement of this quantity. On the other hand, bulk-like roton excitations
are largely independent of the interaction between the medium and the helium
atoms, but the dependence of their energy on the degree of filling reflects the
internal structure of the matrix and can reveal features of 4He at negative
pressures. While bulk-like rotons are very similar to their true bulk
counterparts, the layer modes are not in close relation to two-dimensional
rotons and should be regarded as a third, completely independent kind of
excitation
Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.
Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database.
Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively.
Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors
First Detection of the White-Dwarf Cooling Sequence of the Galactic Bulge
We present Hubble Space Telescope data of the low-reddening Sagittarius
window in the Galactic bulge. The Sagittarius Window Eclipsing Extrasolar
Planet Search field (3'x3'), together with three more Advanced Camera for
Surveys and eight Wide Field Camera 3 fields, were observed in the F606W and
F814W filters, approximately every two weeks for two years, with the principal
aim of detecting a hidden population of isolated black holes and neutron stars
through astrometric microlensing. Proper motions were measured with an accuracy
of ~0.1 mas/yr (~4 km/s) at F606W~25.5 mag, and better than ~0.5 mas/yr (20
km/s) at F606W~28 mag, in both axes. Proper-motion measurements allowed us to
separate disk and bulge stars and obtain a clean bulge color-magnitude diagram.
We then identified for the first time a white dwarf (WD) cooling sequence in
the Galactic bulge, together with a dozen candidate extreme horizontal branch
stars. The comparison between theory and observations shows that a substantial
fraction of the WDs (30%) are systematically redder than the cooling tracks for
CO-core H-rich and He-rich envelope WDs. This evidence would suggest the
presence of a significant number of low-mass WDs and WD - main sequence
binaries in the bulge. This hypothesis is further supported by the finding of
two dwarf novae in outburst, two short-period (P < 1 d) ellipsoidal variables,
and a few candidate cataclysmic variables in the same field.Comment: 9 pages, 5 figures, accepted for publication on Ap
Spin Dynamics of La_2CuO_4 and the Two-Dimensional Heisenberg Model
The spin-lattice relaxation rate and the spin echo decay rate
for the 2D Heisenberg model are calculated using quantum Monte Carlo
and maximum entropy analytic continuation. The results are compared to recent
experiments on LaCuO, as well as predictions based on the non-linear
-model.Comment: Compressed & uuencoded Postscript file (4 pages with figures
Interstellar neutral helium in the heliosphere from IBEX observations. III. Mach number of the flow, velocity vector, and temperature from the first six years of measurements
We analyzed observations of interstellar neutral helium (ISN~He) obtained
from the Interstellar Boundary Explorer (IBEX) satellite during its first six
years of operation. We used a refined version of the ISN~He simulation model,
presented in the companion paper by Sokol_et al. 2015, and a sophisticated data
correlation and uncertainty system and parameter fitting method, described in
the companion paper by Swaczyna et al 2015. We analyzed the entire data set
together and the yearly subsets, and found the temperature and velocity vector
of ISN~He in front of the heliosphere. As seen in the previous studies, the
allowable parameters are highly correlated and form a four-dimensional tube in
the parameter space. The inflow longitudes obtained from the yearly data
subsets show a spread of ~6 degree, with the other parameters varying
accordingly along the parameter tube, and the minimum chi-square value is
larger than expected. We found, however, that the Mach number of the ISN~He
flow shows very little scatter and is thus very tightly constrained. It is in
excellent agreement with the original analysis of ISN~He observations from IBEX
and recent reanalyses of observations from Ulysses. We identify a possible
inaccuracy in the Warm Breeze parameters as the likely cause of the scatter in
the ISN~He parameters obtained from the yearly subsets, and we suppose that
another component may exist in the signal, or a process that is not accounted
for in the current physical model of ISN~He in front of the heliosphere. From
our analysis, the inflow velocity vector, temperature, and Mach number of the
flow are equal to lambda_ISNHe = 255.8 +/- 0.5 degree, beta_ISNHe = 5.16 +/-
0.10 degree, T_ISNHe = 7440 +/- 260 K, v_ISNHe = 25.8 +/- 0.4$ km/s, and
M_ISNHe = 5.079 +/- 0.028, with uncertainties strongly correlated along the
parameter tube.Comment: Updated reference
Spin Dependence of Correlations in Two-Dimensional Quantum Heisenberg Antiferromagnets
We present a series expansion study of spin-S square-lattice Heisenberg
antiferromagnets. The numerical data are in excellent agreement with recent
neutron scattering measurements. Our key result is that the correlation length
for S>1/2 strongly deviates from the exact T->0 (renormalized classical, or RC)
scaling prediction for all experimentally and numerically accessible
temperatures. We note basic trends with S of the experimental and series
expansion correlation length data and propose a scaling crossover scenario to
explain them.Comment: 5 pages, REVTeX file. PostScript file for the paper with embedded
figures available via WWW at http://xxx.lanl.gov/ps/cond-mat/9503143
Quantum Disordered Regime and Spin Gap in the Cuprate Superconductors
We discuss the crossover from the quantum critical, , to the quantum
disordered regime in high-T materials in relation to the experimental data
on the nuclear relaxation, bulk susceptibility, and inelastic neutron
scattering. In our scenario, the spin excitations develop a gap
well above T, which is supplemented by the
quasiparticle gap below T. The above experiments yield consistent estimates
for the value of the spin gap, which increases as the correlation length
decreases.Comment: 14 pages, REVTeX v3.0, PostScript file for 3 figures is attached,
UIUC-P-93-07-06
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
<p>Abstract</p> <p>Background</p> <p>In humans, the intestinal microbiota plays an important role in the maintenance of host health by providing energy, nutrients, and immunological protection. Applying current molecular methods is necessary to surmount the limitations of classical culturing techniques in order to obtain an accurate description of the microbiota composition.</p> <p>Results</p> <p>Here we report on the comparative assessment of human fecal microbiota from three age-groups: infants, adults and the elderly. We demonstrate that the human intestinal microbiota undergoes maturation from birth to adulthood and is further altered with ageing. The counts of major bacterial groups <it>Clostridium leptum, Clostridium coccoides</it>, <it>Bacteroidetes, Bifidobacterium, Lactobacillus </it>and <it>Escherichia coli </it>were assessed by quantitative PCR (qPCR). By comparing species diversity profiles, we observed age-related changes in the human fecal microbiota. The microbiota of infants was generally characterized by low levels of total bacteria. <it>C. leptum </it>and <it>C. coccoides </it>species were highly represented in the microbiota of infants, while elderly subjects exhibited high levels of <it>E. coli </it>and <it>Bacteroidetes</it>. We observed that the ratio of <it>Firmicutes </it>to <it>Bacteroidetes </it>evolves during different life stages. For infants, adults and elderly individuals we measured ratios of 0.4, 10.9 and 0.6, respectively.</p> <p>Conclusion</p> <p>In this work we have confirmed that qPCR is a powerful technique in studying the diverse and complex fecal microbiota. Our work demonstrates that the fecal microbiota composition evolves throughout life, from early childhood to old age.</p
Embedded-Cluster Calculations in a Numeric Atomic Orbital Density-Functional Theory Framework
We integrate the all-electron electronic structure code FHI-aims into the
general ChemShell package for solid-state embedding (QM/MM) calculations. A
major undertaking in this integration is the implementation of pseudopotential
functionality into FHI-aims to describe cations at the QM/MM boundary through
effective core potentials and therewith prevent spurious overpolarization of
the electronic density. Based on numeric atomic orbital basis sets, FHI-aims
offers particularly efficient access to exact exchange and second order
perturbation theory, rendering the established QM/MM setup an ideal tool for
hybrid and double-hybrid level DFT calculations of solid systems. We illustrate
this capability by calculating the reduction potential of Fe in the
Fe-substituted ZSM-5 zeolitic framework and the reaction energy profile for
(photo-)catalytic water oxidation at TiO2(110).Comment: 12 pages, 4 figure
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