3,251 research outputs found
Neutral interstellar He parameters in front of the heliosphere 1994--2007
Analysis of IBEX measurements of neutral interstellar He flux brought the
inflow velocity vector different from the results of earlier analysis of
observations from GAS/Ulysses. Recapitulation of results on the helium inflow
direction from the past ~40 years suggested that the inflow direction may be
changing with time. We reanalyze the old Ulysses data and reprocess them to
increase the accuracy of the instrument pointing to investigate if the GAS
observations support the hypothesis that the interstellar helium inflow
direction is changing. We employ a similar analysis method as in the analysis
of the IBEX data. We seek a parameter set that minimizes reduced chi-squared,
using the Warsaw Test Particle Model for the interstellar He flux at Ulysses
with a state of the art model of neutral He ionization in the heliosphere, and
precisely reproducing the observation conditions. We also propose a
supplementary method of constraining the parameters based on cross-correlations
of parameters obtained from analysis of carefully selected subsets of data. We
find that the ecliptic longitude and speed of interstellar He are in a very
good agreement with the values reported in the original GAS analysis. We find,
however, that the temperature is markedly higher. The 3-seasons optimum
parameter set is lambda = 255.3, beta = 6, v = 26.0 km/s, T = 7500 K. We find
no evidence that it is varying with time, but the uncertainty range is larger
than originally reported. The originally-derived parameters of interstellar He
from GAS are in good agreement with presently derived, except for the
temperature, which seems to be appreciably higher, in good agreement with
interstellar absorption line results. While the results of the present analysis
are in marginal agreement with the earlier reported results from IBEX, the most
likely values from the two analyses differ for reasons that are still not
understood.Comment: submitted for publication in Astronomy & Astrophysic
Anomalous Spin Dynamics in Doped Quantum Antiferromagnets
Finite-temperature spin dynamics in planar t-J model is studied using the
method based on the Lanczos diagonalization of small systems. Dynamical spin
structure factor at moderate dopings shows the coexistence of free-fermion-like
and spin-fluctuation timescales. At T<J, the low-frequency and static
susceptibility show pronounced T dependence, supporting a scenario, related to
the marginal Fermi-liquid one, for the explanation of neutron-scattering and
NMR-relaxation experiments in cuprates. Calculated NMR relaxation rates
reasonably reproduce experimental ones.Comment: 10 pages + 4 figures, Postscript in uuencoded compressed tar file,
IJS-TP-94/2
Quantum-Critical Behavior in a Two-Layer Antiferromagnet
We analyze quantum Monte Carlo data in the vicinity of the quantum transition
between a Neel state and a quantum paramagnet in a two-layer, square lattice
spin 1/2 Heisenberg antiferromagnet. The real-space correlation function and
the universal amplitude ratio of the structure factor and the dynamic
susceptibility show clear evidence of quantum critical behavior at low
temperatures. The numerical results are in good quantitative agreement with
calculations for the non-linear sigma model. A discrepancy,
reported earlier, between the critical properties of the antiferromagnet and
the sigma model is resolved. We also discuss the values of prefactors of the
dynamic susceptibility and the structure factor in a single layer
antiferromagnet at low .Comment: 11 pages, REVtex file, 5 figures in a uuencoded, gziped file. One
citation added
Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.
Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database.
Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively.
Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors
Interstellar neutral helium in the heliosphere from IBEX observations. III. Mach number of the flow, velocity vector, and temperature from the first six years of measurements
We analyzed observations of interstellar neutral helium (ISN~He) obtained
from the Interstellar Boundary Explorer (IBEX) satellite during its first six
years of operation. We used a refined version of the ISN~He simulation model,
presented in the companion paper by Sokol_et al. 2015, and a sophisticated data
correlation and uncertainty system and parameter fitting method, described in
the companion paper by Swaczyna et al 2015. We analyzed the entire data set
together and the yearly subsets, and found the temperature and velocity vector
of ISN~He in front of the heliosphere. As seen in the previous studies, the
allowable parameters are highly correlated and form a four-dimensional tube in
the parameter space. The inflow longitudes obtained from the yearly data
subsets show a spread of ~6 degree, with the other parameters varying
accordingly along the parameter tube, and the minimum chi-square value is
larger than expected. We found, however, that the Mach number of the ISN~He
flow shows very little scatter and is thus very tightly constrained. It is in
excellent agreement with the original analysis of ISN~He observations from IBEX
and recent reanalyses of observations from Ulysses. We identify a possible
inaccuracy in the Warm Breeze parameters as the likely cause of the scatter in
the ISN~He parameters obtained from the yearly subsets, and we suppose that
another component may exist in the signal, or a process that is not accounted
for in the current physical model of ISN~He in front of the heliosphere. From
our analysis, the inflow velocity vector, temperature, and Mach number of the
flow are equal to lambda_ISNHe = 255.8 +/- 0.5 degree, beta_ISNHe = 5.16 +/-
0.10 degree, T_ISNHe = 7440 +/- 260 K, v_ISNHe = 25.8 +/- 0.4$ km/s, and
M_ISNHe = 5.079 +/- 0.028, with uncertainties strongly correlated along the
parameter tube.Comment: Updated reference
Spin Dependence of Correlations in Two-Dimensional Quantum Heisenberg Antiferromagnets
We present a series expansion study of spin-S square-lattice Heisenberg
antiferromagnets. The numerical data are in excellent agreement with recent
neutron scattering measurements. Our key result is that the correlation length
for S>1/2 strongly deviates from the exact T->0 (renormalized classical, or RC)
scaling prediction for all experimentally and numerically accessible
temperatures. We note basic trends with S of the experimental and series
expansion correlation length data and propose a scaling crossover scenario to
explain them.Comment: 5 pages, REVTeX file. PostScript file for the paper with embedded
figures available via WWW at http://xxx.lanl.gov/ps/cond-mat/9503143
Layer- and bulk roton excitations of 4He in porous media
We examine the energetics of bulk and layer-roton excitations of 4He in
various porous medial such as aerogel, Geltech, or Vycor, in order to find out
what conclusions can be drawn from experiments on the energetics about the
physisorption mechanism. The energy of the layer-roton minimum depends
sensitively on the substrate strength, thus providing a mechanism for a direct
measurement of this quantity. On the other hand, bulk-like roton excitations
are largely independent of the interaction between the medium and the helium
atoms, but the dependence of their energy on the degree of filling reflects the
internal structure of the matrix and can reveal features of 4He at negative
pressures. While bulk-like rotons are very similar to their true bulk
counterparts, the layer modes are not in close relation to two-dimensional
rotons and should be regarded as a third, completely independent kind of
excitation
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