Association between total bilirubin quantiles and type 2 diabetes in MASALA.

Association between total bilirubin quantiles and type 2 diabetes in MASALA.</p

The following supporting information (S1-S5 Tables) file includes supplemental data on subgroup, sensitivity, and exploratory analyses.

The following supporting information (S1-S5 Tables) file includes supplemental data on subgroup, sensitivity, and exploratory analyses.</p

Odds of cardiovascular risk factors in the lowest bilirubin vs. highest bilirubin quartile.

Odds of cardiovascular risk factors in the lowest bilirubin vs. highest bilirubin quartile.</p

Association between total bilirubin tertiles and incident type 2 diabetes by gender.

Association between total bilirubin tertiles and incident type 2 diabetes by gender.</p

Baseline characteristics by bilirubin quartile in males in MASALA, 2010–2018.

Baseline characteristics by bilirubin quartile in males in MASALA, 2010–2018.</p

Association between total bilirubin quartiles and type 2 diabetes among participants without liver dysfunction or CT-based fatty liver.

Association between total bilirubin quartiles and type 2 diabetes among participants without liver dysfunction or CT-based fatty liver.</p

Baseline characteristics by bilirubin quartile in females in MASALA, 2010–2018.

Baseline characteristics by bilirubin quartile in females in MASALA, 2010–2018.</p

Deaths identified by the gold standard definition and Definition 1.1^*.

*<p>Definitions 1.1 given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066116#pone-0066116-t001" target="_blank">Table 1</a>.</p>†<p>‘Zombie’ claims are the claims without ‘death’ issued after the index claim with ‘death’ given as the discharge/disease status.</p>‡<p>Information on death in enrollment file provided by insurers was considered to be the gold standard information.</p>¶<p>‘Zombie’ claims issued up to 1 or 2 months after the index claim.</p>§<p>‘Zombie’ claims issued up to 3 or more months after the index claim.</p

Sensitivity, specificity and PPVs of claims-based definition of death.

<p>Abbreviation: PPV, positive predictive value; 95% CI, 95% confidence interval.</p>*<p>Definitions are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066116#pone-0066116-t001" target="_blank">Table 1</a>.</p

Sensitivity, specificity and PPVs for claims-based Definition 3.3^*.

<p>Abbreviation: PPV, positive predictive value; 95%CI, 95% confidence interval; SSRI, selective serotonin reuptake inhibitor; NSAID, non-steroidal anti-inflammatory drug.</p>*<p>Definition 3.3 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066116#pone-0066116-t001" target="_blank">Table 1</a>.</p>†<p>The gold standard information.</p>‡<p>Definition yielded no false positive cases.</p>¶<p>SSRIs with or without other oral antidepressants.</p>§<p>Oral antidepressants except for SSRIs.</p