Panorama economico e sociale della provincia di Torino

- Lineamenti geografici #21- Cenni storici sullo sviluppo economico #27- Struttura e sviluppo della popolazione #39- Struttura e sviluppo dell'agricoltura #65- Struttura e sviluppo dell'industria #105- Le reti di comunicazione #137- Struttura e sviluppo del commercio #145- Altri aspetti economico sociali della provincia #161- Considerazioni conclusive #18

Le politiche e gli strumenti per l'attuazione del piano regolatore intercomunale di Torino

- Indice #5- Considerazioni generali sulle iniziative da adottare in vista dell'applicazione dei piani intercomunali #6- Politiche e strumenti per l'attuazione del P.R.I. di Torino #1

Centro sociale A.22 n.121-123. Cultura e società italiana in trasformazione. Bibliografia 1960-1974

- Indice #

Programma di studio sullo sviluppo economico di Torino e della sua regione: 1960-61

- Indice #5- Finalità della ricerca #7- Studi settoriali fondamentali #9

Studio per il piano di interventi della Provincia di Torino nel settore scolastico : I° rapporto: situazione scolastica e prime indicazioni operative

- Indice #9- Oggetto e compiti dello studio #19- Gli elementi principali della ricerca #22- Situazione ed andamento del fenomeno scolastico #34- La situazione dell'istruzione prolessionale #61- Le dimensioni dei plessi scolastici e l'organizzazione degli insediamenti #64- Prime indicazioni operative #66- Allegati #7

An Italian survey of opioids misuse: Epidemiological and psychopathological aspects

© 2021 Published by Elsevier Ltd on behalf of International Society for the Study of Emerging Drugs. This is an open access article under the CC BY-NC-ND license, http://creativecommons.org/licenses/by-nc-nd/4.0/Objective Opioid abuse is a worrying reality especially in the US. The increase in the prescription of opioids in Europe poses the risk of a possible increase in the number of abusers also in Italy. The aim of the study is to evaluate the abuse of opioids in the youth population and to evaluate possible correlations with some psychopathological aspects. Methods A survey, conducted from July 2019 to March 2020, about the use of opioids was spread to a group of subjects aged between 18 and 40 years. A socio-demographical investigation and psychometric scales evaluating internet game addiction, gaming online, quality of life and general psychometric features were administrated. Results Nine-hundred and thirteen subjects completed the survey. Seventeen-five subjects (8.21%) have used one opioid at least once in their lifetime. Weak correlations were found between codeine and morphine intensity of use and sleep disturbance, cigarette smoked per day, while codeine correlates with the number of coffees taken per day and somatization. Conclusion Although the data of this survey do not show high percentages of use in Italy (8.21% of the sample have used one of the listed opioids at least once in their lifetime), the correlations founded confirm the literature data already present highlighting the need for constant monitoring of this phenomenon.Peer reviewedFinal Published versio

Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair.

In the last decade, substantial efforts have been made to identify NAD(+) biosynthesis inhibitors, specifically against nicotinamide phosphoribosyltransferase (NAMPT), as preclinical studies indicate their potential efficacy as cancer drugs. However, the clinical activity of NAMPT inhibitors has proven limited, suggesting that alternative NAD(+) production routes exploited by tumors confer resistance. Here, we show the gene encoding nicotinic acid phosphoribosyltransferase (NAPRT), a second NAD(+)-producing enzyme, is amplified and overexpressed in a subset of common types of cancer, including ovarian cancer, where NAPRT expression correlates with a BRCAness gene expression signature. Both NAPRT and NAMPT increased intracellular NAD(+) levels. NAPRT silencing reduced energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells. NAPRT silencing sensitized cells to NAMPT inhibitors both in vitro and in vivo; similar results were obtained with the NAPRT inhibitor 2-hydroxynicotinic acid. Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbated DNA damage in response to chemotherapeutics. In conclusion, NAPRT-dependent NAD(+) biosynthesis contributes to cell metabolism and to the DNA repair process in a subset of tumors. This knowledge could be used to increase the efficacy of NAMPT inhibitors and chemotherapy. Cancer Res; 77(14); 3857-69. ©2017 AACR