Contribution à l'étude des interrelations entre activité physique et aptitude physique et de l'influence de celles-ci sur l'incidence des cardiopathies ischémiques chez des travailleurs d'âge moyen

Doctorat en Sciences de la santé publiqueinfo:eu-repo/semantics/nonPublishe

Failure of nifedipine treatment in primary pulmonary hypertension.

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Tricuspid valve prolapse: Two-dimensional echocardiographic aspects

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Ankle/arm pressure index in asymptomatic middle-age males: an independent predictor of ten-year coronary heart disease mortality

Purpose of the study: to evaluate the predictive power of a reduced ankle/brachial pressure index (ABPI) (≤ .90) in an asymptomatic middle-aged male working population free of coronary heart disease. Materials and Methods: 2023 subjects forty to fifty-five years old were screened at their work place. Standard techniques were used. Blood was drawn in the fasting state. Ankle and brachial blood pressures were measured by Doppler signals and all measures were done by one observer, duly trained in epidemiologic methodology Results: in univariate analysis, an ABPI ≤ .90 was significantly associated with age, total serum cholesterol, body mass index, smoking, and awareness of diabetes. In multi- variate analysis, it was associated with awareness of diabetes, age, Ln triglycerides (P=.073), and smoking (P=.088). Relative risks for reduced versus normal ABPI are 2.77 (P=.010), 4.16 (P=.011) and 4.97 (P=.006) for ten-year all causes, cardiovascular, and coronary mortality, respec tively. In a multiple logistic regression analysis, the following variables were significant independent predictors of coronary mortality: smoking (odds ratio [OR] =4.84), reduced ABPI (OR=3.63), and low density lipoprotein cholesterol (OR for 1 SD=1.69). Reduced ABPI is also an independent predictor of cardiovascular mortality Conclusion: a reduced ABPI is an independent risk factor for coronary and cardio vascular mortality in asymptomatic middle-aged Belgian males. © 1995, Sage Publications. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Prospective, randomized trial of prolonged intracoronary urokinase infusion for chronic total occlusions in native coronary arteries

AbstractObjectives.The purpose of this study was to determine the safety and efficacy of three dosing regimens of intracoronary urokinase for facilitated angioplasty of chronic total native coronary artery occlusions.Background.Percutaneous transluminal coronary angioplasty of chronically occluded (>3 months) native coronary arteries is associated with low initial success secondary to an inability to pass the guide wire beyond the occlusion.Methods.Patients were enrolled if a chronic total occlusion >3 months old could not be crossed with standard angioplasty equipment. Of the 101 patients enrolled, 41 had successful guide wire passage and were excluded from urokinase treatment. The remaining 60 patients were randomized to receive one of three intracoronary dosing regimens of urokinase over 8 h (group A = 0.8 million U; group B = 1.6 million U; group C = 3.2 million U), and angioplasty was again attempted after completion of the urokinase infusion in 58 patients.Results.Coronary angioplasty was successful in 32 patients (53%) (group A 52%, group B 50%, group C 59%, p = 0.86). This study had a 90% power to detect at least a 50% difference between dosing groups at alpha 0.05. Bleeding complications requiring blood transfusion did not differ significantly among the dosing groups (A 0%, B 15%, C 6%, p = 0.14), although major bleeding episodes were less common in group A (p < 0.05). There were no major procedural or in-hospital complications. Angiographic follow-up in 69% of the patients with successful angioplasty revealed target vessel patency in 91% but an angiographic restenosis rate of 59%.Conclusions.A prolonged supraselective intracoronary infusion of urokinase can be safely administered and may facilitate angioplasty of chronic total occlusions. Lower doses of urokinase are equally effective and result in fewer bleeding complications than do higher dosage regimens. Vessel patency is frequently maintained, but restenosis remains a problem

The perception of work stressors is related to reduced parasympathetic activity.

The aim was to examine the perception of work stressors in relation to ambulatory measures of heart rate variability (HRV).Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe