4 research outputs found
MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma
Abstract
Background: Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical and histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) are short, nonâcoding RNA sequences of 19â25 nucleotides in length that are involved in postâtranscriptional protein expression. They have been shown to play important roles in neoplastic and nonâneoplastic processes and have been suggested as diagnostic and prognostic markers.
Methods: This study, using quantitative RTâPCR, investigated miRâ150, miRâ455â3p and miRâ375 expression, in order to identify a possible molecular distinction between AdCC and PAC.
Results: miRNAâ150 and miRNAâ375 expression was significantly decreased in AdCC and PAC compared with salivary gland tissue controls, whilst miRNAâ455â3p showed significantly increased expression in AdCC when compared to PAC, (P < 0.05). miRâ150, miRâ357 and miRâ455â3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) (P > 0.05).
Conclusion: MiRâ455â3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases