A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands

Type 1 diabetes has a substantial genetic component, with consistent evidence for a susceptibility locus in the HLA-DR/DQ region (chromosome 6p) and the insulin gene region (chromosome 11p). Genome scans have identified >18 other genomic regions that may harbor putative type 1 diabetes genes. However, evidence for most regions varies in different data sets. Given the genetic heterogeneity of type 1 diabetes, studies in homogeneous genetically isolated populations may be more successful in mapping susceptibility loci than in complex outbred populations. We describe a genome-wide search in a recently Dutch isolated population. We identified 43 patients that could be traced back to a common ancestor within 15 generations and performed a genome-wide scan using a combined linkage- and association-based approach. In addition to the HLA locus, evidence for type 1 diabetes loci was observed on chromosome 8q24 (marker D8S1128) and on chromosome 17q24 (marker D17S2059). Both the 8q and 17q localization are supported by allele-sharing at adjacent markers in affected individuals. Statistical evidence for a conserved ancestral haplotype was found for chromosome 8q24

Regulation Of The Interurban Coach Services In Brazil

Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Effects of HPV detection in population-based screening programmes for cervical cancer; a Dutch moment.

Contains fulltext : 50243.pdf (publisher's version ) (Closed access)Presently, large randomised studies are investigating the value of incorporating HPV detection in population-based cervical screening programmes to improve the effectiveness of these programmes. None of these studies, however, has assessed the effect of HPV detection on the participation rate of women in these screening programmes. This paper draws attention to the fact that the effectiveness of cervical screening largely depends on the participation rate. A number of possibilities will be addressed on how HPV may affect cervical cancer screening. On the one hand, an option is described that addition of HPV detection, although increasing the sensitivity of screening, may in fact decrease the overall effectiveness of the screening. On the other hand, the possibility is put forward that incorporation of HPV will increase the reduction in mortality because of increased sensitivity and participation to the screening. Our manuscript thereby addresses an important aspect of screening, namely, the societal impact of new diagnostic tests on coverage in population-based screening programmes

Sociabilité des pratiquants sportifs

Analyse de l'enquête 'loisirs 1987-1988' de l'INSEE selon une double optique, sportive et de sociabilité, afin d'étudier les rapports existants entre ces deux dimensions. Sociodémographie et sociabilité, sociodémographie et pratique sportive (différences de pratique selon le sexe, l'âge, les diplômes, la catégorie socioprofessionnelle, les revenus ...). Pratique sportive et sociabilité : les sports les plus associés à la sociabilité générale ne sont pas ceux qui mettent les individus en interaction, mais ceux dans lesquels les individus se confrontent à l'incertitude du milieu de pratique