Molecular mechanisms of experience-dependent maturation in cortical GABAergic inhibition

10.1111/jnc.14103Journal of Neurochemistry1425649-66

Defining a critical period for inhibitory circuits within the somatosensory cortex

10.1038/s41598-017-07400-8Scientific Reports71727

Histone modifications in status epilepticus induced by Kainate

Animal models of epilepsy have allowed the determination of the basic molecular and cellular mechanisms of epileptogenesis. Generalized limbic seizures and subsequent status epilepticus can be induced by either pilocarpine, the muscarinic acetylcholine receptor agonist or kainate, the glutamate receptor agonist. There has been increasing interest that chromatin remodeling might play a critical role in gene regulation even in non-dividing cells such as neurons. One form of chromatin remodeling is histone aminoterminal modification that can generate synergistic or antagonistic affinities for the interactions of transcriptional factors, in turn causing changes in gene activity. Two widely studied histone modification processes are histone acetylation and phosphorylation. While histone hyperacetylation indicates an increase in gene activity, its hypoacetylation marks gene repression. Both states are controlled by a dynamic interplay of histone acetyltransferase (HAT) and histone deacetylase (HDAC). We have found the upregulation of acetylation and phosphorylation of histones, coupled with status epilepticus after kainate administration. c-fos and c-jun mRNA have been sequentially induced in response to kainate, in different hippocampal subpopulations starting from the dentate gyrus and spreading to the cornus ammonis regions well correlated with the spatiotemporal distribution of histone H4 hyperacetylation. Both histone modifications are associated with the c-fos gene promoter after kainate stimulation, while only histone acetylation with the c-jun gene. Pretreatment with curcumin, which has a HAT inhibitory activity specific for CBP/p300, attenuates histone modifications, IEGs expression and also the severity of status epilepticus after kainate treatment. Histone modifications may have a crucial role in the development of epilepsy induced by kainate

Contemporary Network proteomics and its requirements

10.3390/biology3010022Biology3122-3

Analysing extremely small sized ratio datasets

10.1504/IJBRA.2015.069225International Journal of Bioinformatics Research and Applications113268-28

All-optical mapping of barrel cortex circuits based on simultaneous voltage-sensitive dye imaging and channelrhodopsin-mediated photostimulation

10.1117/1.NPh.2.2.021013Neurophotonics2214090SS

Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice

10.1210/en.2015-1848Endocrinology15741660 - 167

Changes in hepatic TRβ protein expression, lipogenic gene expression, and long-chain acylcarnitine levels during chronic hyperthyroidism and triiodothyronine withdrawal in a mouse model

10.1089/thy.2016.0456Thyroid276852 - 86