Quantitative and morphological characteristics of the human corneal endothelium in relation to age, gender, and ethnicity in cataract populations of South Asia

Purpose: To describe the differences of corneal endothelial cell densities, cell size variability and cell hexagonality in cataract populations of south Asia between sexes and ethnic groups. Methods: 1,235 eyes of 1,235 male and female patients 40-75 years of age with senile cataract were examined with non contact specular microscopy with semi-automated analysis technique. The cell data of the study population was analyzed in relation to age, sex, and ethnic groups. Mean arithmetic differences and the coefficient of variation of repeated observations were calculated to estimate precision of the technique utilized. The main outcome measures were corneal endothelial cell density, cell size variability and cell hexagonality. Results: The mean corneal endothelial cell density was 2,720 cells/mm2, mean cell size variability was 37.8% and percent cell hexagonality 40%. We found statistical significant difference between the three ethnic populations in all the corneal endothelial cell measurements (p < 0.0001). Females had a 2.9% greater cell density than males (p = 0.0001). There was no significant difference in mean cell density according to age. Variability of cell size, however, increased with age (p < 0.001). These findings were consistent across the three ethnic groups. Conclusions: In a total sample of 1,235 eyes distributed evenly in three cataract patient populations of south Asia, we found statistically significant differences of corneal endothelial cell densities of cell size variability and cell hexagonality between sexes and ethnic groups

Cell Pattern in Adult Human Corneal Endothelium

A review of the current data on the cell density of normal adult human endothelial cells was carried out in order to establish some common parameters appearing in the different considered populations. From the analysis of cell growth patterns, it is inferred that the cell aging rate is similar for each of the different considered populations. Also, the morphology, the cell distribution and the tendency to hexagonallity are studied. The results are consistent with the hypothesis that this phenomenon is analogous with cell behavior in other structures such as dry foams and grains in polycrystalline materials. Therefore, its driving force may be controlled by the surface tension and the mobility of the boundaries

Outcomes of extracapsular surgery in eye camps of eastern Nepal

BACKGROUND—Extracapsular cataract (ECCE) surgery is becoming increasingly popular in surgical eye camps of developing countries. This study assesses the outcome of 166 eyes at 6 weeks and 14 and 32( )months after ECCE with and without implantation of intraocular lens in refugee camps of eastern Nepal.
METHOD—All patients operated on in seven refugee camps during the 3 years before the assessment were included in the study population. Visual acuity, examination of anterior segment and posterior segments, and grading of capsular opacification using a standardised grading system were performed.
RESULTS—Of 166 eyes examined, of which 49.4% were aphakic, 58% of eyes had very poor functional vision (WHO severe visual impairment—VA <6/60). After refraction and best correction 19% still had very poor vision. The aphakic eyes had both significantly poorer functional and best corrected vision than the pseudophakic eyes. In patients with intact posterior capsule clinically significant posterior capsular opacification was observed in over 10% of eyes at 14( )months and 30% at 32( )months.
CONCLUSION—It was found that ECCE surgery in eye camps in this setting gave unacceptable outcomes because of a high rate of capsular rupture and posterior capsular opacification. Careful consideration should be given to the quality of the surgical set up and available resources and possibilities of postoperative follow up when ECCE is introduced in eye camps.


Prevalence of cataract in the Speedwell Cardiovascular Study: a cross-sectional survey of men aged 65-83

© Royal College of OphthalmologistsAims To ascertain the prevalence of cataract in a representative group of men who have been followed since 1979 for cardiovascular disease. Methods Of 2348 men aged 45-63 recruited in 1979 to the Speedwell Cardiovascular Study, 1420 were alive and willing to take part in further studies in 1997. They were sent a questionnaire about their eye health and invited to an ophthalmological examination at Bristol Eye Hospital. Cataract was graded using the Lens Opacities Classification System III (LOCS III) method. Results Of the 1420 men, 26 died before they could be examined. Out of the remaining 1394 men, 949 presented for examination and full information was available for 936. Some information about eye health was obtainable for 394 men and 51 were not contactable. The prevalence of cataract increased with age and 36 men (3.8%) had had previous cataract surgery in either or both eyes. Of the remaining 903 men with no previous history of cataract surgery, cortical cataract was present in the right eye of 75 men (8.3%), nuclear (opalescence) in 128 (14.2%) and posterior subcapsular in 15 (1.7%). Five men (0.6%) had visual acuity of 6/60 or worse attributable to cataract in the right eye and 232 (25%) had visual acuity in one or both eyes of 6/24 or less at least partially attributable to cataract. There was no association between social class and the presence of cataract. Conclusions The prevalence of cataract in a representative cohort of men followed since 1979 for cardiovascular disease was comparable to that previously reported in the UK and is consistent with studies from around the world. It appears that substantial amounts of visual loss, attributable to cataract, are present in men. Further studies establishing the reasons for this should be undertaken