Left, Right, and the Italian Voter

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68230/2/10.1177_001041407100400202.pd

Green's function for a Schroedinger operator and some related summation formulas

Summation formulas are obtained for products of associated Lagurre polynomials by means of the Green's function K for the Hamiltonian H = -{d^2\over dx^2} + x^2 + Ax^{-2}, A > 0. K is constructed by an application of a Mercer type theorem that arises in connection with integral equations. The new approach introduced in this paper may be useful for the construction of wider classes of generating function.Comment: 14 page

Alkaline rocks in the Kuboos-Bremen Igneous Province, southern Namibia: the Grootpenseiland and Marinkas Kwela Complexes

The early Cambrian Kuboos-Bremen Igneous Province of northwestern South Africa and southern Namibia comprises a series of intrusive bodies that collectively encompass virtually the entire range of alkaline rock types. Two of these bodies, the Grootpenseiland and Marinkas Kwela Complexes lie immediately north of the Orange River and are amongst the few that show this wide lithological range on a local scale

Generating mice with targeted mutations.

Journal ArticleMutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension of this approach to the mouse, through informative, was far less successful relative to what has been achieved with these simpler model organisms. This is because it is not numerically practical in mice to use random mutagenesis to isolate mutations that affect a specified biological process of interest. Nonetheless, biological phenomena such as a sophisticated immune response, cancer, vascular disease or higher-order cognitive function, to mention just a few, must analyzed in organisms that show such phenomena, and for this reason geneticists and other researchers have turned to the mouse. Gene targeting, the means for creating mice with designed mutations in almost any gene, was developed as an alternative to the impractical use of random mutgenesis for pursing genetic analysis in the mouse. Now gene targeting has advanced the genomic manipulations possible in mice to a level that can be matched only in far simple organisms such as bacteria and yeast

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B

Serum protein types were determined in eight recipients and donors in cases of hepatic homotransplantation. A change from recipient type to donor type was observed for factor B, C8, orosomucoid, haptoglobin, transferrin, α1-antitrypsin, C3 and C6, but not for Gm and Inv immunoglobulin markers. The results indicate that all the proteins studied (except immunoglobulins) are produced primarily by the liver in vivo. © 1980

Cotransformation and gene targeting in mouse embryonic stem cells.

We have investigated cotransformation in mammalian cells and its potential for identifying cells that have been modified by gene targeting. Selectable genes on separate DNA fragments were simultaneously introduced into cells by coelectroporation. When the introduced fragments were scored for random integration, 75% of the transformed cells integrated both fragments within the genome of the same cell. When one of the cointroduced fragments was scored for integration at a specific locus by gene targeting, only 4% of the targeted cells cointegrated the second fragment. Apparently, cells that have been modified by gene targeting with one DNA fragment rarely incorporate a second DNA fragment. Despite this limitation, we were able to use the cotransformation protocol to identify targeted cells by screening populations of colonies that had been transformed with a cointroduced selectable gene. When hypoxanthine phosphoribosyltransferase (hprt) targeting DNA was coelectroporated with a selectable neomycin phosphotransferase (neo) gene into embryonic stem (ES) cells, hprt-targeted colonies were isolated from the population of neo transformants at a frequency of 1 per 70 G418-resistant colonies. In parallel experiments with the same targeting construct, hprt-targeted cells were found at a frequency of 1 per 5,500 nonselected colonies. Thus, an 80-fold enrichment for targeted cells was observed within the population of colonies transformed with the cointroduced DNA compared with the population of nonselected colonies. This enrichment for targeted cells after cotransformation should be useful in the isolation of colonies that contain targeted but nonselectable gene alterations

An overview of adakite, tonalite-trondhjemite-granodiorite (TTG), and sanukitoid; relationships and some implications for crustal evolution.

Abstract Examination of an extensive adakite geochemical database identifies two distinct compositional groups. One consists of high-SiO 2 adakites (HSA) which is considered to represent subducted basaltic slab-melts that have reacted with peridotite during ascent through mantle wedge. The second group consists of low-SiO 2 adakites (LSA) which we interpret to have formed by melting of a peridotitic mantle wedge whose composition has been modified by reaction with felsic slab-melts. The chemical composition of less differentiated (primitive) Archaean tonalite-trondhjemite-granodiorite (TTG) magmas evolved from 4.0 to 2.5 Ga. Mg# (molecular Mg/(Mg+Fe 2+ ), Ni, and Cr contents increased over this period of time and we interpret these changes in terms of changes in the degree to which the TTG magmas interacted with mantle peridotite. Over the same period, concentrations of (CaO+Na 2 O) and Sr also increased, as the amount of plagioclase, residual from basalt melting, decreased in response to increased pressures at the site of slab-melting. In the Early Archaean, it appears that these interactions were very rare or absent thus leading to the conclusion that subduction was typically flat and lacked the development of a mantle wedge. In contrast, the relatively lower heat production by~2.5 Ga meant that slab-melting occurred at greater depth, where plagioclase was no longer stable, and where the development of a thick mantle wedge ensured interaction between the slab-melts and mantle peridotite. Close compositional similarities between HSA and Late Archaean TTG (Tb~3.0 Ga) strongly suggest a petrogenetic analogy. However, an analogy between the older Archaean TTG and HSA is not complete because evidence for mantle wedge interaction is missing in most Early Archaean TTGs. Late Archaean sanukitoids and the compositionally similar Closepet-type granites have compositions significantly different from TTG of all ages. However, they show some affinity with LSA which could be considered as their possible analogue. These magmas are all thought to result from melting of a mantle peridotite whose composition has been modified by reaction with slab-melts. We propose that all these magmas are directly linked to slab-melting. Archaean TTG and HSA represent slab-melts that have interacted with peridotite to varying extent, whereas sanukitoids, Closepet-type granites, and LSA correspond to melts of peridotite previously metasomatised by slab-melt. The changes observed from Early Archaean TTG to Late Archaean TTG and to sanukitoids reflect change in both the nature and efficiency of interaction between slab-melt and mantle wedge peridotite. Comparisons between all of these rocks suggest that ancient styles of subduction that have operated since at least~3.3 Ga persist in a limited way today. The secular changes in the degree and style of these interactions is a direct consequence of the cooling of Earth that modified the thermal and dynamic parameters at the subducted slab-mantle wedge interface.