Interactions Between Cultural Attitudes, Cultural Instruction, and Second Language Use by International Students at the University Level

While participating in study abroad programs, language instructors and learners alike hope that learners will have many opportunities for communicative intercultural engagement in the second language (L2). Such interactions are desirable because correlations exist between the quantity and quality of L2 interactions that learners have and the ultimate language gains that they attain while studying in a host country (e.g., Baker-Smemoe, et al., 2012; Dewey, et al., 2013; Isabelli-Garcia, 2006). In order to optimize L2 development, this study investigates learners\u27 out-of-class L2 use, cultural attitudes, and social motivations, in addition to analyzing how these factors may be impacted by different types of cultural instruction. The data for this study are drawn from two upper-intermediate, first-year classes of English as a Second Language (ESL) at a university in the US, targeting the following: (1) free-writing exercises involving cultural knowledge and experiences, and (2) a pre- and post-intervention survey of cultural attitudes and intercultural L2 use. The intervention provided explicit cultural instruction in one class and implicit cultural instruction in the other. Quantitative and qualitative analyses focus on the ways in which explicit and implicit cultural instruction impact learners\u27 attitudes, which may relate to the ways in which they interact in the L2, integrate into the host community, and use the L2 meaningfully for intercultural interactions outside of class. Results offer insights into the baseline cultural attitudes and social motivations of ESL learners who have recently arrived for extended study abroad experiences in the US, in addition to providing information regarding learners\u27 patterns of L2 usage and their perspectives on intercultural communication. Statistical analyses demonstrate that while attitudes and motivations did have positive increases throughout the course of one semester, varying pedagogical interventions involving explicit or implicit methods of cultural instruction did not appear to have a significant effect. This may have implications for course design as instructors consider how to best provide cultural instruction in the second language classroom

Guadecitabine, in combination with Cyclophosphamide, promotes anti- cancer immunity in BALB/c mice bearing 4T1 mouse mammary carcinoma

Background: The extremely high mortality rate of patients diagnosed with triple negative breast cancer makes it one of the deadliest forms of cancer. Due to the heterogenous nature of tumors, complete clearance is not achieved and clonal selection occurs resulting in tumor cells evading the immune system. I aim to design a therapeutic intervention that is able to elicit an effective immune response against the tumor and instill immunological memory to eradicate primary and metastatic lesions. I hypothesize that the combination of Guad and Cyp will synergize and promote anticancer immunity via increased expression of neo-tumor antigens and depletion of MDSCs and T-regs. Methods: Guadecitabine (Guad), is a second-generation DNA methyltransferase inhibitor (DMNTi) that has been reported to increase antigenicity and deplete myeloid-derived suppressor cells (MDSC’s). Cyclophosphamide (Cyp) is a chemotherapy that has been shown to deplete regulatory T-cells (T-regs). Both MDSD’s and T-regs suppress antitumor immunity. BALB/c mice were challenged with 4T1 tumor cells subcutaneously in the mammary fat pad region. 4T1-bearing mice were administered low-dose Guad and Cyp for ten consecutive days. Tumor growth curves, tumor-infiltrating lymphocytes (TILs) were measured and MDSC’s and T- regs levels were assessed by flow cytometry. Results: Results from this experiment showed significant synergy between Guad and Cyp with both drugs reducing the tumor size over monotherapy. Conclusions: Further analysis of the data along with future experiments will elucidate if this synergy is driven by the depletion of MDSC’s and T-regs alone or the increase in tumor antigenicity inducing increased numbers of TILs.https://scholarscompass.vcu.edu/gradposters/1078/thumbnail.jp

“Eat Yourself Full, Leave Your Plate Empty”: Or Why Student and Faculty Appetite for Data Is Like an Offensive Lineman at a Buffet

From an old postcard of Millers’s Smorgasbord (on the Lincoln Highway east of Lancaster, Pennsylvania) we see the sign that stands over the scrumptious buffet welcoming all patrons at the restaurant: “Eat Yourself Full, Leave Your Plate Empty.” The notion is simple, take what you can eat but do not waste food. But in many ways, the whole premise of a buffet is the ability to try, sample, nibble, and experiment with foods that you might not order otherwise order. And we all pay the same, even if we are a college football offensive lineman with a legendary appetite. It is this conundrum that leads us into problems between libraries and the database vendors. Librarians scramble to keep the balance between the students’ needs of getting and analyzing data with the vendors’ needs to keep the systems working and not to be overburdened with royalty payments to the publishers. Increasingly, we see faculty and students wanting to download more data, but vendors too quick to install restrictions out of intellectual property concerns. In this “Eat Yourself Full” database environment, our students and faculty want to download more and more to analyze and interpret on their own. The presenters will explore the issues of downloading caps and other obstacles at the business libraries of three large U.S. public universities (Illinois, Michigan, and UCLA). Among the topics discussed will be the topics that drive this research, the types of resources they wish to use, the impact of the limits imposed on the students and faculty, and the workarounds that connected the user to the data that they needed

Special Education in Juvenile Residential Facilities: Can Animals Help?

Children with emotional/behavioral disorders (EBD) are arguably one of the highest at-risk groups for dropping out before graduating high school. They are the group of students with disabilities who are most likely to be educated in residential facilities. Residential facilities such as Green Chimneys have incorporated animals into the treatment milieu with success. Animals have been used in various settings to improve the quality of life as well as the emotional and physical needs of people served by these facilities. This article describes the requirements for using animals in residential treatment, the limitations of such programs, and the research findings for the use of animal-assisted therapy or activities (AAT/AAA). Using Gardner’s (1999) iteration of his theory of multiple intelligence, the authors proposed an understanding of how these treatments might be improve the intelligence of a child with EBD. Requirements for effective treatment of special needs children were discussed

What Works in Conservation 2021

This book provides an assessment of the effectiveness of 2526 conservation interventions based on summarized scientific evidence. The 2021 edition contains substantial new material on bat conservation, terrestrial mammal conservation and marine and freshwater mammals, thus completing the evidence for all mammal species categories. Other chapters cover practical global conservation of primates, amphibians, bats, birds, forests, peatlands, subtidal benthic invertebrates, shrublands and heathlands, as well as the conservation of European farmland biodiversity and some aspects of enhancing natural pest control, enhancing soil fertility, management of captive animals and control of freshwater invasive species. It contains key results from the summarized evidence for each conservation intervention and an assessment of the effectiveness of each by international expert panels. The accompanying website www.conservationevidence.com describes each of the studies individually, and provides full references. This is the sixth author-approved edition of What Works in Conservation, which is revised on an annual basis

Mixed-Grass Prairie Canopy Structure and Spectral Reflectance Vary with Topographic Position

Managers of the nearly 0.5 million ha of public lands in North and South Dakota, USA rely heavily on manual measurements of canopy height in autumn to ensure conservation of grassland structure for wildlife and forage for livestock. However, more comprehensive assessment of vegetation structure could be achieved for mixed-grass prairie by integrating field survey, topographic position (summit, mid and toeslope) and spectral reflectance data. Thus, we examined the variation of mixed-grass prairie structural attributes (canopy leaf area, standing crop mass, canopy height, nitrogen, and water content) and spectral vegetation indices (VIs) with variation in topographic position at the Grand River National Grassland (GRNG), South Dakota. We conducted the study on a 36,000-ha herbaceous area within the GRNG, where randomly selected plots (1 km2 in size) were geolocated and included summit, mid and toeslope positions. We tested for effects of topographic position on measured vegetation attributes and VIs calculated from Landsat TM and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data collected in July 2010. Leaf area, standing crop mass, canopy height, nitrogen, and water content were lower at summits than at toeslopes. The simple ratio of Landsat Band 7/Band 1 (SR71) was the VI most highly correlated with canopy standing crop and height at plot and landscape scales. Results suggest field and remote sensing-based grassland assessment techniques could more comprehensively target low structure areas at minimal expense by layering modeled imagery over a landscape stratified into topographic position groups

Mixed-Grass Prairie Canopy Structure and Spectral Reflectance Vary with Topographic Position

Managers of the nearly 0.5 million ha of public lands in North and South Dakota, USA rely heavily on manual measurements of canopy height in autumn to ensure conservation of grassland structure for wildlife and forage for livestock. However, more comprehensive assessment of vegetation structure could be achieved for mixed-grass prairie by integrating field survey, topographic position (summit, mid and toeslope) and spectral reflectance data. Thus, we examined the variation of mixed-grass prairie structural attributes (canopy leaf area, standing crop mass, canopy height, nitrogen, and water content) and spectral vegetation indices (VIs) with variation in topographic position at the Grand River National Grassland (GRNG), South Dakota. We conducted the study on a 36,000-ha herbaceous area within the GRNG, where randomly selected plots (1 km2 in size) were geolocated and included summit, mid and toeslope positions. We tested for effects of topographic position on measured vegetation attributes and VIs calculated from Landsat TM and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data collected in July 2010. Leaf area, standing crop mass, canopy height, nitrogen, and water content were lower at summits than at toeslopes. The simple ratio of Landsat Band 7/Band 1 (SR71) was the VI most highly correlated with canopy standing crop and height at plot and landscape scales. Results suggest field and remote sensing-based grassland assessment techniques could more comprehensively target low structure areas at minimal expense by layering modeled imagery over a landscape stratified into topographic position groups

Mild Traumatic Brain Injury and Treatment Response in Prolonged Exposure for PTSD

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98185/1/jts21813.pd

Role of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion

Viral fusion proteins are intriguing molecular machines that undergo drastic conformational changes to facilitate virus-cell membrane fusion. During fusion a hydrophobic region of the protein, termed the fusion peptide (FP), is inserted into the target host cell membrane, with subsequent conformational changes culminating in membrane merger. Class I fusion proteins contain FPs between 20 and 30 amino acids in length that are highly conserved within viral families but not between. To examine the sequence dependence of the Hendra virus (HeV) fusion (F) protein FP, the first eight amino acids were mutated first as double, then single, alanine mutants. Mutation of highly conserved glycine residues resulted in inefficient F protein expression and processing, whereas substitution of valine residues resulted in hypofusogenic F proteins despite wild-type surface expression levels. Synthetic peptides corresponding to a portion of the HeV F FP were shown to adopt an α-helical secondary structure in dodecylphosphocholine micelles and small unilamellar vesicles using circular dichroism spectroscopy. Interestingly, peptides containing point mutations that promote lower levels of cell-cell fusion within the context of the whole F protein were less α-helical and induced less membrane disorder in model membranes. These data represent the first extensive structure-function relationship of any paramyxovirus FP and demonstrate that the HeV F FP and potentially other paramyxovirus FPs likely require an α-helical structure for efficient membrane disordering and fusion