Sounding Modern, Sounding Moral: Censorship and Hollywood’s Transition to Sound

This thesis examines the relationship between Hollywood’s transition to synchronized sound and the rise of the industry’s self-censorship practices, processes which were precisely commensurate during the late 1920s and early 1930s. Through nuanced historiographical discussion, this thesis explores how the transition to sound interfaced with other mechanisms at work in the Hollywood industry of the late 1920s—namely, regulatory discourses and practices. Both of these processes represent crucial shifts in the technologies, practices, and politics of Hollywood filmmaking. This thesis proposes that this coalescence produced compelling negotiations visible in the films of that era. Synchronized sound film is defined as part of a broader web of emergent sound media which, as Steve Wurtzler (2007) argues, interfaced with pre-existing concerns surrounding technologically mediated modernity and its effects on traditional morality. The study is illustrated by discussion of two part-talkie films of the flapper cycle, Our Dancing Daughters (1928) and Our Modern Maidens (1929) both of which negotiate a new technological terrain and indicate Hollywood’s ongoing negotiations with contemporaneous film-morality debates

Effects of exercise, cognitive, and dual-task interventions on cognition in type 2 diabetes mellitus: A systematic review and meta-analysis

Introduction: Previous evidence has shown significant effects of exercise, cognitive and dual-task training for improving cognition in healthy cohorts. The effects of these types of interventions in type 2 diabetes mellitus is unclear. The aim of this research was to systematically review evidence, and estimate the effect, of exercise, cognitive, and dual-task interventions on cognition in type 2 diabetes mellitus. Method: Electronic databases including PubMed, EMBASE, CINAHL, PsycINFO, SPORTDiscus, and MEDLINE were searched for ongoing and completed interventional trials investigating the effect of either an exercise, cognitive or dual-task intervention on cognition in type 2 diabetes mellitus. Results: Nine trials met the inclusion criteria – one dual-task, two cognitive, and six exercise. Meta-analyses of exercise trials showed no significant effects of exercise on measures of executive function (Stroop task, SMD= -0.31, 95% CI -0.71–0.09, P=0.13, trail making test part A SMD= 0.28, 95% CI -0.20–0.77 P=0.25, trail making test part B SMD= -0.15, 95% CI -0.64–0.34 P=0.54, digit symbol SMD= 0.09, 95% CI -0.39–0.57 P=0.72), and memory (immediate memory SMD= 0.20, 95% CI -0.28–0.69, P=0.41 and delayed memory SMD= -0.06, 95% CI -0.55–0.42, P=0.80). A meta-analysis could not be conducted using cognitive or dual-task data, but individual trials did report a favourable effect of interventions on cognition. Risk of bias was considered moderate to high for the majority of included trials. Conclusions: Meta-analyses of exercise trials identified a small effect size (0.31), which whilst not significant warrants further investigation. Larger and more robust trials are needed that report evidence using appropriate reporting guidelines (e.g. CONSORT) to increase confidence in the validity of results. Trial Registration: Protocol was registered (CRD42017058526) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO)

Birthing While Black: The Maternal Health Experiences in Kansas

The state of maternal health and infant mortality in the United States is far worse than 33 developed countries (CDCP NCHS, 2018). Black mothers and infants die at twice the rate in comparison to mothers and infants of other races (CDC, 2020). Infant mortality is the death of a child before the age of one. The Sisters and Brothers for Healthy Infants Initiative focuses on education, community engagement, elevating the voices of Black mothers and fathers, and a community birthday party to celebrate Black infants first birthday. This signature event is known as Celebrate Day 366, a day to share information Black infant mortality, co-parenting, and fatherhood, conduct a community conversation on birth equity, and celebrate Black babies first birthday. This paper reflects the results from a panel discussion of community members and stakeholders in Kansas sharing their experiences with maternal and infant mortality. The Health Equity Framework four main components (systems of power, relationships and networks, individual factors, physiological pathways, that are integral to the inequities in maternal health and infant mortality was used to guide our research analysis (Peterson, et. al 2020). As a part of the qualitative content analysis, five themes emerged: 1) stress during pregnancy; 2) advocacy; 3) innovation of technology not equating to health equity; 4) realization of inferior care; and 5) racism and stereotypes. The themes reflected similar lived experiences amongst Black mothers, fathers, and physicians surrounding maternal health and infant mortality inequities. The results of the CD366 panel discussion highlight the importance of exploring how, if at all, Black mothers and fathers, are benefiting from the birthing experience

Enhancing activity, nutrition and mental health in overweight adolescents. Stage 1 – Formative research

The aim of the project was to refine, implement and evaluate a multi-disciplinary family-centred community-based intervention intended to influence the physical activity, nutrition and psychosocial behaviours of overweight adolescents in Western Australia

Do overweight adolescents adhere to dietary intervention messages? Twelve-month detailed dietary outcomes from curtin university’s activity, food and attitudes program

Dietary components of adolescent obesity interventions are rarely evaluated with comprehensive reporting of dietary change. The objective was to assess dietary change in overweight adolescents, including adherence to dietary intervention. The dietary intervention was part of a multi-component intervention (CAFAP) targeting the physical activity, sedentary and healthy eating behaviors of overweight adolescents (n = 69). CAFAP was a staggered entry, within-subject, waitlist controlled clinical trial with 12 months of follow up. Diet was assessed using three-day food records and a brief eating behavior questionnaire. Changes in dietary outcomes were assessed using linear mixed models, adjusted for underreporting. Food record data suggested reduced adherence to dietary intervention messages over time following the intervention, despite conflicting information from the brief eating behavior questionnaire. During the intervention, energy intake was stable but favorable nutrient changes occurred. During the 12 month maintenance period; self-reported eating behaviors improved, energy intake remained stable but dietary fat and saturated fat intake gradually returned to baseline levels. Discrepancies between outcomes from brief dietary assessment methods and three-day food records show differences between perceived and actual intake, highlighting the need for detailed dietary reporting. Further, adherence to dietary intervention principles reduces over time, indicating a need for better maintenance support

Investigating the effect of exercise, cognitive and dual-task interventions upon cognitive function in type 2 diabetes mellitus: a systematic review and meta-analysis

Objectives/purpose: Whilst exercise, cognitive, and dual-task interventions have been shown to improve cognitive function within a healthy aging population, it remains unclear as to what effect such interventions may have in a type 2 diabetes mellitus (T2DM) population. Design: Systematic review/meta-analyses. Methods: Databases (PubMed, EMBASE, CINAHL, Web of Science, ClinicalTrial.gov, Cochrane register of controlled trials, Prospero, HTA, and DARE) of published, unpublished, and ongoing studies were searched for randomised controlled trials investigating the effect of exercise, cognitive and dual-task interventions upon cognitive function in T2DM. Results: This review identified three studies investigating the effects of an exercise intervention and one study investigating the effect of a cognitive intervention upon cognitive function in T2DM. Meta-analyses indicated a significant effect of exercise for improving global cognitive function (minimental state examination P<0.05) and inhibitory control (Stroop task P<0.05) but not working memory (digit symbol P=0.35). Calculated effect sizes of outcome measures in the cognitive study indicated a beneficial effect of cognitive training upon cognitive function in T2DM. The risk of bias assessment in this review was hindered predominantly by poor reporting practices of included studies. Due to incomplete reporting of 12 methodological procedures, two studies were judged to have a high risk of overall bias whilst the remaining two were judged as having a moderate overall risk of bias. Conclusions: The findings of the present systematic review and meta-analyses provide evidence for exercise and cognitive interventions improving cognitive function in T2DM. The poor reporting practices of included studies means that future research in this area should identify relevant reporting guidelines (e.g. CONSORT) to reduce the risk of bias and facilitate transparent reporting

Matrix Metalloproteinase 13 From Satellite Cells is Required for Efficient Muscle Growth and Regeneration

Background/Aims: Cell migration and extracellular matrix remodeling underlie normal mammalian development and growth as well as pathologic tumor invasion. Skeletal muscle is no exception, where satellite cell migration replenishes nuclear content in damaged tissue and extracellular matrix reforms during regeneration. A key set of enzymes that regulate these processes are matrix metalloproteinases (MMP)s. The collagenase MMP-13 is transiently upregulated during muscle regeneration, but its contribution to damage resolution is unknown. The purpose of this work was to examine the importance of MMP-13 in muscle regeneration and growth in vivo and to delineate a satellite cell specific role for this collagenase. Methods: Mice with total and satellite cell specific Mmp13 deletion were utilized to determine the importance of MMP-13 for postnatal growth, regeneration after acute injury, and in chronic injury from a genetic cross with dystrophic (mdx) mice. We also evaluated insulin-like growth factor 1 (IGF-1) mediated hypertrophy in the presence and absence of MMP-13. We employed live-cell imaging and 3D migration measurements on primary myoblasts obtained from these animals. Outcome measures included muscle morphology and function. Results: Under basal conditions, Mmp13-/- mice did not exhibit histological or functional deficits in muscle. However, following acute injury, regeneration was impaired at 11 and 14 days post injury. Muscle hypertrophy caused by increased IGF-1 was blunted with minimal satellite cell incorporation in the absence of MMP-13. Mmp13-/- primary myoblasts displayed reduced migratory capacity in 2D and 3D, while maintaining normal proliferation and differentiation. Satellite cell specific deletion of MMP-13 recapitulated the effects of global MMP-13 ablation on muscle regeneration, growth and myoblast movement. Conclusion: These results show that satellite cells provide an essential autocrine source of MMP-13, which not only regulates their migration, but also supports postnatal growth and resolution of acute damage. © 2020 The Author(s). Published by Cell Physiol Biochem Press GmbH&Co. K

A comparison of plot-based satellite and Earth system model estimates of tropical forest net primary production

Net primary production (NPP) by plants represents the largest annual flux of carbon dioxide (CO2) from the atmosphere to the terrestrial biosphere, playing a critical role in the global carbon (C) cycle and the Earth’s climate. Rates of NPP in tropical forests are thought to be among the highest on Earth, but debates about the magnitude, patterns, and controls of NPP in the tropics highlight uncertainty in our understanding of how tropical forests may respond to environmental change. Here, we compared tropical NPP estimates generated using three common approaches: (1) field-based methods scaled from plot-level measurements of plant biomass, (2) radiation-based methods that model NPP from satellite-derived radiation absorption by plants, (3) and biogeochemical model-based methods. For undisturbed tropical forests as a whole, the three methods produced similar NPP estimates (i.e. about 10 Pg C yr1). However, the three different approaches produced vastly different patterns of NPP both in space and through time, suggesting that our understanding of tropical NPP is poor and that our ability to predict the response of NPP in the tropics to environmental change is limited. To address this shortcoming, we suggest the development of an expanded, high-density, permanent network of sites where NPP is continuously evaluated using multiple approaches. Well-designed NPP megatransects that include a high-density plot network would significantly increase the accuracy and certainty in the observed rates and patterns of tropical NPP and improve the reliability of Earth system models used to predict NPP–carbon cycle–climate interactions into the futur