A combined HST/CFH12k/XMM survey of X-ray luminous clusters of galaxies at z~0.2

We describe a project to study a sample of X-ray luminous clusters of galaxies at redshift z~0.2 at several scales (with HST/WFPC2 and CFHT/CFH12k) and wavebands (optical and X-ray). The main aims of the project are (i) to determine the mass profiles of the clusters on scales ranging from ~10 kpc/h to >1.5 Mpc/h using weak and strong lensing, thereby testing theoretical predictions of a ``universal mass profile'', and (ii) to calibrate the M_tot - T_X relation in view of future application in the study of the evolution of the cluster mass function at higher redshift.Comment: 4 pages, 2 figures, Proceedings of the XXth Moriond Astrophysics Meeting ``Cosmological Physics with Gravitational Lensing'', J.-P. Kneib, Y. Mellier, M. Moniez and J. Tran Thanh Van eds., 200

The circadian fluctuation of melatonin in \u3cem\u3eStenostomum virginianum\u3cem\u3e

Much is known about melatonin and its role in the circadian regulation of vertebrate organisms. However, melatonin has not been studied extensively in more primitive bilaterians. The aim of this study was to analyze the relationship between melatonin and the circadian rhythm in the organism Stenostomum virginianum. Melatonin assay methods from previous research in the field were optimized for smaller tissue sampling of microscopic metazoans. The optimized assay methodology was then used to identify melatonin in Stenostomum virginianum using high performance liquid chromatography (HPLC). Identification of photoreceptors was used to correlate the presence of melatonin to the circadian rhythm. PAX-6 was chosen for study because it is considered the master eye regulatory gene. Immunohistochemistry and confocal microscopy confirmed the presence of PAX-6 in the anterior region of S. virginianum. The next step in this project is the examination of melatonin concentration at various time points and the comparison of the fluctuation pattern to the S. virginianum sleep and reproduction cycles. Following this comparison, the next logical step is the analysis of melatonin biosynthetic enzymes. This project builds on the work of Dan Stanton and Julian P. Smith, PhD

Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial)

© 2017 The Author(s). Background: Peripheral arterial disease (PAD) has a population prevalence of 4.6% with intermittent claudication (IC) presenting as one of the earliest and most common symptoms. PAD has detrimental effects on patients' walking ability in terms of maximum walking distance (MWD) and pain-free walking distance (PFWD). Research has suggested extracorporeal shockwave therapy (ESWT) may induce angiogenesis in treated tissue; therefore, our objective is to assess the tolerability and efficacy of ESWT as a novel treatment of intermittent claudication. Methods/design: Patients with unilateral claudication will be randomised to receive either ESWT (PiezoWave 2 shockwave system) or sham treatment to the calf muscle bulk three times per week for 3 weeks. All patients are blinded to treatment group, and all assessments will be performed by a masked assessor. Treatment tolerability using a visual analogue scale, ankle-brachial pressure index, MWD, PFWD and safety will all be formally assessed as outcome measures at baseline and at 4, 8 and 12 weeks follow-up. Discussion: This trial will be the first of its kind in terms of methodology in relation to ESWT for intermittent claudication. A double-masked randomised controlled trial will provide useful information about the potential for the use of ESWT as a non-invasive treatment option and the need for further robust research. Trial registration: ClinicalTrials.gov, NCT02652078. Registered on 17 October 2014

Adapting water management to climate change in the Murray–Darling Basin, Australia

Climate change is threatening water security in water-scarce regions across the world, challenging water management policy in terms of how best to adapt. Transformative new approaches have been proposed, but management policies remain largely the same in many instances, and there are claims that good current management practice is well adapted. This paper takes the case of the Murray–Darling Basin, Australia, where management policies are highly sophisticated and have been through a recent transformation in order to critically review how well adapted the basin’s management is to climate change. This paper synthesizes published data, recent literature, and water plans in order to evaluate the outcomes of water management policy. It identifies several limitations and inequities that could emerge in the context of climate change and, through synthesis of the broader climate adaptation literature, proposes solutions that can be implemented when basin management is formally reviewed in 2026

The Abundances Of Neutron-Capture Species In The Very Metal-Poor Globular Cluster M15: A Uniform Analysis Of Red Giant Branch And Red Horizontal Branch Stars

The globular cluster M15 is unique in its display of star-to-star variations in the neutron-capture elements. Comprehensive abundance surveys have been previously conducted for handfuls of M15 red giant branch (RGB) and red horizontal branch (RHB) stars. No attempt has been made to perform a single, self-consistent analysis of these stars, which exhibit a wide range in atmospheric parameters. In the current effort, a new comparative abundance derivation is presented for three RGB and six RHB members of the cluster. The analysis employs an updated version of the line transfer code MOOG, which now appropriately treats coherent, isotropic scattering. The apparent discrepancy in the previously reported values for the metallicity of M15 RGB and RHB stars is addressed and a resolute disparity of Delta(RHB-RGB) approximate to 0.1 dex in the iron abundance was found. The anti-correlative behavior of the light neutron-capture elements (Sr, Y, Zr) is clearly demonstrated with both Ba and Eu, standard markers of the s- and r-process, respectively. No conclusive detection of Pb was made in the RGB targets. Consequently for the M15 cluster, this suggests that the main component of the s-process has made a negligible contribution to those elements normally dominated by this process in solar system material. Additionally for the M15 sample, a large Eu abundance spread is confirmed, which is comparable to that of the halo field at the same metallicity. These abundance results are considered in the discussion of the chemical inhomogeneity and nucleosynthetic history of M15.National Science Foundation AST 07-07447, AST 09-08978Astronom

Testing models of inflation with CMB non-gaussianity

Two different predictions for the primordial curvature fluctuation bispectrum are compared through their effects on the Cosmic Microwave Background temperature fluctuations. The first has a local form described by a single parameter f_{NL}. The second is based on a prediction from the warm inflationary scenario, with a different dependence on wavenumber and a parameter f_{WI}. New expressions are obtained for the angular bispectra of the temperature fluctuations and for the estimators used to determine $f_{NL}$ and f_{WI}. The standard deviation of the estimators in an ideal experiment is roughly 5 times larger for f_{WI} than for f_{NL}. Using 3 year WMAP data gives limits -375<f_{WI}<36.8, but there is a possibility of detecting a signal for f_{WI} from the Planck satellite.Comment: 13 pages, 5 figures in ReVTe

Empathic and Self-Regulatory Processes Governing Doping Behavior

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- (n = 195) and individual- (n = 169) sport athletes and hardcore- (n = 125) and corporate- (n = 121) gym exercisers representing both genders (nmale = 371; nfemale = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts

Responsibility modelling for civil emergency planning

This paper presents a new approach to analysing and understanding civil emergency planning based on the notion of responsibility modelling combined with HAZOPS-style analysis of information requirements. Our goal is to represent complex contingency plans so that they can be more readily understood, so that inconsistencies can be highlighted and vulnerabilities discovered. In this paper, we outline the framework for contingency planning in the United Kingdom and introduce the notion of responsibility models as a means of representing the key features of contingency plans. Using a case study of a flooding emergency, we illustrate our approach to responsibility modelling and suggest how it adds value to current textual contingency plans