A Study to Determine the Effects of Lengthy Space Exposure on Tomato Seeds and Plants

Through the analysis of the data collected from the identical planting techniques of the flight seeds verses the control seeds, the following hypothesis was considered: H1-the tomato seeds of the SEEDS program will produce genetically altered mutant plants

Facility Administrator Perceptions of the External Environmental Constituencies Shaping Urban Advanced Technology Centers

The purpose of this study was to develop a list of the most relevant external environmental constituencies and responses to those elements that should be used by facility administrators of urban advanced technology centers. A three-round Delphi research method was conducted to garner the perceptions of the panel participants. The President\u27s Advisory Council and the Board of Directors of the National Coalition of Advanced Technology Centers were asked to nominate facility administrators of urban advanced technology centers to serve as expert panel participants. Of the 17 facility administrators nominated, nine agreed to participate and completed all three rounds of the investigation. The first research question asked facility administrators to define those external environmental constituencies of urban advanced technology centers that are relevant to goal setting, goal achievement, effectiveness, and survival. From the inputs of the panelists, 14 relevant external environmental constituencies were derived. The results identified a broad array of external influences including other educational organizations, area politicians, cultural values, demographics, and economic development organizations. The second research question was to determine the relative importance of the 14 identified external environmental constituencies. Median scores assessing the relevance of the external environmental constituencies were obtained from the final two rounds of the Delphi study. With total consensus, area business and advanced technology center cultural values were perceived to be the most relevant external environmental constituencies. Economic and market forces, information technologies, and current workers were identified by the panelists to be relevant to urban advanced technology centers. Accrediting agencies and taxpayers were perceived by the panelists to have only limited relevance to goal setting, goal achievement, effectiveness, and survival of urban advanced technology centers. To answer research question three, how should facility administrators of urban advanced technology centers respond to the 14 identified relevant external environmental constituencies, the researcher reviewed various external management strategies for possible use. The external management strategies suggested were planning and forecasting, boundary spanning, adjusting internal operations, establishing favorable linkages and altering the external environment. The findings from this study provide facility administrators of urban advanced technology centers with a listing of relevant external environmental constituencies as perceived by other practicing facility administrators. Use of these findings could prove beneficial to urban advanced technology center facility administrators attempting to respond to the multitude of demands from external environmental constituencies

Retrieving Decadal Climate Change from Satellite Radiance Observations-A 100-year CO2 Doubling OSSE Demonstration.

Preparing for climate change depends on the observation and prediction of decadal trends of the environmental variables, which have a direct impact on the sustainability of resources affecting the quality of life on our planet. The NASA Climate Absolute Radiance and Refractivity Observatory (CLARREO) mission is proposed to provide climate quality benchmark spectral radiance observations for the purpose of determining the decadal trends of climate variables, and validating and improving the long-range climate model forecasts needed to prepare for the changing climate of the Earth. The CLARREO will serve as an in-orbit, absolute, radiometric standard for the cross-calibration of hyperspectral radiance spectra observed by the international system of polar operational satellite sounding sensors. Here, we demonstrate that the resulting accurately cross-calibrated polar satellite global infrared spectral radiance trends (e.g., from the Metop IASI instrument considered here) can be interpreted in terms of temperature and water vapor profile trends. This demonstration is performed using atmospheric state data generated for a 100-year period from 2000-2099, produced by a numerical climate model prediction that was forced by the doubling of the global average atmospheric CO2 over the 100-year period. The vertical profiles and spatial distribution of temperature decadal trends were successfully diagnosed by applying a linear regression profile retrieval algorithm to the simulated hyperspectral radiance spectra for the 100-year period. These results indicate that it is possible to detect decadal trends in atmospheric climate variables from high accuracy all-sky satellite infrared radiance spectra using the linear regression retrieval technique

Pharmacological and behavioural interventions to promote smoking cessation in adults with schizophrenia and bipolar disorders: a systematic review and meta-analysis of randomised trials

Objective: Smoking in people with serious mental illness is a major public health problem and contributes to significant levels of morbidity and mortality. The aim of the review was to systematically examine the efficacy of methods used to aid smoking cessation in people with serious mental illness. Method: A systematic review and meta-analysis of randomised controlled trials to compare the effectiveness and safety of pharmacological and behavioural programmes for smoking cessation in people with serious mental illness. Electronic databases were searched for trials to July 2018. We used the Cochrane Collaboration’s tool for assessing the risk of bias. Results: Twenty-eight randomised controlled trials were identified. Varenicline increased the likelihood of smoking cessation at both 3 months (risk ratio (RR) 3.56, 95% CI 1.82 to 6.96, p=0.0002) and at 6 months (RR 3.69, 95% CI 1.08 to 12.60, p=0.04). Bupropion was effective at 3 months (RR 3.96, 95% CI 1.86 to 8.40, p=0.0003), especially at a dose of 300 mg/day, but there was no evidence of effect at 6 months (RR 2.22, 95% CI 0.52 to 9.47, p=0.28). In one small study, nicotine therapy proved effective at increasing smoking cessation up to a period of 3 months. Bupropion used in conjunction with nicotine replacement therapy showed more effect than single use. Behavioural and bespoke interventions showed little overall benefit. Side effects were found to be low. Conclusion: The new information of this review was the effectiveness of varenicline for smoking cessation at both 3 and 6 months and the lack of evidence to support the use of both bupropion and nicotine products for sustained abstinence longer than 3 months. Overall, the review found relatively few studies in this population

A Hierarchical Model and Analysis of Factors Affecting The Adoption of Timber as A Bridge Material

The Analytical Hierarchy Process was used to characterize the bridge material selection decisions of highway engineers and local highway officials across the United States. State Department of Transportation engineers, private consulting engineers, and local highway officials were personally interviewed in Mississippi, Virginia, Washington, and Wisconsin to identify how various factors determine their choice of a bridge material. The Analytical Hierarchy Process was used to quantify this subjective data and to model the selection decision for different groups of decision-makers. Prestressed concrete was the material of choice in the majority of cases. This was followed by reinforced concrete, steel, and timber. Local highway officials chose timber more often than did either group of engineers. These results indicate that timber will remain a niche market for bridge applications

Decay estimates for variable coefficient wave equations in exterior domains

In this article we consider variable coefficient, time dependent wave equations in exterior domains. We prove localized energy estimates if the domain is star-shaped and global in time Strichartz estimates if the domain is strictly convex.Comment: 15 pages. In the new version, some typos are fixed and a minor correction was made to the proof of Lemma 1

The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors

FMR1 encodes an RNA-binding protein whose absence results in fragile X mental retardation. In most patients, the FMR1 gene is cytosine-methylated and transcriptionally inactive. NRF-1 and Sp1 are known to bind and stimulate the active, but not the methylated/silenced, FMR1 promoter. Prior analysis has implicated a CRE site in regulation of FMR1 in neural cells but the role of this site is controversial. We now show that a phospho-CREB/ATF family member is bound to this site in vivo. We also find that the histone acetyltransferases CBP and p300 are associated with active FMR1 but are lost at the hypoacetylated fragile X allele. Surprisingly, FMR1 is not cAMP-inducible and resides in a newly recognized subclass of CREB-regulated genes. We have also elucidated a role for NRF-2 as a regulator of FMR1 in vivo through a previously unrecognized and highly conserved recognition site in FMR1. NRF-1 and NRF-2 act additively while NRF-2 synergizes with CREB/ATF at FMR1's promoter. These data add FMR1 to the collection of genes controlled by both NRF-1 and NRF-2 and disfavor its membership in the immediate early response group of genes

Optical Spectroscopy and Nebular Oxygen Abundances of the Spitzer/SINGS Galaxies

We present intermediate-resolution optical spectrophotometry of 65 galaxies obtained in support of the Spitzer Infrared Nearby Galaxies Survey (SINGS). For each galaxy we obtain a nuclear, circumnuclear, and semi-integrated optical spectrum designed to coincide spatially with mid- and far-infrared spectroscopy from the Spitzer Space Telescope. We make the reduced, spectrophotometrically calibrated one-dimensional spectra, as well as measurements of the fluxes and equivalent widths of the strong nebular emission lines, publically available. We use optical emission-line ratios measured on all three spatial scales to classify the sample into star-forming, active galactic nuclei (AGN), and galaxies with a mixture of star formation and nuclear activity. We find that the relative fraction of the sample classified as star-forming versus AGN is a strong function of the integrated light enclosed by the spectroscopic aperture. We supplement our observations with a large database of nebular emission-line measurements of individual HII regions in the SINGS galaxies culled from the literature. We use these ancillary data to conduct a detailed analysis of the radial abundance gradients and average HII-region abundances of a large fraction of the sample. We combine these results with our new integrated spectra to estimate the central and characteristic (globally-averaged) gas-phase oxygen abundances of all 75 SINGS galaxies. We conclude with an in-depth discussion of the absolute uncertainty in the nebular oxygen abundance scale.Comment: ApJS, in press; 52 emulateapj pages, 12 figures, and two appendices; v2: final abundances revised due to minor error; conclusions unchange

Retrograde transport pathways utilised by viruses and protein toxins

A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera toxin, Shiga and Shiga-like toxins, Pseudomonas exotoxin A and ricin, and compare the retrograde routes followed by these protein toxins to those of the ER trafficking SV40 and polyoma viruses. We conclude that there is in fact no obligatory requirement for a glycolipid receptor, nor even with a protein receptor in a lipid-rich environment. Emerging data suggests instead that there is no common pathway utilised for retrograde transport by all of these pathogens, the choice of route being determined by the particular receptor utilised