6,211 research outputs found
Sensitivity analysis of the space shuttle to ascent wind profiles
A parametric sensitivity analysis of the space shuttle ascent flight to the wind profile is presented. Engineering systems parameters are obtained by flight simulations using wind profile models and samples of detailed (Jimsphere) wind profile measurements. The wind models used are the synthetic vector wind model, with and without the design gust, and a model of the vector wind change with respect to time. From these comparison analyses an insight is gained on the contribution of winds to ascent subsystems flight parameters
Stream Water Quality to Support HUC 12 Prioritization in the Lake Wister Watershed, Oklahoma: August 2017 through May 2019
Nonpoint source pollution associated with human land use (agriculture and urbanization) is one of the leading causes of impairment to waterways in the United States (EPA 2000). The primary pollutants associated with agricultural and urban land use are sediment and nutrients which enter nearby streams during rain events and are then carried downstream. These sediments and nutrients may result in water quality issues in the downstream water bodies like increased algal growth or decreased water clarity (e.g. Smith et al., 1999). Best management practices (BMPs) are often used to mitigate the effects of nonpoint source pollution in the watershed. Practices such as riparian buffers installed along the edge of field and conservation tillage (e.g., no-till, spring-till, and cover crops) slow overland flow, reducing erosion and nutrient loss from the landscape (Schoumans et al. 2014). Installing BMPs throughout the entire watershed would have the greatest effect at reducing nonpoint source pollution; however, this is not socially or economically feasible. Targeting critical source areas or priority watersheds for BMPs installation, optimizes the benefits while reducing the overall (Sharpley et al. 2000)
Watershed Investigative Support to the Poteau Valley Improvement Authority: Stream Water Quality to Support HUC 12 Prioritization in the Lake Wister Watershed, Oklahoma
Nonpoint source pollution associated with human land use (agriculture and urbanization) is one of the leading causes of impairment to waterways in the United States (EPA, 2000). The primary pollutants associated with agricultural and urban land use are sediment and nutrients which enter nearby streams during rain events and are then carried downstream. These sediments and nutrients may result in water quality issues in the downstream water bodies like increased algal growth or decreased water clarity (e.g. Smith et al., 1999)
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.
Transcription factor Stat3 directs self-renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory factor (LIF). Stat3 upregulates pivotal transcription factors in the ES cell gene regulatory network to sustain naïve identity. Stat3 also contributes to the rapid proliferation of ES cells. Here, we show that Stat3 increases the expression of mitochondrial-encoded transcripts and enhances oxidative metabolism. Chromatin immunoprecipitation reveals that Stat3 binds to the mitochondrial genome, consistent with direct transcriptional regulation. An engineered form of Stat3 that localizes predominantly to mitochondria is sufficient to support enhanced proliferation of ES cells, but not to maintain their undifferentiated phenotype. Furthermore, during reprogramming from primed to naïve states of pluripotency, Stat3 similarly upregulates mitochondrial transcripts and facilitates metabolic resetting. These findings suggest that the potent stimulation of naïve pluripotency by LIF/Stat3 is attributable to parallel and synergistic induction of both mitochondrial respiration and nuclear transcription factors.GM’s laboratory is supported by grants from Armenise-Harvard Foundation and Telethon Foundation (TCP13013). The Cambridge Stem Cell Institute receives core funding from the Wellcome Trust and Medical Research Council. GM was supported by a Human Frontier Science Program Fellowship. AS is a Medical Research Professor.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.15252/embj.20159262
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency
Nurses\u27 Alumnae Association Bulletin - Volume 5 Number 8
Calling All Nurses
Financial Report
Calendar of Events
Lest You Forget!
Attention
Review of the Alumnae Association Meetings
President\u27s Report
Barton Memorial Division
Oxygen Therapy
Welcome, White Haven Alumnae
Clinical Use of Penicillin in Infections of the Ears, Nose and Throat
Address - Graduation of Nurses, 1945
Miscellaneous Items
The Blood that Kills
The Story of Malaria
Program
Prizes - May, 1946
Capping Exercises
The Economic Security Program of the Pennsylvania State Nurses\u27 Association
The Clara Melville Scholarship Fund
Card of Thanks
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The Hospital Pharmacy
Jefferson Medical College Hospital School of Nursing Faculty
Jefferson Hospital Gray Lady Unite, A.R.R.
The Volunteer Nurses\u27 Aides Salute Jefferson Nurses
Changes in the Staff at Jefferson Hospital
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Did You Know That
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Attention, Alumnae
New Addresse
In-cell thermodynamics and a new role for protein surfaces
Understanding protein thermodynamics as it occurs inside cells is a fundamental goal of biophysics, and, from a practical point of view, will facilitate the design and improvement of protein-based drugs and catalysts. By measuring the temperature dependence of protein stability inside Escherichia coli cells, we show, contrary to predictions, that proteins are not necessarily stabilized inside cells compared with buffer alone. We also show that crowding-induced charge–charge interactions slow folding because of preferential interactions with the unfolded ensemble, and reducing these interactions increases protein stability
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