84 research outputs found
The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01
Mobility on the Surface of Phobos for the MMX Rover - Simulation-aided Movement planning
The MMX Rover, recently named IDEFIX, will be the first wheeled robotic system to be operated in a milli-g environment. The mobility in this environment, particularly in combination with the interrupted communication schedule and the activation of on-board autonomous functions such as attitude control requires efficient planning. The Mobility Group within the MMX Rovers Team is tasked with proposing optimal solutions to move the rover safely and efficiently to its destination so that it may achieve its scientific goals. These movements combine various commands to the locomotion system and to the navigation systems developed by both institutions. In the mission's early phase, these actions will rely heavily on manual driving commands to the locomotion system until the rover behavior and environment assumptions are confirmed. Planning safe and efficient rover movements is a multi-step process. This paper focuses on the challenges and limitations in sequencing movements for a Rover on Phobos in the context of the MMX Mission. The context in which this process takes place is described in terms of available data and operational constraints
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.
The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease
Comparing after-ripening response and germination requirements of Conyza canadensis and C. bonariensis (Asteraceae) through logistic functions
Systematic Framework for Teleoperation with Haptic Shared Control
Teleoperation – performing tasks remotely by controlling a robot – permits the execution of many important tasks that would otherwise be infeasible for people to carry out directly. Nuclear accident recovery, deep water operations, and remote satellite servicing are just three examples. Remote task execution principally offers two extremes for control of the teleoperated robot: direct tele manipulation, which provides flexible task execution, but requires continuous operator attention, and automation, which lacks flexibility but offers superior performance in predictable and repetitive tasks (where the human assumes a supervisory role). This dissertation explores a third option, termed hap- tic shared control, which lies in-between these two extremes, and in which the control forces exerted by the human operator are continuously merged with ‘guidance’ forces generated by the automation. In a haptic shared control system, the operators continually contribute to the task execution, keeping their skills and situational awareness. It is common practice to design the haptic shared control systems heuristically, by iteratively adjusting them to the satisfaction of the system designer, primarily based on human-in- the-loop experiments. In this dissertation, we aim to improve this design and evaluation process. Our goal is to follow a system-theoretic approach and formalize the design procedures of haptic shared control systems applied to teleoperation. Such a formalization should provide designers of future HSC systems with a better understanding and more control over the design process, with the ultimate goal of making the HSC systems safer, easier and more intuitive to use, and overall to perform better. The research goal of this dissertation has been divided into three parts.Control & Simulatio
A new free floating satellite dynamics testbed for hardware-in-the-loop docking experiments
Control & SimulationBiomechatronics & Human-Machine Contro
Increasing impact by mechanical resonance for teleoperated hammering
Series elastic actuators (SEAs) are interesting for usage in harsh environments as they are more robust than rigid actuators. This paper shows how SEAs can be used in teleoperation to increase output velocity in dynamic tasks.A first experiment is presented that tested human ability to achieve higher hammerhead velocities with a flexible hammer than with a rigid hammer, and toevaluate the influence of the resonance frequency. In this experiment, 13 participants executed a hammering task in direct manipulation using flexible hammers in four conditions with resonance frequencies of 3.0 Hz to 9.9 Hz and one condition with a rigid hammer.Then, a second experiment is presented that tested the ability of 32 participants to reproduce the findings of the first experiment in teleoperated manipulation with different feedback conditions: with visual and force feedback, without visual feedback, without force feedback, and with a communication delay of 40 ms.The results indicate that humans can exploit the mechanical resonance of a flexible system to at least double the output velocity without combined force and vision feedback. This is an unexpected result, allowing the design of simpler and more robust teleoperators for dynamic tasks.Accepted Author Manuscript - Copyright 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Biomechatronics & Human-Machine ControlControl & Simulatio
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