51 research outputs found
The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.
The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease
Comparing after-ripening response and germination requirements of Conyza canadensis and C. bonariensis (Asteraceae) through logistic functions
Interactions of water, methanol and diethyl ether molecules with the surface of oxidized activated carbon
PREPARATION OF ACTIVATED CARBON FROM COCONUT SHELL IN A SMALL SCALE COCURRENT FLOW ROTARY KILN
Adsorption of water vapors and micropore structures of carbon adsorbents. 16. Comparative method of analysis of the structure of carbon adsorbents
Physiological versus non-physiological cardiac pacing as assessed by Ultra-high-frequency electrocardiography
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