2 research outputs found
Collaborative learning in academic English classroom: Preparation of PhD candidates
Academic English acquisition for PhD candidates is one of the main goals of higher
education modernization in Ukraine. Preparation of PhD candidates in postgraduate
studies is carried out through educational-scientific program and curriculum, and approved
by an academic council for each specialty. Academic English Program, designed by the
Department of Linguodidactics and Foreign Languages, Volodymyr Vynnychenko Central
Ukrainian State Pedagogical University, includes a course “Academic English”, the purpose
of which is to create necessary communicative ability for a scientist in oral and written
forms within the subject area of the individual research. To reach the purpose of the course
a collaborative learning Academic English class was created. The goals and processes of
collaborative activities in already designed small groups (3+4+4) were structured as such:
tightly structured tasks and creation of a clearly delineated product. The study incorporated
both group goals and individual accountability. Each member of the group received individual
task to contribute into the fulfilment of the group task. From this research study, it can be
concluded that collaborative learning fosters the development of critical thinking through
discussion, clarification of ideas, and evaluation of others’ ideas. The changing role of an
instructor as a facilitator involves creating and managing meaningful learning experiences
and stimulating PhD candidates’ thinking through real problems of their scientific research
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
BACKGROUND
Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent
ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride levels, but data
are needed to determine its effects on ischemic events.
METHODS
We performed a multicenter, randomized, double-blind, placebo-controlled trial involving
patients with established cardiovascular disease or with diabetes and other risk factors, who
had been receiving statin therapy and who had a fasting triglyceride level of 135 to 499 mg
per deciliter (1.52 to 5.63 mmol per liter) and a low-density lipoprotein cholesterol level of
41 to 100 mg per deciliter (1.06 to 2.59 mmol per liter). The patients were randomly assigned
to receive 2 g of icosapent ethyl twice daily (total daily dose, 4 g) or placebo. The primary
end point was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal
stroke, coronary revascularization, or unstable angina. The key secondary end point was a
composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke.
RESULTS
A total of 8179 patients were enrolled (70.7% for secondary prevention of cardiovascular
events) and were followed for a median of 4.9 years. A primary end-point event occurred in
17.2% of the patients in the icosapent ethyl group, as compared with 22.0% of the patients
in the placebo group (hazard ratio, 0.75; 95% confidence interval [CI], 0.68 to 0.83; P<0.001);
the corresponding rates of the key secondary end point were 11.2% and 14.8% (hazard ratio,
0.74; 95% CI, 0.65 to 0.83; P<0.001). The rates of additional ischemic end points, as assessed
according to a prespecified hierarchical schema, were significantly lower in the icosapent
ethyl group than in the placebo group, including the rate of cardiovascular death (4.3% vs.
5.2%; hazard ratio, 0.80; 95% CI, 0.66 to 0.98; P=0.03). A larger percentage of patients in
the icosapent ethyl group than in the placebo group were hospitalized for atrial fibrillation
or flutter (3.1% vs. 2.1%, P=0.004). Serious bleeding events occurred in 2.7% of the patients
in the icosapent ethyl group and in 2.1% in the placebo group (P=0.06).
CONCLUSIONS
Among patients with elevated triglyceride levels despite the use of statins, the risk of ischemic events, including cardiovascular death, was significantly lower among those who received 2 g of icosapent ethyl twice daily than among those who received placebo. (Funded
by Amarin Pharma; REDUCE-IT ClinicalTrials.gov number, NCT01492361