2 research outputs found
A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein
Extra-cellular matrix (ECM) components are important and their stabilization
is significant in maintaining normal healthy joint environment. In
osteoarthritis (OA), ECM components are altered and indicate disease
progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan,
inter a-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and
collagen types (most abundantly collagen type II) which represent structural
and functional transformation during disease advancement. ECM investigation
revealed significant biomarkers of OA that could be used as a diagnostic and
therapeutic tool in different canine orthopedic diseases. This review
deliberates our current findings of how the components of ECM change at the
molecular level during disease progression in canine OA