CONCEPTUAL MODEL OF AN IT-SOLUTIONS FOR PATENT RESEARCH AUTOMATION

The article is devoted to the development of a conceptual model patent of the patent analytics module integrated into the SAP corporate information system. It has been shown that patent research plays an important role in the strategic development of an enterprise based on the study of market trends. It has been proven that since the future strategy of the company depends on such a large dataset and the person is not able to assess the situation efficiently and consider a broad introduction, reengineering of the process of data collection and analysis is required, on which the fate of the enterprise depends. The primary purpose of this module is to provide automation of this kind of analysis and planning of strategic development of the enterprise. Moreover, the information collected by the system will help to correctly allocate funds for research and development programs

Vaccinal prevention of nodular dermatitis in Hereford cattle (clinical and immunological implications)

Animal vaccination is the principal method of preventing nodular dermatitis in cattle. Objective: to analyze the impact of using a specific transfer factor in vaccination of Hereford cattle against nodular dermatitis on the development of immunity and indices of animal homeostasis. Application of the transfer factor and the vitamin preparation Asidivit in the vaccination of animals against nodular dermatitis has reduced the reactogenicity of the vaccine in the form of a lower temperature reaction to the medicinal preparation of biological origin. The combined application of the immunoamplifier and Asidivit decreased the negative impact of vaccination on the liver of animals. The greatest quantitative decrease in bilirubin in the blood serum by 14% was observed. It made it possible to achieve a significant increase in antibodies in the blood serum by 72.4% compared to the initial analysis and an increase in the number of antibody-positive animals up to 80%

DBI (diazepam binding inhibitor): the precursor of a family of endogenous modulators of GABAA receptor function. History, perspectives, and clinical implications

Biochemical, electrophysiological, and lately, molecular biological techniques have shown that GABAA receptors are heterogeneous supramolecular complexes and can be divided into at least three major subgroups: GABAA1, GABAA2, and GABAA3. They differ mainly in the structural and functional properties of the allosteric modulatory center associated with each one of them. This paper will review the present state of research based on the evidence that DBI (diazepam binding inhibitor) and its natural processing products can selectively modulate GABAergic transmission at different GABAA receptor subtypes. Furthermore, the possibility that the DBI family of peptides represents a novel and meaningful neurochemical correlate for neuropsychiatric pathology, sustained by an alteration of GABAergic transmission, will be discussed

DBI (diazepam binding inhibitor): the precursor of a family of endogenous modulators of GABAA receptor function. History, perspectives, and clinical implications

Biochemical, electrophysiological, and lately, molecular biological techniques have shown that GABAA receptors are heterogeneous supramolecular complexes and can be divided into at least three major subgroups: GABAA1, GABAA2, and GABAA3. They differ mainly in the structural and functional properties of the allosteric modulatory center associated with each one of them. This paper will review the present state of research based on the evidence that DBI (diazepam binding inhibitor) and its natural processing products can selectively modulate GABAergic transmission at different GABAA receptor subtypes. Furthermore, the possibility that the DBI family of peptides represents a novel and meaningful neurochemical correlate for neuropsychiatric pathology, sustained by an alteration of GABAergic transmission, will be discussed

Freeze-fracture immunocytochemical study of the expression of native and recombinant GABAA receptors

To assess the density and distribution of native and recombinant GABAA receptors we used label-fracture and fracture-flip technologies combined with immunocytochemistry using monoclonal and polyclonal Abs directed against the extracellular domain of the GABAA receptor protein located in the freeze-fracture replicas. In cortical neurons there is a high density of GABAA receptors on both soma and dendrites with some areas were the density of receptors is higher, but there are no well defined clusters. In cerebellar granule cells most of the receptors are distributed in round clusters both in neurites and soma. In astroglial cells the receptor density is lower than in neurons and only occasionally they appear in clusters. In cells transfected with cDNAs encoding for various molecular forms of GABAA receptor subunits, the receptor density is moderate when cDNAs for \u3b1, \u3b2 and \u3b3 subnits are cotransfected; however, on cells cotransfected with cDNAs for \u3b2 and \u3b3 subunits the receptor density is significantly lower. Recombinant receptors appear randomly distributed and occasionally they aggregate in small groups. \ua9 1993