Flexurally-resisted uplift of the Tharsis Province, Mars

The tectonic style of Mars is dominated by vertical motion, perhaps more than any of the terrestrial planets. The imprint of this tectonic activity has left a surface widely faulted even though younger volcanism has masked the expression of tectonism in many places. Geological activity associated with the Tharsis and, to a lesser extent, Elysium provinces is responsible for a significant portion of this faulting, while the origins of the remaining features are enigmatic in many cases. The origin and evolution of the Tharsis and Elysium provinces, in terms of their great elevation, volcanic activity, and tectonic style, has sparked intense debate over the last fifteen years. Central to these discussions are the relative roles of structural uplift and volcanic construction in the creation of immense topographic relief. For example, it is argued that the presence of very old and cratered terrain high on the Tharsis rise, in the vicinity of Claritas Fossae, points to structural uplift of an ancient crust. Others have pointed out, however, that there is no reason that this terrain could not be of volcanic origin and thus part of the constructional mechanism

Impact production of NO and reduced species

It has recently been suggested that a reported spike in seawater (87)Sr/(86)Sr at the K-T boundary is the signature of an impact-generated acid deluge. However, the amount of acid required is implausibly large. Some about 3 x 10 to the 15th power moles of Sr must be weathered from silicates to produce the inferred Sr spike. The amount of acid required is at least 100 and probably 1000 times greater. Production of 3 x 10 to the 18th power moles of NO is clearly untenable. The atmosphere presently contains only 1.4 x 10 to the 20th power moles of N-sub 2 and 3.8 x 10 to the 19th power moles of O sub 2 If the entire atmosphere were shocked to 2000 K and cooled within a second, the total NO produced would be about 3 x 10 to the 18th power moles. This is obviously unrealistic. A (still to short) cooling time of 10th to the 3rd power sec reduces NO production by an order of magnitude. In passing, we note that if the entire atmosphere had in fact been shocked to 2000 K, acid rain would have been the least of a dinosaur's problems. Acid rain as a mechanism poses poses other difficulties. Recently deposited carbonates would have been most susceptable to acid attack. The researchers' preferred explanation is simply increased continental erosion following ecological trauma, coupled with enchanced levels of CO-sub 2

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle.

The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was covalently modified with iodoacetamidotetramethylrhodamine (iodo-ATR). Native RLC of single glycerinated muscle fibers was exchanged for labeled cgRLC in a low [Mg2+] rigor solution at 30 degrees C. Troponin and troponin C removed in this procedure were replaced. RLC exchange had little effect on active force production. X-ray diffraction showed normal structure in rigor after RLC exchange, but loss of axial and helical order in relaxation. In isolated myofibrils labeled cgRLC was confined to the regions of the sarcomere containing myosin heads. The ATR dipoles showed a preference for orientations perpendicular to the fiber axis, combined with limited nanosecond rotational motion, in all conditions studied. The perpendicular orientation preference was more marked in rigor than in either relaxation or active contraction. Stretching relaxed fibers to sarcomere length 4 microns to eliminate overlap between actin- and myosin-containing filaments had little effect on the orientation preference. There was no change in orientation preference when fibers were put into rigor at sarcomere length 4.0 microns. Qualitatively similar results were obtained with ATR-labeled rabbit skeletal RLC

Origin and thermal evolution of Mars

The thermal evolution of Mars is governed by subsolidus mantle convection beneath a thick lithosphere. Models of the interior evolution are developed by parameterizing mantle convective heat transport in terms of mantle viscosity, the superadiabatic temperature rise across the mantle, and mantle heat production. Geological, geophysical, and geochemical observations of the compositon and structure of the interior and of the timing of major events in Martian evolution are used to constrain the model computations. Such evolutionary events include global differentiation, atmospheric outgassing, and the formation of the hemispherical dichotomy and Tharsis. Numerical calculations of fully three-dimensional, spherical convection in a shell the size of the Martian mantle are performed to explore plausible patterns of Martian mantel convection and to relate convective features, such as plumes, to surface features, such as Tharsis. The results from the model calculations are presented

Best Practices in Second Stage Labor Care: Maternal Bearing Down and Positioning

Despite evidence of adverse fetal and maternal outcomes from the use of sustained Valsalva bearing down efforts, current second-stage care practices are still characterized by uniform directions to “push” forcefully upon complete dilatation of the cervix while the woman is in a supine position. Directed pushing might slightly shorten the duration of second stage labor, but can also contribute to deoxygenation of the fetus; cause damage to urinary, pelvic, and perineal structures; and challenge a woman’s confidence in her body. Research on the second stage of labor care is reviewed, with a focus on recent literature on maternal bearing down efforts, the “laboring down” approach to care, second-stage duration, and maternal position. Clinicians can apply the scientific evidence regarding the detrimental effects of sustained Valsalva bearing down efforts and supine positioning by individualizing second stage labor care and supporting women’s involuntary bearing down sensations that can serve to guide her behaviors

Comparison of Upscaled Models for Multistage Mass Discharge from DNAPL Source Zones

Analytical upscaled models that can describe the depletion of dense nonaqueous phase liquids (DNAPLs) and the associated mass discharge are a practical alternative to computationally demanding and data-intensive multiphase numerical simulators. A major shortcoming of most existing upscaled models is that they cannot reproduce the nonmonotonic, multistage effluent concentrations often observed in experiments and numerical simulations. Upscaled models that can produce multistage concentrations either require calibration, which increases the cost of applying them in the field, or use dual-domain conceptual models that may not apply for spatially complex source zones. In this study, a new upscaled model is presented that can describe the nonmonotonic, multistage average concentrations emanating from complex DNAPL source zones. This is achieved by explicitly considering the temporal evolution of three source zone parameters, namely source zone projected area, the average of local-scale DNAPL saturations, and the average of local-scale aqueous relative permeability, without using empirical parameters. The model is evaluated for two real and twelve hypothetical centimeter-scale complex source zones. The proposed model captures the temporal variations in concentrations better than an empirical model and a dual-domain ganglia- to-pool ratio model. The results provide evidence that effluent concentrations downgradient of DNAPL source zones are controlled by the evolution of the aforementioned macroscopic parameters. This knowledge can be useful for the interpretation of field observations of effluent concentrations downstream of DNAPL source zones, and for the development of predictive upscaled models. Advances in DNAPL characterization techniques are needed to quantify these macroscopic parameters that can be used to guide DNAPL remediation efforts

Coupled Simulation of DNAPL Infiltration and Dissolution in Three-Dimensional Heterogeneous Domains: Process Model Validation

A three-dimensional multiphase numerical model was used to simulate the infiltration and dissolution of a dense nonaqueous phase liquid (DNAPL) release in two experimental flow cells containing different heterogeneous and well-characterized permeability fields. DNAPL infiltration was modeled using Brooks-Corey-Burdine hysteretic constitutive relationships. DNAPL dissolution was simulated using a rate-limited mass transfer expression with a velocity-dependent mass transfer coefficient and a thermodynamically based calculation of DNAPL-water interfacial area. The model did not require calibration of any parameters. The model predictions were compared to experimental measurements of high-resolution DNAPL saturations and effluent concentrations. The predicted concentrations were in close agreement with measurements for both domains, indicating that important processes were effectively captured by the model. DNAPL saturations greatly influenced mass transfer rates through their effect on relative permeability and velocity. Areas with low DNAPL saturation were associated with low interfacial areas, which resulted in reduced mass transfer rates and nonequilibrium dissolution. This was captured by the thermodynamic interfacial area model, while a geometric model overestimated the interfacial areas and the overall mass transfer. This study presents the first validation of the thermodynamic dissolution model in three dimensions and for high aqueous phase velocities; such conditions are typical for remediation operations, especially in heterogeneous aquifers. The demonstrated ability to predict DNAPL dissolution, only requiring prior characterization of soil properties and DNAPL release conditions, represents a significant improvement compared to empirical dissolution models and provides an opportunity to delineate the relationship between source zone architecture and the remediation potential for complex DNAPL source zones

Position paper on the use of mandibular advancement devices in adults with sleep-related breathing disorders: A position paper of the German Society of Dental Sleep Medicine (Deutsche Gesellschaft Zahnaerztliche Schlafmedizin, DGZS)

Custom-made mandibular advancement devices are an effective treatment option for snoring, upper airway resistance syndrome, and obstructive sleep apnea (OSA). Evidence-based data indicates their efficacy, and international sleep societies recommend oral appliance (OA) therapy for patients with sleep-related breathing disorders. The following position paper by the German Society of Dental Sleep Medicine (DGZS) is to guide the interdisciplinary team (sleep physician and sleep disorder dentist) in detail when to prescribe oral appliances. This position paper supports the responsible use of OA as an effective treatment option for patients with sleep-related breathing disorders. The paper advises of proper indication regarding OSA severity, body mass index (BMI), and dentition. It emphasizes the interdisciplinary approach of oral appliance therapy and suggests treatment under the guidance of dentists trained in dental sleep medicine