Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb

Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ganglionic eminence (LGE) and the cerebral cortex, contribute multipotent, self-renewing stem cells to the adult SVZ. Descendants of the embryonic LGE and cortex settle in ventral and dorsal aspects of the dorsolateral SVZ, respectively. Both populations contribute new (5-bromo-2(')-deoxyuridine- labeled) tyrosine hydroxylase- and calretinin-positive interneurons to the adult olfactory bulb. However, calbindin-positive interneurons in the olfactory glomeruli were generated exclusively by LGE- derived stem cells. Thus, different SVZ stem cells have different embryonic origins, colonize different parts of the SVZ, and generate different neuronal progeny, suggesting that some aspects of embryonic patterning are preserved in the adult SVZ. This could have important implications for the design of endogenous stem cell-based therapies in the future

Realistic lower bounds for the factorization time of large numbers on a quantum computer.

Published versio

A quantum-mechanical Maxwell's demon

A Maxwell's demon is a device that gets information and trades it in for thermodynamic advantage, in apparent (but not actual) contradiction to the second law of thermodynamics. Quantum-mechanical versions of Maxwell's demon exhibit features that classical versions do not: in particular, a device that gets information about a quantum system disturbs it in the process. In addition, the information produced by quantum measurement acts as an additional source of thermodynamic inefficiency. This paper investigates the properties of quantum-mechanical Maxwell's demons, and proposes experimentally realizable models of such devices.Comment: 13 pages, Te

Multi-valued Logic Gates for Quantum Computation

We develop a multi-valued logic for quantum computing for use in multi-level quantum systems, and discuss the practical advantages of this approach for scaling up a quantum computer. Generalizing the methods of binary quantum logic, we establish that arbitrary unitary operations on any number of d-level systems (d > 2) can be decomposed into logic gates that operate on only two systems at a time. We show that such multi-valued logic gates are experimentally feasible in the context of the linear ion trap scheme for quantum computing. By using d levels in each ion in this scheme, we reduce the number of ions needed for a computation by a factor of log d.Comment: Revised version; 8 pages, 3 figures; to appear in Physical Review

Noise spectroscopy of a single spin with spin polarized STM

We show how the noise in a spin polarized STM tunneling current gives valuable spectroscopic information on the temporal susceptibility of a single magnetic atom residing on a non-magnetic surface.Comment: 6 pages, 1 figure. To appear in Physical Review

Rotational Cooling of Polar Molecules by Stark-tuned Cavity Resonance

A general scheme for rotational cooling of diatomic heteronuclear molecules is proposed. It uses a superconducting microwave cavity to enhance the spontaneous decay via Purcell effect. Rotational cooling can be induced by sequentially tuning each rotational transition to cavity resonance, starting from the highest transition level to the lowest using an electric field. Electrostatic multipoles can be used to provide large confinement volume with essentially homogeneous background electric field.Comment: 10 pages, 6 figure

Measurement of conditional phase shifts for quantum logic

Measurements of the birefringence of a single atom strongly coupled to a high-finesse optical resonator are reported, with nonlinear phase shifts observed for intracavity photon number much less than one. A proposal to utilize the measured conditional phase shifts for implementing quantum logic via a quantum-phase gate (QPG) is considered. Within the context of a simple model for the field transformation, the parameters of the "truth table" for the QPG are determined.Comment: 4 pages in Postscript format, including 4 figures (attached as uuencoded version of a gzip-file

Recurrences in Driven Quantum Systems

We consider an initially bound quantum particle subject to an external time-dependent field. When the external field is large, the particle shows a tendency to repeatedly return to its initial state, irrespective of whether the frequency of the field is sufficient for escape from the well. These recurrences, which are absent in a classical calculation, arise from the system evolving primarily like a free particle in the external field.Comment: 10 pages in RevTeX format, with three PS files appende

Probabilistic manipulation of entangled photons

We propose probabilistic controlled-NOT and controlled-phase gates for qubits stored in the polarization of photons. The gates are composed of linear optics and photon detectors, and consume polarization entangled photon pairs. The fraction of the successful operation is only limited by the efficiency of the Bell-state measurement. The gates work correctly under the use of imperfect detectors and lossy transmission of photons. Combined with single-qubit gates, they can be used for producing arbitrary polarization states and for designing various quantum measurements.Comment: 4 pages, 3 figure

Factoring in a Dissipative Quantum Computer

We describe an array of quantum gates implementing Shor's algorithm for prime factorization in a quantum computer. The array includes a circuit for modular exponentiation with several subcomponents (such as controlled multipliers, adders, etc) which are described in terms of elementary Toffoli gates. We present a simple analysis of the impact of losses and decoherence on the performance of this quantum factoring circuit. For that purpose, we simulate a quantum computer which is running the program to factor N = 15 while interacting with a dissipative environment. As a consequence of this interaction randomly selected qubits may spontaneously decay. Using the results of our numerical simulations we analyze the efficiency of some simple error correction techniques.Comment: plain tex, 18 pages, 8 postscript figure