Navika tjelesne aktivnosti kod autora koji su objavljivali u Hrvatskom časopisu za javno zdravstvo

Navike se mogu definirati kao stečeni oblik ponašanja. Navike nastaju višestrukim, višegodišnjim, ponavljanjem odgovarajućih pokreta ili radnji. Postoje razne vrste navika npr. navike ponašanja, higijenske navike, radne navike itd. Neke od njih su pozitivne, a neke negativne. Tjelesna aktivnost je primjer pozitivne navike, koja pridonosi poboljšanju psiho-fizičkog stanja čovjeka, te je stog vrlo važna u primarnoj prevenciji niza kroničnih i akutnih bolesti. Da bi se stvorila navika redovitog tjelesnog vježbanja potrebno je, unatoč fizičkom zamoru koji proizlazi iz same aktivnosti, ponavljati odgovarajuće vježbe ili aktivnosti iz dana u dan, iz godine u godinu. Kada organizam počne prepoznavati umor u vrijeme treninga, a pogotovo nakon treninga, kao vrhunac ugode, tada možete biti sigurni da ste ovisnik o jednoj pozitivnoj navici- tjelesnoj aktivnosti.

Navika tjelesne aktivnosti kod autora koji su objavljivali u Hrvatskom časopisu za javno zdravstvo

Navike se mogu definirati kao stečeni oblik ponašanja. Navike nastaju višestrukim, višegodišnjim, ponavljanjem odgovarajućih pokreta ili radnji. Postoje razne vrste navika npr. navike ponašanja, higijenske navike, radne navike itd. Neke od njih su pozitivne, a neke negativne. Tjelesna aktivnost je primjer pozitivne navike, koja pridonosi poboljšanju psiho-fizičkog stanja čovjeka, te je stog vrlo važna u primarnoj prevenciji niza kroničnih i akutnih bolesti. Da bi se stvorila navika redovitog tjelesnog vježbanja potrebno je, unatoč fizičkom zamoru koji proizlazi iz same aktivnosti, ponavljati odgovarajuće vježbe ili aktivnosti iz dana u dan, iz godine u godinu. Kada organizam počne prepoznavati umor u vrijeme treninga, a pogotovo nakon treninga, kao vrhunac ugode, tada možete biti sigurni da ste ovisnik o jednoj pozitivnoj navici- tjelesnoj aktivnosti.

Drought Impact Is Alleviated in Sugar Beets (Beta vulgaris L.) by Foliar Application of Fullerenol Nanoparticles

Over the past few years, significant efforts have been made to decrease the effects of drought stress on plant productivity and quality. We propose that fullerenol nanoparticles (FNPs, molecular formula C-60(OH)(24)) may help alleviate drought stress by serving as an additional intercellular water supply. Specifically, FNPs are able to penetrate plant leaf and root tissues, where they bind water in various cell compartments. This hydroscopic activity suggests that FNPs could be beneficial in plants. The aim of the present study was to analyse the influence of FNPs on sugar beet plants exposed to drought stress. Our results indicate that intracellular water metabolism can be modified by foliar application of FNPs in drought exposed plants. Drought stress induced a significant increase in the compatible osmolyte proline in both the leaves and roots of control plants, but not in FNP treated plants. These results indicate that FNPs could act as intracellular binders of water, creating an additional water reserve, and enabling adaptation to drought stress. Moreover, analysis of plant antioxidant enzyme activities (CAT, APx and GPx), MDA and GSH content indicate that fullerenol foliar application could have some beneficial effect on alleviating oxidative effects of drought stress, depending on the concentration of nanoparticles applied. Although further studies are necessary to elucidate the biochemical impact of FNPs on plants; the present results could directly impact agricultural practice, where available water supplies are often a limiting factor in plant bioproductivity

The anti-oxidative defence system in the isolated rat uterus during spontaneous rhythmic activity

Possible interactions between nitric oxide donors, reactive oxygen species and anti-oxidative defence enzymes led us to determine the activities of anti-oxidative defence enzymes in isolated uterine smooth muscle before and after spontaneous rhythmic activity ex vivo. For our experiments we used isolated uteri from female Wistar rats. Our results showed an increase in total superoxide dismutase (SOD) and Mn SOD activities in uterine smooth muscle after spontaneous contractions when compared with non-exercised uterine smooth muscle. The activity of catalase (CAT) and glutathione preoxidase (GSH-Px) were also increased. No statistically significant changes in the activities of glutathione reductase (GR) and CuZn SOD were found. It is known that an organism's anti-oxidative defence system (guarding against excessive reactive oxygen species generation) requires balanced increments in its individual anti-oxidative enzyme activities rather than increases in the activity of only some enzymes without increases in others. Thus, we may conclude that some adaptive responses are found in exercised uterine smooth muscle but are not complete. Therefore, our results indicate that changes in anti-oxidative enzyme activities may influence the results of the examination of substances ex vivo

Erythrocyte SOD1 activity-role in bioavailability of NO and possible cause of 'duing back' phenomena in neurodegenerative diseases

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Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells

Fullerenol (C60(OH)24) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which are cytoprotective and antioxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influence the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.[Projekat Ministarstva nauke Republike Srbije, br. III45005 i Pokrajinski Sekretarijat za nauku i tehnološki razvoj Vojvodine, grant number 114-451-2056/2011-01

Tianeptine’s effects on spontaneous and Ca2+-induced uterine smooth muscle contraction

Tianeptine is a novel anti-depressant with an efficacy equivalent to that of classical anti-depressants. Additional beneficial effects include neuroprotection, anti-stress and anti-ulcer properties whose molecular mechanisms are still not completely understood but may involve changes in the anti-oxidant defence system. Herein, we have studied the effects of tianeptine on both contractile activity of isolated rat uteri and components of the endogenous anti-oxidative defence system. Tianeptine-induced dose-dependent inhibition of both spontaneous and Ca2+-induced contraction of uterine smooth muscle. The effect was more pronounced in the latter. Tianeptine treatment increased glutathioneperoxidase (GSH-Px) and catalase (CAT) activities in spontaneous and Ca2+-stimulated uteri. A significant decrease in glutathione-reductase (GR) activity in both spontaneous and Ca2+-induced uterine contractions after tianeptine treatment indicated a reduction in reduced glutathione and consequently a shift toward a more oxidised state in the treated uteri. In spontaneously contracting uteri, tianeptine caused a decrease in copper-zinc SOD (CuZnSOD) activity. Tianeptine’s anti-depressant effects may be accomplished by triggering a cascade of cellular adaptations including inhibition of smooth muscle contractility and an adequate anti-oxidative protection response

Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction

Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.Ministry of Education, Science and Technological Development of the Republic of Serbia [173014B, III45005