1,436 research outputs found
Coagulation changes and the influence of the early perfusate in the course of orthotopic liver transplantation (OLT) when aprotinin is used intraoperatively
Multiple Reflections and Diffuse Scattering in Bragg Scattering at Optical Lattices
We study Bragg scattering at 1D atomic lattices. Cold atoms are confined by
optical dipole forces at the antinodes of a standing wave generated inside a
laser-driven cavity. The atoms arrange themselves into an array of lens-shaped
layers located at the antinodes of the standing wave. Light incident on this
array at a well-defined angle is partially Bragg-reflected. We measure
reflectivities as high as 30%. In contrast to a previous experiment devoted to
the thin grating limit [S. Slama, et al., Phys. Rev. Lett. 94, 193901 (2005)]
we now investigate the thick grating limit characterized by multiple
reflections of the light beam between the atomic layers. In principle multiple
reflections give rise to a photonic stop band, which manifests itself in the
Bragg diffraction spectra as asymmetries and minima due to destructive
interference between different reflection paths. We show that close to
resonance however disorder favors diffuse scattering, hinders coherent multiple
scattering and impedes the characteristic suppression of spontaneous emission
inside a photonic band gap
Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation
Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase.
We investigated the role of leukocytes in the pathogenesis of DIC in OLT by measuring the leukocytic mediators released upon activation (cathepsin B, elastase, TNF, neopterin) and the levels of thrombin-antithrombin III (TAT) complexes, seen as markers of prothrombin activation. Arterial blood samples were taken at 10 different time points during and after OLT. Samples were also taken of the perfusate released from the liver graft vein during the flushing procedure before the reperfusion phase. Aprotinin was given as a continuous infusion (0.2-0.4 Mill. KlU/hr) and its plasma levels were determined.
Significantly elevated levels of neopterin (15-fold; P<0.01), cathepsin B (440-fold; P<0.01) in the perfusate, as compared with the systemic circulation, as well as their significant increases in the early reperfusion phase suggested that they were released by the graft liver. This was paralleled by elevated levels of elastase (1.3-fold, P<0.05), TNF (1.5-fold, P=NS), and TAT complexes (1.4-fold; P<0.1) in the perfusate. Significant correlations could be identified between the parameters of leukocyte activation and TAT complexes, whereas no correlation was observed between any of the parameters investigated and the aprotinin levels.
Our results strongly indicate a release of leukocytic mediators from the graft liver during its reperfusion which seems to be related to the parallely increased prothrombin activation. No correlation could be seen between levels of aprotinin and levels of leukocytic mediators
Different aprotinin applications influencing hemostatic chances in orthotopic liver transplantation
The effect of different aprotinin applications on hemmtatic changes and blood product requirements in orthotopic liver transplantation was investigated in a prospective, open, and randomized study.
From November 1989 to June 1990, 13 patients received aprotinin as a bolus of 0.5 Mill, kallikrein inac-tivator units (KIU) on three occasions in the course of an OLT, whereas 10 other patients were treated with continuous aprotinin infusion of 0.1-0.4 Mill. KIU/hr. Before and after reperfusion of the graft liver, signs of hyperfibrinolysis, measured by thrombelastography, were significantly lower in the infusion group. Tissue-type plasminogen activator (t-PA) activity increased during the anhepatic phase but to a significantly lesser extent in the infusion group. Blood product requirements during OLT were tendentiously higher in the bolus group but not significantly so. However, the use of packed red blood cells was significantly lower in the postoperative period, whereas there was no significant difference in fresh frozen plasma requirements between the two groups.
All 23 patients have survived, and only one woman of each group required retransplantation due to severe host-versus-graft reactions.
Furthermore, we investigated the perfusate of the graft liver in both groups and detected signs of a decreased t-PA release in the infusion group.
Our results demonstrate an advantage of aprotinin given as continuous infusion over bolus application in OLT
Ultra-cold atoms in an optical cavity: two-mode laser locking to the cavity avoiding radiation pressure
The combination of ultra-cold atomic clouds with the light fields of optical
cavities provides a powerful model system for the development of new types of
laser cooling and for studying cooperative phenomena. These experiments
critically depend on the precise tuning of an incident pump laser with respect
to a cavity resonance. Here, we present a simple and reliable experimental
tuning scheme based on a two-mode laser spectrometer. The scheme uses a first
laser for probing higher-order transversal modes of the cavity having an
intensity minimum near the cavity's optical axis, where the atoms are confined
by a magnetic trap. In this way the cavity resonance is observed without
exposing the atoms to unwanted radiation pressure. A second laser, which is
phase-locked to the first one and tuned close to a fundamental cavity mode
drives the coherent atom-field dynamics.Comment: 7 pages, 7 figure
K vprašanju kavri polžev v slovanskih najdbah
Entre les siècles Vfflème et XIIèm« il y avait, à tout prendre, une grande quan[1]tité de cauris. En Russie les fouilles se trouvent dans deux zones. La zone sud s’étend depuis la ville de Tambovsk par l’Ukraine west et par l’Ukraine nord. La zone nord va de Vladimir jusqu’aux pays littoraux au nord-ouest de Novgorod. 11 y avait des groupes indépendants dans le Bassin des Carpathes, en Autriche et en Bohême. En Russie les fouilles plus anciennes se trouvent dans la zone sud (VIIIème— IXème siècles), tandis qu’on trouve les plus récentes dans la zone nord. Les fouilles du Bassin des Carpathes, celles de la plaine de Pannonie et celles de la culture de Belo brdo appartienne au Xème siècle et à une époque postérieure. Les cauris en Europe doivent être considérés comme articles importés. Il y a un con[1]sidérable écart de vue quant aux voies commerciales. Il n’est pas exclu que les cauris du Bassin des Carpathes soient parvenus de l’Europe orientale. On peut admettre que les fouilles de la Bohême soient en rapport avec le Bassin des Car[1]pathes et avec la culture de Belo brdo respectivement. La grande quantité de cauris parmi les fouilles slaves des IXème— X I™ ' sièçles peut sans doute trouver une explication satisfaisante dans les relations commerciales ranimées avec le Sud-Est, territoire alors tombe dans la domaine des Arabes. La question à quelle fin les cauris eussent été utilisés est encore en suspens
Dimensional Crossover in Bragg Scattering from an Optical Lattice
We study Bragg scattering at 1D optical lattices. Cold atoms are confined by
the optical dipole force at the antinodes of a standing wave generated inside a
laser-driven high-finesse cavity. The atoms arrange themselves into a chain of
pancake-shaped layers located at the antinodes of the standing wave. Laser
light incident on this chain is partially Bragg-reflected. We observe an
angular dependence of this Bragg reflection which is different to what is known
from crystalline solids. In solids the scattering layers can be taken to be
infinitely spread (3D limit). This is not generally true for an optical lattice
consistent of a 1D linear chain of point-like scattering sites. By an explicit
structure factor calculation we derive a generalized Bragg condition, which is
valid in the intermediate regime. This enables us to determine the aspect ratio
of the atomic lattice from the angular dependance of the Bragg scattered light.Comment: 4 pages, 5 figure
Quit Smoking and Run For Your Life!
To The Editor: The World Health Organization promotes the World No Tobacco Day on May 31
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