Giant aneurysmal bone cyst mimicking malignant tumor

Aneurysmal bone cyst (ABC) is a bone tumor which occurs mostly in young adults. Despite its benign character, it may sometimes locally turn malignant and can reach a significant size. Therefore, it is not uncommon for this disease to become similar to a malignant, destructive process and to be difficult to diagnose. We present a case of a 12-year-old girl with a rapidly growing mass in the region of the left hip joint. Imaging (X-ray, MRI, CT) showed a growing lesion in the proximal part of the femur that damaged the cortical layer of the bone. This suggested a presence of rhabdomyosarcoma. The lesion was removed surgically and the bone defects were filled with grafts. Two months after the surgery the patient reported pain in the area of the right groin and left knee. X-ray showed bone lesions in the right pubic bone and the left femoral bone. The biopsy showed no pathological lesions. One year after the surgery, lesions in the X-ray image of the right pubic bone and left femoral bone remitted spontaneously. Ten years after the diagnosis of the aneurysmal bone cyst no recurrence of the disease or other ailments was observed

Factores que afectan la ingesta de productos lácteos fermentados entre estudiantes universitarios: un estudio transversal de Polonia y Turquía

Introduction: The aim of the study is to present fermented milk products intake and related factors by Turkish and Polish students of dietetics.Material and methods: Dietetics students of both Medical University of Silesia in Katowice (SUM), Poland and Izmir Katip Celebi University in Izmir (IKCU), Turkey were kindly requested to fill up an on-line questionnaire. The questionnaire consisted of 23 questions about personal data, consumer preferences, substantive knowledge and assessment of factors conditioning the purchase of fermented milk products. Statistical significance between the groups were checked with the Mann-Whitney U test, t test and Chi squared χ2 test.  A statistically significant difference met the p<0.05 condition.Results: There were 162 Polish and 181 Turkish respondents taking part in the research. The most common fermented milk product among both the SUM and IKCU students was plain yoghurt. Its intake was declared by over 95% of the respondents in both groups. In the group of the Polish students, fermented milk products are consumed mainly for breakfast (61.11%) and as a snack between meals (58.02%). Turkish students significantly more frequently prefer to eat them for dinner (50.28%) and lunch (48%). Only 21.06% of the Polish students and 29.3% of the Turkish students consume fermented milk products every day. Products with no colour additives and preservatives are selected by 67.9% of the SUM students, while IKCU students more often choose products with probiotics and prebiotics (43.10%) as well as products with reduced fat content (40.3%). Quality, composition of products, manufacturer, packaging, advertisement were determined the significant factors that preconditioning the selection of fermented milk products.Conclusions: Cultural differences concerning fermented milk products are reflected in eating habits and consumer preferences. Plain yoghurt is a frequently chosen product by both the SUM and IKCU students. There were differences between the respondents in terms of times of the day, amount and types of consumed fermented milk products. Moreover, factors preconditioning their selection vary between the two groups.Introducción: El objetivo del estudio es presentar la ingesta de productos lácteos fermentados y factores relacionados por estudiantes de dietética turcos y polacos.Material y métodos: Se solicitó a los estudiantes de dietética de la Universidad de Medicina de Silesia en Katowice (SUM), Polonia, y de la Universidad de Esmirna Katip Celebi en Izmir (IKCU), Turquía, que llenaran un cuestionario en línea. El cuestionario constaba de 23 preguntas sobre datos personales, preferencias del consumidor, conocimiento sustantivo y evaluación de factores que condicionan la compra de productos lácteos fermentados. La significación estadística entre los grupos se verificó con la prueba U de Mann-Whitney, la prueba t y la prueba de Chi cuadrado χ2. La diferencia estadísticamente significativa cumplió la condición p <0,05.Resultados: Hubo 162 encuestados polacos y 181 turcos que participaron en la investigación. El producto lácteo fermentado más común entre los estudiantes de SUM e IKCU fue el yogur natural. Su consumo fue declarado por más del 95% de los encuestados en ambos grupos. En el grupo de estudiantes polacos, los productos lácteos fermentados se consumen principalmente para el desayuno (61,11%) y como refrigerio entre comidas (58,02%). Los estudiantes turcos prefieren comerlos con mucha más frecuencia para la cena (50,28%) y el almuerzo (48%). Solo el 21,06% de los estudiantes polacos y el 29,3% de los estudiantes turcos consumen productos lácteos fermentados todos los días. Los productos sin aditivos colorantes ni conservantes son seleccionados por el 67,9% de los estudiantes de SUM, mientras que los estudiantes de IKCU a menudo eligen productos con probióticos y prebióticos (43,10%), así como productos con contenido reducido de grasa (40,3%). La calidad, la composición de los productos, el fabricante, el embalaje, la publicidad se determinaron los factores importantes que condicionan previamente la selección de productos lácteos fermentados.Conclusiones: las diferencias culturales con respecto a los productos lácteos fermentados se reflejan en los hábitos alimenticios y las preferencias de los consumidores. El yogur natural es un producto frecuentemente elegido por los estudiantes de SUM e IKCU. Hubo diferencias entre los encuestados en términos de horas del día, cantidad y tipos de productos lácteos fermentados consumidos. Además, los factores que condicionan previamente su selección varían entre los dos grupos

Ochrona środowiska przed elektromagnetycznym promieniowaniem niejonizującym. Telekomunikacja i Techniki Informacyjne, 2010,nr 3-4

Opisano oddziaływanie pola elektromagnetycznego pochodzącego z różnych źródeł na organizm człowieka i skalę zagrożeń dla zdrowia. Przeanalizowano zasady określania wartości dopuszczalnych pola w Polsce i na świecie dla ogółu społeczeństwa i osób pracujących w otoczeniu źródeł pola. Przedstawiono działalność Instytutu Łączności w dziedzinie kompatybilności elektromagnetycznej i pomiarów pola dla celów BHP i ochrony środowiska

Biological evaluation, molecular docking, and sar studies of novel 2-(2,4-dihydroxyphenyl)- 1H- benzimidazole analogues

In the present study, new 4-(1H-benzimidazol-2-yl)-benzene-1,3-diols, modified in both rings, have been synthesized and their efficacies as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors have been determined. The modified Ellman’s spectrophotometric method was applied for the biological evaluation. The compounds showed strong $IC_{50}$ 5-0.2 $\mu$ M AChE and moderate ($IC_{50}$ 5-0.2 M) BuChE inhibition in vitro. Some compounds were e ective toward AChE/BuChE, exhibiting high selectivity ratios versus BuChE, while the other compounds were active against both enzymes. The structure–activity relationships were discussed. The compounds inhibited also in vitro self-induced A$\beta$ (1-42) aggregation and exhibited antioxidant properties. The docking simulations showed that the benzimidazoles under consideration interact mainly with the catalytic site of AChE and mimic the binding mode of tacrine

Epidemiological analysis of hospitalisations due to recurrent stroke in the Silesian Province, Poland, between 2009 and 2015

Background and aim. There is a lack of recent epidemiological studies on recurrent stroke (RS) in Poland. The aim of this study was to analyse all hospitalisations related to RS in Silesia – an industrial region covering 12% of the Polish population.Material and methods. We carried out statistical analysis of data contained in stroke questionnaires transferred to the Polish National Health Fund by hospitals in Silesia, Poland, between 2009 and 2015.Results. In the analysed period, the number of RS hospitalisations in Silesia was 18,063 (22.2% of all acute strokes). The percentage of RS significantly decreased during the period under consideration (p < 0.001). The same observation concerned recurrent ischaemic stroke (RIS), but not recurrent haemorrhagic stroke (RHS). The median hospitalisation time was 14 days for RHS, and 11 days for RIS. Large-artery atherosclerosis and cardioembolisms were significantly more often recognised in RIS than in first-ever ischaemic stroke (FIS) (consecutively, 38.2% vs 36.0%, and 21% vs 18.1%; p < 0.001). The in-hospital mortality rate was significantly higher for RS than for first-ever stroke (18.4% vs 17.2%; p < 0.001). The same observation wasdone for RIS vs FIS (16.2% vs 13.9%; p < 0.001), and for RHS vs FHS (39.8% vs 36%; p = 0.004). The rtPA therapy was applied to 5.3% of FIS and 3.2% of RIS patients (p < 0.001).Conclusions. This is the first such comprehensive and long-term analysis of recurrent stroke in Silesia, Poland. It could help in the implementation of appropriate educational programmes, and thus help to improve the health status of society

Olbrzymia torbiel tętniakowata kości naśladująca nowotwór złośliwy

Torbiel tętniakowata kości (TTK) jest guzem kości, który występuje głównie u młodych dorosłych. Pomimo łagodnego charakteru, czasami jest lokalnie agresywny i może osiągnąć znaczną wielkość. Dlatego nierzadko choroba ta upodabnia się do złośliwego, destrukcyjnego procesu i sprawia trudności diagnostyczne. Przedstawiamy przypadek 12-letniej dziewczynki, u której zauważono gwałtownie rosnącą masę w okolicy stawu biodrowego lewego. W badaniach obrazowych (RTG, MRI, TK) stwierdzono w proksymalnej części kości udowej rozrastającą się zmianę, która uszkadzała warstwę korową kości. Sugerowało to obecność mięśniakomięsaka prążkowanokomórkowego. Zmianę usunięto operacyjnie, wypełniając ubytki kostne przeszczepami. Dwa miesiące po operacji chora zgłosiła dolegliwości bólowe okolicy prawej pachwiny oraz lewego kolana. W badaniu RTG stwierdzono zmiany kostne w prawej kości łonowej oraz lewej udowej. Biopsja nie wykazała zmian patologicznych. W rok od zabiegu operacyjnego zmiany w obrazie RTG prawej kości łonowej oraz lewej kości udowej wycofały się samoistnie. Po 10 latach od rozpoznania torbieli tętniakowatej nie zaobserwowano wznowy choroby ani innych dolegliwości

Diagnostics, treatment and secondary prevention of ischemic stroke in the Silesian Province, Poland between 2009 and 2015

Background The available data on diagnostics and treatment of ischemic stroke (IS) in Poland come mainly from non-representative cohorts or are outdated. Objective Therefore, the current study was done to access the most recent data on IS in the industrial region that covers 12% of the country's population. Materials & methods Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to acute stroke and administered by the National Health Fund (the only public health insurer in Poland) between 2009 and 2015 (n=81,193). Results The number of hospitalizations due to IS in the Silesian Province was 69,403 and constituted 85.5% of all stroke cases reported to the NHF between 2009 and 2015. Neuroimaging of the brain (CT/MRI) was performed in 68,696 (99%) subjects, while ultrasonography of extra- and/or intracranial arteries in 57,886 (83.4%). The rtPA therapy was applied in 3282 patients (4.7% of all IS subjects). The rate of patients treated with rtPA gradually increased (1.2% in 2009, 9.3% in 2015). Among all patients with IS, 57,636 (83.1%) subjects were administered antiplatelet drugs, 16,199 (23.3%) – oral anticoagulants, and 55,971 (80.7%) – antihypertensive drugs. Also, 2260 (3.3%) patients were referred for vascular intervention. In subjects with cardioembolic stroke etiology, 37.8% were treated with anticoagulants. Conclusions There has been observed a significant improvement in the quality of diagnosis and treatment of acute ischemic stroke during recent years. However, further actions are required both in terms of reperfusion treatment (thrombolysis and/or thrombectomy) and secondary prevention of stroke

Characteristics of hospitalizations due to acute stroke in the Silesian Province, Poland, between 2009 and 2015

Introduction The available data on acute stroke (AS) in Poland come mainly from non-representative cohorts or are outdated. Therefore, the current study was done to access the most recent data on AS in the industrial region that covers 12% (4.6mln) of the country's population. Objective To evaluate the epidemiological data of AS in the Silesian Province, Poland. Patients and methods Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to AS and administered by the only public health insurer in Poland (the National Health Fund) between 2009 and 2015 (n=81,193). Results The annual number of hospitalizations due to AS in the analyzed period was between 239 and 259 per 100,000 inhabitants of the Silesian Province. Haemorrhagic stroke constituted 13.3%, ischaemic stroke – 85.5%, and unspecified stroke – 1.2%. The average age of patients was 71.6±12.2 years (M 68.2±11.9, F 74.8±11.9, P<0.05). The mean duration of hospitalization was 17±16 days for haemorrhagic stroke, and 14±11 days for ischaemic stroke. Large-artery atherosclerosis (36.1%) and cardioembolism (18.7%) constituted the main causes of ischaemic stroke. Overall hospital mortality for AS was 18% (haemorrhagic – 40.8%, ischaemic – 14.9%). A decreasing trend in mortality was observed in ischaemic but not in haemorrhagic stroke. In-hospital mortality was significantly higher in women than in men (P<0.05). Conclusions This comprehensive long-term analysis of the epidemiological situation related to AS in the industrial region of Poland should encourage further development of educational and treatment programmes for improvement in the health status of the population

Masked hypertension : a clinical state or measurement bias?

Utajone nadciśnienie tętnicze (MH) to stan, który polega na stwierdzeniu u pacjenta prawidłowych wartości ciśnienia tętniczego w gabinecie lekarskim, a następnie wartości podwyższonych w pomiarach poza gabinetem, na przykład w ambulatoryjnym 24-godzinnym monitorowaniu ciśnienia (ABPM) lub samodzielnych pomiarach domowych. Problem utajonego nadciśnienia tętniczego (termin zaproponowany przez Pickeringa i wsp. w 2002 r.) znany jest od kilku lat. Rozpowszechnienie utajonego nadciśnienia tętniczego, jego przyczyny oraz kryteria rozpoznawania i zasady postępowania nie zostały do końca wyjaśnione. W pracy przedstawiono przegląd możliwych przyczyn występowania tego zjawiska, od problemów metodologicznych po szczególne sytuacje mogące wpływać na podwyższenie się ciśnienia poza gabinetem lekarskim (np. palenie tytoniu, duża aktywność fizyczna). Ponadto przedstawiono przegląd terminologii oraz kryteriów rozpoznawania utajonego nadciśnienia tętniczego, a także poglądów dotyczących jego patogenezy i znaczenia klinicznego. W świetle nowych danych skala występowania utajonego nadciśnienia tętniczego nie pozwala na jego lekceważenie. Wykazano, że u pacjentów z utajonym nadciśnieniem tętniczym częściej stwierdza się powikłania narządowe nadciśnienia tętniczego, takie jak przerost lewej komory serca czy zmiany w tętnicach szyjnych. W celu określenia znaczenia utajonego nadciśnienia tętniczego w codziennej praktyce klinicznej należałoby przeprowadzić prospektywne badania kliniczne w tej grupie pacjentów.Masked hypertension refers to a situation in which a patient has normal blood pressure in the office but elevated elsewhere, for instance in ambulatory blood pressure monitoring (ABPM) or when measured at home. The problem of masked arterial hypertension (the term proposed by Pickering et al. in 2002) has been known for several years. The occurrence of masked hypertension, its causes, criteria of diagnosis and management are not well understood. This paper reviews possible causes of this phenomenon, ranging from methodological issues to specific circumstances that may increase blood pressure outside the office (for instance smoking, high-level physical activity). Furthermore, we review the terminology and criteria of diagnosing masked hypertension, and views on its pathogenesis and clinical implications. New evidence shows that this phenomenon cannot be overlooked. Among patients with masked hypertension those with target organ damage such as left ventricular hypertrophy or carotid arterial lesions are frequently encountered. To define the significance of masked hypertension in everyday clinical practice prospective studies are required

The Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information

The Candida Genome Database (CGD) is a new database that contains genomic information about the opportunistic fungal pathogen Candida albicans. CGD is a public resource for the research community that is interested in the molecular biology of this fungus. CGD curators are in the process of combing the scientific literature to collect all C.albicans gene names and aliases; to assign gene ontology terms that describe the molecular function, biological process, and subcellular localization of each gene product; to annotate mutant phenotypes; and to summarize the function and biological context of each gene product in free-text description lines. CGD also provides community resources, including a reservation system for gene names and a colleague registry through which Candida researchers can share contact information and research interests. CGD is publicly funded (by NIH grant R01 DE15873-01 from the NIDCR) and is freely available at http://www.candidagenome.org/