The measurement of adhesion forces in the system «cell-cell» by using atomic force microscope

The last decades in the world are characterizedby a steady increase in the number of naturaland man-made emergencies. The Republic ofKazakhstan is not an exception to the global patterns ofemergency situations. In the period from September 4 toOctober 6, 2017, a comprehensive study of the state ofhealth of 551 cardiovascular Rescuers in Almaty (Kazakhstan)was carried out according to reports on registereddiseases, their outcomes and causes of temporary disabilityfor 2012-2017, and the need for rehabilitation basedon a specially designed questionnaire. The study showsthe need to develop effective measures for the organizationof medical and psychological rehabilitation of cardiovascularRescuers

Structure of purinergic P2Y12 receptors and some aspects of their biochemistry

The goal of this study is to develop a more rigorous understanding of the P2Y12 receptor first described in blood platelets where it plays a central role in the complex processes of activation and aggregation. P2Y12 receptors are 7-membrane-spanning proteins coupled to G proteins, which are activated by nucleotides, extracellular signaling molecules that are released from damaged cells or secreted via non-lytic mechanisms during inflammatory, ischemic, and hypoxic conditions. It is the drug targets for inhibition of platelet aggregation. We paid attention to structure and properties that provide essential insights for the development of improved P2Y12R ligands and allosteric modulators as drug candidates