52 research outputs found
THE USE OF BACTERIAL LYSATES IN THE COMPLEX TREATMENT OF PATIENTS WITH CHRONIC DECOMPENSATED TONSILLITIS
Introduction. Chronic tonsillitis (CT) occupies a leading place in the structure of general Oto-rhino-laryngology (ORL) pathology which is characterized by a tendency to an increase in the number of patients with recurrent course, the development of complications and the diversity of etiopathogenetic mechanisms of onset. It has been established that the most acceptable tactic for the prevention of exacerbations of chronic tonsillitis is the use of various groups of drugs that enhance the humoral immunity of the mucous membranes. The drug Ismigen is an immunostimulant based on a bacterial lysate, which increases the body's resistance to infections due to an increase in serum and secretory antibodies, activation of cellular and humoral factors of nonspecific immunity. The aim of the study was to evaluate the effectiveness of the use of Ismigen in the complex treatment of patients with chronic decompensated tonsillitis by studying the dynamics of microbiological indicators. Materials and methods. To achieve this goal, 31 patients with chronic decompensated tonsillitis (CDT) were examined. Patients were divided into 2 groups depending on the proposed treatment regimen: Group A: patients with chronic decompensated tonsillitis who underwent laser tonsillotomy - 15 patients; Group B: patients with chronic decompensated tonsillitis who underwent laser tonsillotomy with further immunostimulation with the drug Ismigen - 16 patients. The control group (CG) consisted of 17 practically healthy individual. Patient in group B had sublingual Ismigen postoperatively: once daily for a period for a period of 10 days. Microbiological examination of the material from the mucous membranes of the tonsils or oropharynx was carried out in dynamics before the treatment, 7 days after the treatment and 1-2 months after the end of the course of treatment. A comprehensive assessment of the status of the oropharynx microbiocenosis was carried out in accordance with the criteria described earlier. According to these criteria, the status of the microbiocenosis of the oropharynx was divided into: eubiosis, dysbiosis of the 1st degree, dysbiosis of the 2nd degree and dysbiosis of the 3rd degree. Results and discussion. Before treatment, in the decompensated state of CT (59.7Β±2.8) % of the examined subjects was accompanied by dysbiotic manifestations and were classified to grade 3: 60.0% of patients in group A and in 62.5% of patients in group B. In no case pathology of the tonsils did not reveal the microbiological picture of eubiosis. Carrying out various types of therapeutic measures for patients with CDT positively affected the microbiocenosis status of the studied biotope in comparison with the initial data. Comparison of the results of microbiological examination of patients in groups A and B showed the advantages of using immunocorrection after laser tonsillotomy. Thus, in 81.3% of the examined group B microbiocenoses of the mucous membranes of preserved tonsils are represented by eubiosis, compared with 26.7% in group A (p<0.01). The rest of the patients (18.7%) of group B showed dysbiotic phenomena of 1st degree, against 53.3% of persons in group A (p<0.05). The study of the species composition of the oropharynx microbiota of patients with CDT before treatment and its comparison with bacterial antigens that are part of the preparation of Ismigen showed that practically every patient had persistent one or two respiratory pathogens, which are eliminated by bacterial lysates of Ismigen. Immediately after the treatment, there were no significant differences in the incidence of the above-mentioned bacteria between groups of patients. Respiratory pathogens were detected in 5 patients of group A and 3 patients of group B. The density of seeding of the biotope decreased significantly compared to baseline values and averaged lg (4.1Β±0.2) CFU/g (p <0.01). 1-2 months after the treatment in none of the patients who received the preparation of Β«IsmigenΒ», the indicated bacteria were detected in the microbiocenosis of the mucous tonsils, against 66.7% of the group A patients who did not undergo sublingual immunization (p<0.01) . Β«SanitizingΒ», with respect to the microbial factor of CT, the effectiveness of performed tonsillotomy in a third of patients of group A was lost. The aforementioned respiratory pathogens are most often encountered in chronic inflammatory processes in the upper respiratory tract. Long-term persistence of microorganisms is accompanied by aggravation of immunological disorders and an increased risk of recurrence of the disease [14]. Our studies confirmed the above for patients in Group A, who underwent adequate pathogenetic organ-sparing treatment of the tonsils, but without subsequent immunocorrection. Conclusions. 1. Ismigen, administered to patients with chronic decompensated tonsillitis as part of complex treatment provided a more pronounced antimicrobial effect and promoted restoration of the normocoenosis of the oropharynx. 2. Laser tonsillotomy performed with further immunomodulation with the help of immunostimulant on the basis of bacterial lysates Ismigen, allows to achieve the indices of microbial communities of the mucous membranes of preserved tonsils, which did not differ statistically from the microbiota of the control group of practically healthy persons: in 81.3% of patients, eubiosis and in 18.7% of the dysbiosis of the 1st degree. In persons without pathology of the tonsils, these indicators were 88.2% and 11.8%, respectively. 3. Ismigen has a selective antimicrobial effect against the most common respiratory pathogens, which is objectively manifested by the restoration of the eubiotic colonization profile of the oropharynx in patients with CDT 1-2 months after treatment
THE GENERATION OF CODING SEQUENCES OF CELLULAR GENOME THROUGH COOPTION OF VIRAL GENES
This review attempts to summarize the available data concerning the influence of viruses on the generation of the cellular genome coding genes content. For a long time endogenous retroviruses have been considered as selfish elements of the organism genome. But now there is growing evidence that endogenous retroviruses are more than genome junk and can serve as source for new coding sequences allowing organism evolution. Many genes derived from retroviruses have been identified in eukaryote through comparative genomics and functional analyses. In particular, genes derived from gag structural protein and envelope (env) genes, as well as from the integrase-coding and protease-coding sequences, have been identified in humans and other vertebrates. It has been proved that a number of these genes fulfill essential functions for the development and survival of their host. One of the best known co-opted retroviral genes encoded syncytin plays a key role in the placenta development. It is interesting that during mammalian evolution retroviral envelope genes have been domesticated several times independently to generate syncytin. The activity-regulated cytoskeletal protein Arc is important for cognitive functions and memory formation. Arc was one of over 100 human proteins that have been ββdomesticatedββ from the retrotransposon remains of ancient viruses. A number of genes that code the transcription factors have emerged as a result of βtamingβ the viral genes by the host organism. Now growing evidence reveals that not only retroviruses but other RNA viruses are reverse-transcribed and integrated into the genome of infected cells. It has been recently demonstrated that all Homo sapiens bornavirus like nucleoproteins (EBLN) are expressed in at least one tissue and consequently may have function.The co-option of the viral sequences not only can lead to the major evolutionary innovations, but also is able to create interspecies polymorphism.What it has been described here is probably only the tip of the iceberg, and future genome analyses will certainly uncover new virus-derived genes
Soluble cuticular wax composition and antimicrobial activity of the fruits of Chaenomeles species and an interspecific hybrid
Plants of the genus Chaenomeles Lindl. (Rosaceae) naturally grow in Southeast Asia and represent the richest resource of biologically active compounds with beneficial properties for humans. Plants of C. japonica (Thunb.) Lindl. and C. speciosa (Sweet) Nakai species, and interspecific hybrid C. Γ superba (Frahm) Rehder (C. japonica Γ C. speciosa, Superba group) have been successfully introduced in the steppe zone of Ukraine and bear fruits. In this study, we evaluated chemical composition of fruit cuticular waxes and antimicrobial activity of fruit extracts. The soluble waxes were characterized using gas chromatography-mass spectrometry (GC-MS), and 26β36 compounds, representing 91.7β96.6% of the total soluble cuticular waxes, were identified. Waxes of Chaenomeles fruits belonged to six classes, namely fatty acids, alcohols, aldehydes, esters, ethers and alkanes. Aldehydes 7-hexadecenal and heptacosanal, and alkanes hexatriacontane and tetrapentacontane were the main constituents in the soluble cuticular waxes of C. speciosa and C. Γ superba fruits, accounting for more than half of the total contents. However, alkane tetrapentacontane, alcohol 8,10-hexadecadien-1-ol and heptacosanal prevailed in C. japonica fruit waxes. Isopropanolic fruit extracts exhibited dose-dependent antimicrobial activity against four Gram-negative bacteria, five Gram-positive bacteria and one fungal strain in the disc diffusion assay. In general, extracts from the Chaenomeles fruits demonstrated higher activity against Gram+ bacteria than Gram- strains. The strongest inhibiting activity was shown against Staphylococcus epidermidis (by the fruit extracts of C. Γ superba and C. speciosa), Micrococcus lysodeikticus and Candida albicans (both by C. Γ superba fruit extract). Results of the study confirmed accumulation of the bioactive compounds in the fruit waxes of different Chaenomeles species and antimicrobial ability of Chaenomeles fruits as well. These findings revealed the bioactive compounds in fruit cuticular waxes and suggested health-promoting properties of introduced Chaenomeles species
ΠΠΏΠ»ΠΈΠ² ΡΠΎΠ½ΡΠ² Π²Π°ΠΆΠΊΠΈΡ ΠΌΠ΅ΡΠ°Π»ΡΠ² Ρ ΡΠΈΠ½ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Π½Π° Π΄ΠΈΠ½Π°ΠΌΡΠΊΡ ΡΠΎΡΡΡ Π±Π°ΠΊΡΠ΅ΡΡΠΉ ΡΠΎΠ΄Ρ Pseudomonas
The problem of wastewater treatment is one of the most pressing issues from the beginning of the century. A special roleof the heavy metals in the pollution of the environment is due to their bioaccumulation, transfer through trophic chains, and high toxicity. Currently, advanced technologies for the wastewater treatment had been developed. Natural and cheap biological treatment methods of intensification of the natural processes of organic compounds decomposition by microorganisms under aerobic or anaerobic conditions are promising. Amongimportant processes are nitrification and denitrification. Thatβs why a great attention is paid to the microorganisms that are capable to realize these processes. The processes of interaction of the heavy metals ions and microorganisms are of great interest not only from the standpoint of basic science, but also as a possible use in biotechnological processes.Β ΠΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΎΡΠΈΡΡΠΊΠΈ ΡΡΠΎΡΠ½ΡΡ
Π²ΠΎΠ΄ β ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
Π²ΠΎΠΏΡΠΎΡΠΎΠ² Ρ Π½Π°ΡΠ°Π»Π° Π²Π΅ΠΊΠ°. ΠΡΠΎΠ±ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ ΡΡΠΆΠ΅Π»ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΡΡΠ΅Π΄ΠΈ Π·Π°Π³ΡΡΠ·Π½ΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΈΡ
Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅ ΠΈ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠ΅ΠΉ ΠΏΠΎ ΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΠΏΡΠΌ, ΠΈΡ
Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠΈΡΡΠΊΠΈ ΡΡΠΎΡΠ½ΡΡ
Π²ΠΎΠ΄: ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΈΠΌΠ΅ΡΡ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈ Π΄Π΅ΡΠ΅Π²ΡΠ΅ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΎΡΠΈΡΡΠΊΠΈ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΡΠΎΠ±ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠ°Π·Π»ΠΎΠΆΠ΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°ΠΌΠΈ Π² Π°ΡΡΠΎΠ±Π½ΡΡ
ΠΈΠ»ΠΈ Π°Π½Π°ΡΡΠΎΠ±Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
. ΠΠ΄Π½ΠΈ ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
β ΠΏΡΠΎΡΠ΅ΡΡΡ Π½ΠΈΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ Π΄Π΅Π½ΠΈΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. ΠΠΎΠ»ΡΡΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°ΠΌ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΠΌ Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΡ. ΠΡΠΎΡΠ΅ΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠΎΠ½Π°ΠΌΠΈ ΡΡΠΆΠ΅Π»ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°ΠΌΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ Π±ΠΎΠ»ΡΡΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π΄Π»Ρ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π°ΡΠΊΠΈ, Π° ΠΈ ΠΊΠ°ΠΊ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² Π±ΠΈΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
.Β ΠΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΎΡΠΈΡΠ΅Π½Π½Ρ ΡΡΡΡΠ½ΠΈΡ
Π²ΠΎΠ΄ β ΠΎΠ΄Π½Π΅ Π· Π½Π°ΠΉΠ°ΠΊΡΡΠ°Π»ΡΠ½ΡΡΠΈΡ
ΠΏΠΈΡΠ°Π½Ρ ΡΠ· ΠΏΠΎΡΠ°ΡΠΊΡ ΡΡΠΎΠ»ΡΡΡΡ. ΠΡΠΎΠ±Π»ΠΈΠ²Π΅ ΠΌΡΡΡΠ΅ Π²Π°ΠΆΠΊΠΈΡ
ΠΌΠ΅ΡΠ°Π»ΡΠ² ΡΠ΅ΡΠ΅Π΄ Π·Π°Π±ΡΡΠ΄Π½ΡΠ²Π°ΡΡΠ² Π΄ΠΎΠ²ΠΊΡΠ»Π»Ρ ΠΏΠΎΠ²βΡΠ·Π°Π½Π΅ Π· ΡΡ
Π½Π°ΠΊΠΎΠΏΠΈΡΠ΅Π½Π½ΡΠΌ Π² ΠΎΡΠ³Π°Π½ΡΠ·ΠΌΡ ΡΠ° ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠ΅Ρ ΡΡΠΎΡΡΡΠ½ΠΈΠΌΠΈ Π»Π°Π½ΡΡΠ³Π°ΠΌΠΈ, Π²ΠΈΡΠΎΠΊΠΎΡ ΡΡ
ΡΠΎΠΊΡΠΈΡΠ½ΡΡΡΡ. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΡΡΠ°ΡΠ½Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ ΠΎΡΠΈΡΠ΅Π½Π½Ρ ΡΡΡΡΠ½ΠΈΡ
Π²ΠΎΠ΄: ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²ΠΈ ΠΌΠ°ΡΡΡ ΠΏΡΠΈΡΠΎΠ΄Π½Ρ ΡΠ° Π½Π°ΠΉΠ΄Π΅ΡΠ΅Π²ΡΡ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ ΠΎΡΠΈΡΠ΅Π½Π½Ρ, ΡΠΎ ΡΠ²Π»ΡΡΡΡ ΡΠΎΠ±ΠΎΡ ΡΠ½ΡΠ΅Π½ΡΠΈΡΡΠΊΠ°ΡΡΡ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² ΡΠΎΠ·ΠΊΠ»Π°Π΄Π°Π½Π½Ρ ΠΎΡΠ³Π°Π½ΡΡΠ½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΠΌΡΠΊΡΠΎΠΎΡΠ³Π°Π½ΡΠ·ΠΌΠ°ΠΌΠΈ Π² Π°Π΅ΡΠΎΠ±Π½ΠΈΡ
Π°Π±ΠΎ Π°Π½Π°Π΅ΡΠΎΠ±Π½ΠΈΡ
ΡΠΌΠΎΠ²Π°Ρ
. ΠΠ΄Π½Ρ Π· ΠΎΡΠ½ΠΎΠ²Π½ΠΈΡ
β ΠΏΡΠΎΡΠ΅ΡΠΈ Π½ΡΡΡΠΈΡΡΠΊΠ°ΡΡΡ ΡΠ° Π΄Π΅Π½ΡΡΡΠΈΡΡΠΊΠ°ΡΡΡ. ΠΠ΅Π»ΠΈΠΊΠ° ΡΠ²Π°Π³Π° ΠΏΡΠΈΠ΄ΡΠ»ΡΡΡΡΡΡ ΠΌΡΠΊΡΠΎΠΎΡΠ³Π°Π½ΡΠ·ΠΌΠ°ΠΌ, Π·Π΄Π°ΡΠ½ΠΈΠΌ Π²ΠΈΠΊΠΎΠ½ΡΠ²Π°ΡΠΈ ΡΡ ΠΏΡΠΎΡΠ΅ΡΠΈ. ΠΡΠΎΡΠ΅ΡΠΈ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ ΠΌΡΠΆ ΡΠΎΠ½Π°ΠΌΠΈ Π²Π°ΠΆΠΊΠΈΡ
ΠΌΠ΅ΡΠ°Π»ΡΠ² Ρ ΠΌΡΠΊΡΠΎΠΎΡΠ³Π°Π½ΡΠ·ΠΌΠ°ΠΌΠΈ ΠΌΠ°ΡΡΡ Π²Π΅Π»ΠΈΠΊΠ΅ Π·Π½Π°ΡΠ΅Π½Π½Ρ Π½Π΅ ΡΡΠ»ΡΠΊΠΈ Π΄Π»Ρ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΡ Π½Π°ΡΠΊΠΈ, Π° Ρ ΡΠΊ ΠΌΠΎΠΆΠ»ΠΈΠ²Π΅ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Ρ Π±ΡΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΠ°Ρ
.
ArrayExpress updateβan archive of microarray and high-throughput sequencing-based functional genomics experiments
The ArrayExpress Archive (http://www.ebi.ac.uk/arrayexpress) is one of the three international public repositories of functional genomics data supporting publications. It includes data generated by sequencing or array-based technologies. Data are submitted by users and imported directly from the NCBI Gene Expression Omnibus. The ArrayExpress Archive is closely integrated with the Gene Expression Atlas and the sequence databases at the European Bioinformatics Institute. Advanced queries provided via ontology enabled interfaces include queries based on technology and sample attributes such as disease, cell types and anatomy
The prediction of vascular sheath detachment in making anti-glaucomatous surgeries
The object of this work was to study the preoperative ultrasound criteria, the potentials of predicting vascular sheath detachment in the early postoperative period on the basis of the totality of ultrasound study measurements for anti-glaucomatous surgeries. The case histories of patients, subjected to surgical treatment of glaucoma at State Institution The Kurgan Regional Hospital for War Veterans* in 2007, have been analyzed. As a result, a group of 27 patients with vascular sheath detachment (VSD) in the early operative period has been singled out, as well as a control group of 30 subjects without VSD. The ultrasound study of eyeball has been made in the preoperative period, and in case of vascular membrane thickness increase from 1.0 mm and more, the diameter increase of visual nerve with sheathes from 6.0 mm and more, as well as in case of subchoroidal space visualization, the probability of developing vascular sheath detachment in the early postoperative period is predicted. The application for issue of patent for invention No. 2008123703 (028683) of 10.06.2008.Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΡΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π², Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΠ»ΠΎΠΉΠΊΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ Π² ΡΠ°Π½Π½Π΅ΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ Π°Π½ΡΠΈΠ³Π»Π°ΡΠΊΠΎΠΌΠ½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡΡ
. ΠΡΠ»ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈΡΡΠΎΡΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ
Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π³Π»Π°ΡΠΊΠΎΠΌΡ Π² ΠΠ£ Β«ΠΡΡΠ³Π°Π½ΡΠΊΠΈΠΉ ΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠΉ Π³ΠΎΡΠΏΠΈΡΠ°Π»Ρ Π²Π΅ΡΠ΅ΡΠ°Π½ΠΎΠ² Π²ΠΎΠΉΠ½Β» Π² 2007 Π³ΠΎΠ΄Ρ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π²ΡΠ΄Π΅Π»Π΅Π½Π° Π³ΡΡΠΏΠΏΠ° Π±ΠΎΠ»ΡΠ½ΡΡ
Π² ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅ 27 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ, Ρ ΠΠ‘Π Π² ΡΠ°Π½Π½Π΅ΠΌ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅, ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ Π³ΡΡΠΏΠΏΠ° 30 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Π±Π΅Π· ΠΠ‘Π. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ ΡΠ±Π»ΠΎΠΊΠ° Π² ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΈ ΠΏΡΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠΎΠ»ΡΠΈΠ½Ρ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ ΠΎΡ 1,0 ΠΌΠΌ ΠΈ Π²ΡΡΠ΅, ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ Π΄ΠΈΠ°ΠΌΠ΅ΡΡΠ° Π·ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π΅ΡΠ²Π° Ρ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠ°ΠΌΠΈ ΠΎΡ 6,0 ΠΌΠΌ Π²ΡΡΠ΅ ΠΈ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΡΠ±Ρ
ΠΎΡΠΈΠΎΠΈΠ΄Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π° ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΎΡΡΠ»ΠΎΠΉΠΊΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ Π² ΡΠ°Π½Π½Π΅ΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅. ΠΠ°ΡΠ²ΠΊΠ° ΠΎ Π²ΡΠ΄Π°ΡΠ΅ ΠΏΠ°ΡΠ΅Π½ΡΠ° Π½Π° ΠΈΠ·ΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ β2008123703 (028683) ΠΎΡ 10.06.2008
Mechanical, Electrical and Magnetic Properties of Ferrogels with Embedded Iron Oxide Nanoparticles Obtained by Laser Target Evaporation: Focus on Multifunctional Biosensor Applications
Experiment off diagnostics and treatment of primary cutaneous diffuse large Π-cell lymphoma
The article provides a brief review of the literature about the incidence rate, classification, clinical manifestations, as well as modern methods of diagnostics and treatment of primary cutaneous diffuse large Π-cell lymphomas. Here is also presented a case report.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ, ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΡ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄Π°Ρ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
ΠΊΠΎΠΆΠ½ΡΡ
Π΄ΠΈΡΡΡΠ·Π½ΡΡ
ΠΊΡΡΠΏΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΈΠΌΡΠΎΠΌ. ΠΠΏΠΈΡΠ°Π½ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΡΠ°ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ
ΠΠΠΠ«Π Π’ΠΠ₯ΠΠΠΠΠΠΠ Π Π’ΠΠ₯ΠΠΠ§ΠΠ‘ΠΠΠ Π‘Π ΠΠΠ‘Π’ΠΠ ΠΠΠ― Π£Π’ΠΠΠΠΠΠ¦ΠΠ ΠΠΠΠΠ¨ΠΠΠΠΠ Π’ΠΠΠΠΠΠ«Π₯ ΠΠΠΠΠ’Π ΠΠ‘Π’ΠΠΠ¦ΠΠΜ
The study describes main scientific and practical results obtained when researching new technologies and technical facilities for disposal of ash and slag wastes produced by thermal power plants. The issues of environmental safety provision in the area of thermal power plants are discussed and technologies for magnetic recovery of precious metals from ash and slag wastes are proposed. The data obtained is implemented in methodological documents, technical facilities and introduced into the industry with an economic effect.Β ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π½Π°ΡΡΠ½ΡΠ΅ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈΜ Π½ΠΎΠ²ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈΜ ΠΈ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² Π΄Π»Ρ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ Π·ΠΎΠ»ΠΎΡΠ»Π°ΠΊΠΎΠ² ΡΠ΅ΠΏΠ»ΠΎΠ²ΡΡ
ΡΠ»Π΅ΠΊΡΡΠΎΡΡΠ°Π½ΡΠΈΠΈΜ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²ΠΎΠΏΡΠΎΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΈΜ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΡΠ°ΠΈΜΠΎΠ½ΠΎΠ² ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΠΏΠ»ΠΎΠ²ΡΡ
ΡΠ»Π΅ΠΊΡΡΠΎΡΡΠ°Π½ΡΠΈΠΈΜ ΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠΌΡ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈΠ· ΠΈΡ
Π·ΠΎΠ»ΠΎΡΠ»Π°ΠΊΠΎΠ² ΡΠ΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ². ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠ΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Ρ Π² ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°Ρ
, ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ²Π°Ρ
ΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½Ρ Π² ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΡ Ρ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΡΠ΅ΠΊΡΠΎΠΌ
A case of giant forms of basal cell skin cancer as a result of years of tumoral process and late uptake of patient
The article are contained the publication review about ethiology, pathogenesis, clinical features, diagnostic and treatment methods of basal cell cancer of the skin. Here is also presented case report.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΎΠ± ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΡ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄Π°Ρ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π±Π°Π·Π°Π»ΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΊΠΎΠΆΠΈ. ΠΠΏΠΈΡΠ°Π½ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΡΠ°ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ
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