LogPTR: Variable-Aware Log Parsing with Pointer Network

Due to the sheer size of software logs, developers rely on automated log analysis. Log parsing, which parses semi-structured logs into a structured format, is a prerequisite of automated log analysis. However, existing log parsers are unsatisfactory when applied in practice because: 1) they ignore categories of variables, and 2) have poor generalization ability. To address the limitations of existing approaches, we propose LogPTR, the first end-to-end variable-aware log parser that can extract the static and dynamic parts in logs, and further identify the categories of variables. The key of LogPTR is using pointer network to copy words from the log message. We have performed extensive experiments on 16 public log datasets and the results show that LogPTR outperforms state-of-the-art log parsers both on general log parsing that extracts the log template and variable-aware log parsing that further identifies the category of variables

Enhancing Hydrogen Evolution Electrocatalytic Performance in Neutral Media via Nitrogen and Iron Phosphide Interactions

It remains a challenge to develop efficient electrocatalysts in neutral media for hydrogen evolution reaction (HER) due to the sluggish kinetics and switch of the rate determining step. Although metal phosphides are widely used HER catalysts, their structural stability is an issue due to oxidization, and the HER performance in neutral media requires improvement. Herein, a new material, i.e., grapevine-shaped N-doped iron phosphide on carbon nanotubes, as an efficient HER catalyst in neutral media is developed. The optimized catalyst shows an overpotential of 256 mV at a large current density of 65 mA cm−2, which is even 10 mV lower than that of the commercial 20% Pt/C catalyst. The excellent performance of the catalyst is further studied by combined computational and experimental techniques, which proves that the interaction between nitrogen and iron phosphides can provide more efficient active structures and stabilize the metal phosphide electrocatalysts for HER

Focused ultrasound-mediated brain genome editing.

Gene editing in the brain has been challenging because of the restricted transport imposed by the blood-brain barrier (BBB). Current approaches mainly rely on local injection to bypass the BBB. However, such administration is highly invasive and not amenable to treating certain delicate regions of the brain. We demonstrate a safe and effective gene editing technique by using focused ultrasound (FUS) to transiently open the BBB for the transport of intravenously delivered CRISPR/Cas9 machinery to the brain

From pathogenesis to antigens: the key to shaping the future of TB vaccines

Tuberculosis (TB) remains one of the gravest global health challenges. Mycobacterium tuberculosis (M. tuberculosis), the causative agent, employs sophisticated immune evasion and pathogenesis strategies. Its capability to thrive within immune cells and incite robust inflammatory responses prolongs infection and dissemination. Mycobacterial advanced adaptations facilitate navigation through the human immune system and present a variable antigenic profile throughout different infection stages. Investigating these strategies unfolds targeted approaches to effective vaccine development against TB. This review delves into the most advanced and exhaustive insights into the immune evasion tactics and pathogenic processes of M. tuberculosis across various infection stages. The knowledge distilled from this analysis holds the promise of guiding the creation of innovative TB vaccines and translating theoretical groundwork into practical immunological defenses

An Intelligent Control Method for the Low-Carbon Operation of Energy-Intensive Equipment

Based on an analysis of the operational control behavior of operation experts on energy-intensive equipment, this paper proposes an intelligent control method for low-carbon operation by combining mechanism analysis with deep learning, linking control and optimization with prediction, and integrating decision-making with control. This method, which consists of setpoint control, self-optimized tuning, and tracking control, ensures that the energy consumption per tonne is as low as possible, while remaining within the target range. An intelligent control system for low-carbon operation is developed by adopting the end–edge–cloud collaboration technology of the Industrial Internet. The system is successfully applied to a fused magnesium furnace and achieves remarkable results in reducing carbon emissions

The Effects of Pulse Parameters on Weld Geometry and Microstructure of a Pulsed Laser Welding Ni-Base Alloy Thin Sheet with Filler Wire

Due to its excellent resistance to corrosive environments and its superior mechanical properties, the Ni-based Hastelloy C-276 alloy was chosen as the material of the stator and rotor cans of a nuclear main pump. In the present work, the Hastelloy C-276 thin sheet 0.5 mm in thickness was welded with filler wire by a pulsed laser. The results indicated that the weld pool geometry and microstructure were significantly affected by the duty ratio, which was determined by the pulse duration and repetition rate under a certain heat input. The fusion zone area was mainly affected by the duty ratio, and the relationship was given by a quadratic polynomial equation. The increase in the duty ratio coarsened the grain size, but did not obviously affect microhardness. The weld geometry and base metal dilution rate was manipulated by controlling pulsed parameters without causing significant change to the performance of the weld. However, it should be noted that, with a larger duty ratio, the partial molten zone is a potential weakness of the weld

A study of environmental disclosures practices in Chinese energy industry

In 2016, China increased sustainability practices among companies listed on China's stock market, making environmental regulations one of their integral policies. This states that highly polluting industries like the energy industry are required to comply with the sustainability requirements set. Concerning this event, research was conducted in 2016 to 2017, on the development of environmental disclosure (ED) practices in China and the impact of different variables on environmental disclosure index (EDI). Focusing on 150 energy companies listed on the Shanghai and Shenzhen stock exchange, the findings show that if the company had a better ROA, firm size, leverage and environmental accreditation certificate, they would like to publish more relevant environmental information

Facile construction of diverse diarylmethane scaffolds via uranyl-catalyzed 1,6-addition reaction

A direct 1,6-addition route of p-QMs to synthesize substituted diarylmethanes catalyzed by uranyl ion was developed. In our approach, the salient feature of this transformation is that abundant, underexploited, neglected and sequestrable depleted uranium made the reaction more sustainable. Moreover, diarylmethane derivatives were delivered in moderate to high yields with broad scope and functional group tolerance. Facile operation and mild conditions offer a practical and attractive protocol. (C) 2020 Elsevier Ltd. All rights reserved

Genetic diversity of 23 STR loci of the Guizhou Tujia ethnic minority and the phylogenetic relationships with 22 other populations

Background Short tandem repeats (STR) are highly polymorphic DNA markers utilised in forensic personal identification and human population genetic research. Guizhou Tujia is one of the ancient minority groups in southwest China, however, the population has not been studied using the highly discriminating 23 STR Huaxia Platinum Kit. Aim To obtain genetic data from 23 autosomal STRs in Guizhou Tujia and examine the population’s relationship with others. Subjects and methods A total of 480 individuals from the Guizhou Tujia population were analysed using 23 STR loci of Huaxia Platinum Kit. Allele frequencies and forensic parameters were estimated. Population genetic relationships were calculated by Nei’s genetic distances and visualised using a variety of biostatistical methods. Results A total of 264 alleles were found, with allelic frequencies ranging from 0.0010 to 0.5104. The combined discrimination power (CDP) and the combined probability of paternity (CPE) of 23 STR loci were 0.9999999999999999999999999996 and 0.999999999710422, respectively. Guizhou Tujia showed closer genetic relationships with Hubei Tujia, Guizhou Gelao, and Guizhou Miao than with other populations. Conclusion We first obtained the population genetic data of Guizhou Tujia using the 23 STR system and demonstrated its value in forensic applications. Comprehensive population comparisons showed an evident genetic affinity pattern between populations that are geographically, ethnically and linguistically related

Towards Next-Generation Sequencing for HIV-1 Drug Resistance Testing in a Clinical Setting

The HIV genotypic resistance test (GRT) is a standard of care for the clinical management of HIV/AIDS patients. In recent decades, population or Sanger sequencing has been the foundation for drug resistance monitoring in clinical settings. However, the advent of high-throughput or next-generation sequencing has caused a paradigm shift towards the detection and characterization of low-abundance covert mutations that would otherwise be missed by population sequencing. This is clinically significant, as these mutations can potentially compromise the efficacy of antiretroviral therapy, causing poor virologic suppression. Therefore, it is important to develop a more sensitive method so as to reliably detect clinically actionable drug-resistant mutations (DRMs). Here, we evaluated the diagnostic performance of a laboratory-developed, high-throughput, sequencing-based GRT using 103 archived clinical samples that were previously tested for drug resistance using population sequencing. As expected, high-throughput sequencing found all the DRMs that were detectable by population sequencing. Significantly, 78 additional DRMs were identified only by high-throughput sequencing, which is statistically significant based on McNemar’s test. Overall, our results complement previous studies, supporting the notion that the two methods are well correlated, and the high-throughput sequencing method appears to be an excellent alternative for drug resistance testing in a clinical setting