Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

This systematic review and meta-analysis were conducted to determine the effects of anthraquinone (AQ) laxatives on colorectal cancer (CRC). We searched PubMed, Embase, Google Scholar, and CENTRAL from inception until March 2021, for randomized controlled trials (RCTs) and observational studies. Through the systematic review, we identified 8 observational studies evaluating AQ laxatives use as a risk factor for CRC development, and 5 studies on CRC risk were included in the metaanalysis using a random-effects model. Through the meta-analysis, we found that a history of AQ laxatives use compared with “other” and “no laxatives” use was associated with CRC development (OR: 1.41; 95% CI: 0.94–2.11), although not at a statistically significant level. The possible association persists even after removal of the outlier studies (OR: 1.51; 95% CI: 0.97–2.34). Selection of cases and controls was judged at low or unclear risk of bias across almost all studies, and the quality of evidence was from moderate to low. In conclusion, it is not possible to associate the use of AQ laxatives with the development of CRC. However, the trend toward an increased risk of CRC provides a strong indication for investigating this issue by performing further high-quality studie

Evaporite karst in Italy: a review

Although outcropping rarely in Italy, evaporite (gypsum and anhydrite) karst has been described in detail since the early 20th century. Gypsum caves are now known from almost all Italian regions, but are mainly localised along the northern border of the Apennine chain (Emilia Romagna and Marche), Calabria, and Sicily, where the major outcrops occur. Recently, important caves have also been discovered in the underground gypsum mines in Piedmont. During the late 80s and 90s several multidisciplinary studies were carried out in many gypsum areas, resulting in a comprehensive overview, promoting further research in these special karst regions. More recent and detailed studies focused on the gypsum areas of Emilia-Romagna and Sicily. Sinkholes related to Permian-Triassic gypsum have been studied in Friuli Venezia Giulia. This article reviews the state of the art regarding different aspects of evaporite karst in Italy focusing on the main new results