Investigation of Microstructure and Mechanical Properties of Squeeze Cast LM6 Alloy with Varying Contents of Al 2 O 3 and Si 3 N 4 -A Review

Abstract Aluminum-based composites find its importance in the field of automobile and aerospace industries owing to thei

Tissue-specific histochemical localization of iron and ferritin gene expression in transgenicindica rice Pusa Basmati (Oryza sativa L.)

This article does not have an abstract

Studies on Labour Safety in Construction Sites

Construction industry has accomplished extensive growth worldwide particularly in past few decades. For a construction project to be successful, safety of the structures as well as that of the personnel is of utmost importance. The safety issues are to be considered right from the design stage till the completion and handing over of the structure. Construction industry employs skilled and unskilled labourers subject to construction site accidents and health risks. A proper coordination between contractors, clients, and workforce is needed for safe work conditions which are very much lacking in Indian construction companies. Though labour safety laws are available, the numerous accidents taking place at construction sites are continuing. Management commitment towards health and safety of the workers is also lagging. A detailed literature study was carried out to understand the causes of accidents, preventive measures, and development of safe work environment. This paper presents the results of a questionnaire survey, which was distributed among various categories of construction workers in Kerala region. The paper examines and discusses in detail the total working hours, work shifts, nativity of the workers, number of accidents, and type of injuries taking place in small and large construction sites

Offline Database Access

Most of the People around the globe are not familiar with internet, the reason for inaccessible internet may vary region to region, somewhere because of geographical hurdles but internet has become one of the vital elements of survival for them. In such a scenario, there are parts of the Globe that doesnrsquot receive internet facility, or governmental restrictions.In some places, such as rural areas and remote regions, cell towers and Internet cables simply donrsquot exit. The connectivity will be achieved with the help of remote database access through wireless medium. Once the data has been sent to outernet server we can access it at anytime and anywhere by offline database (Without internet)

COVID-19 and Australia’s mental health: An overview of academic literature, policy documents, lived experience accounts, media and community reports

Over the past 20 months, the COVID-19 pandemic has been a profound disruption to Australians’ daily lives. Many of our daily activities and schedules have changed beyond recognition, including the way we work, go to school, see friends and family, play sport, travel, exercise and engage in hobbies. Economic insecurity and increased job loss have propelled many Australians into financial stress. With the recent Australian outbreak of the Delta Variant, there is widespread uncertainty about what the future will look like. The evidence collated in this synthesis contains important depth and insights, but it is not exhaustive. It draws on a wide-ranging knowledge base including Australian and international published literature, government plans, budgets, policy reports, inquiries, grey literature and public commentary about the mental health and wellbeing impacts of the COVID-19 pandemic, and voices from those who have generously shared their experiences around COVID-19 and mental health. At the time of writing (August/September 2021), NSW, VIC and the ACT are amid another extended lockdown and SA, WA, the NT and QLD have been in-and-out of snap lockdowns, and with a slower than hoped vaccine rollout, there may be more lockdowns and border closures to come

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

We describe the complete synthesis, assembly, debugging, and characterization of a synthetic 404,963 bp chromosome, synIX (synthetic chromosome IX). Combined chromosome construction methods were used to synthesize and integrate its left arm (synIXL) into a strain containing previously described synIXR. We identified and resolved a bug affecting expression of EST3, a crucial gene for telomerase function, producing a synIX strain with near wild-type fitness. To facilitate future synthetic chromosome consolidation and increase flexibility of chromosome transfer between distinct strains, we combined chromoduction, a method to transfer a whole chromosome between two strains, with conditional centromere destabilization to substitute a chromosome of interest for its native counterpart. Both steps of this chromosome substitution method were efficient. We observed that wild-type II tended to co-transfer with synIX and was co-destabilized with wild-type IX, suggesting a potential gene dosage compensation relationship between these chromosomes. </p

Pre-Clinical Evaluation of a Novel Nanoemulsion-Based Hepatitis B Mucosal Vaccine

Hepatitis B virus infection remains an important global health concern despite the availability of safe and effective prophylactic vaccines. Limitations to these vaccines include requirement for refrigeration and three immunizations thereby restricting use in the developing world. A new nasal hepatitis B vaccine composed of recombinant hepatitis B surface antigen (HBsAg) in a novel nanoemulsion (NE) adjuvant (HBsAg-NE) could be effective with fewer administrations.Physical characterization indicated that HBsAg-NE consists of uniform lipid droplets (349+/-17 nm) associated with HBsAg through electrostatic and hydrophobic interactions. Immunogenicity of HBsAg-NE vaccine was evaluated in mice, rats and guinea pigs. Animals immunized intranasally developed robust and sustained systemic IgG, mucosal IgA and strong antigen-specific cellular immune responses. Serum IgG reached > or = 10(6) titers and was comparable to intramuscular vaccination with alum-adjuvanted vaccine (HBsAg-Alu). Normalization showed that HBsAg-NE vaccination correlates with a protective immunity equivalent or greater than 1000 IU/ml. Th1 polarized immune response was indicated by IFN-gamma and TNF-alpha cytokine production and elevated levels of IgG(2) subclass of HBsAg-specific antibodies. The vaccine retains full immunogenicity for a year at 4 degrees C, 6 months at 25 degrees C and 6 weeks at 40 degrees C. Comprehensive pre-clinical toxicology evaluation demonstrated that HBsAg-NE vaccine is safe and well tolerated in multiple animal models.Our results suggest that needle-free nasal immunization with HBsAg-NE could be a safe and effective hepatitis B vaccine, or provide an alternative booster administration for the parenteral hepatitis B vaccines. This vaccine induces a Th1 associated cellular immunity and also may provide therapeutic benefit to patients with chronic hepatitis B infection who lack cellular immune responses to adequately control viral replication. Long-term stability of this vaccine formulation at elevated temperatures suggests a direct advantage in the field, since potential excursions from cold chain maintenance could be tolerated without a loss in therapeutic efficacy