Synthesis and Molecular Docking Studies of N,N-Dimethyl Arylpyranopyrimidinedione Derivatives

AbstractThe synthesis of N,N-dimethyl arylpyranopyrimidinedione derivatives from aromatic aldehydes, N-methyl-1-(methylthio)-2-nitroethamine (NMSM) and 1,3-dimethyl barbituric acid, in the presence of piperidine as a catalyst, is reported. The reaction mechanism involves a Knoevenagel condensation, followed by Michael addition and intramolecular O-cyclization reaction sequence. The synthesized compounds were docked with human kinesin Eg5 protein to calculate binding energy, inhibition constant and H-bond interaction. All the compounds show good binding affinity towards the protein, with significant docking score.</jats:p

Near-Infrared-Emitting Probes for Detection of Nanomolar Hydrazine in a Complete Aqueous Medium with Real-Time Application in Bioimaging and Vapor-Phase Hydrazine Detection

Hydrazine is a highly reactive inorganic compound that is commonly used as a thruster propellant in rocket fuels. In this report, the synthesis of a naphthofluorescein-based simple, sensitive, and selective colorimetric and fluorescent probe for the qualitative and quantitative determination of hydrazine is described. An ultrasensitive NIR probe is employed for the nanomolar detection of hydrazine with real-time applicability. The probe is capable of detecting hydrazine in a completely aqueous medium without the interference of other analytes. The probe reacts selectively with hydrazine and exhibits turn-on NIR emission with quantum yields ranging from Φ = 0.0011 to Φ = 0.5338. This enables the probe to selectively detect extremely low concentrations of hydrazine (∼47 nM). As a consequence, practical utility of the probe is greatly augmented. Eco-friendly test strips were prepared to monitor the hydrazine under aqueous and vapor phases. The potential of the probe was verified by monitoring the presence of hydrazine in a living system by fluorescence bioimaging studies of living cells

Ratiometric Probe for Rapid Naked Eye Detection of Toxic Hydrazine: Real Time Application in Strip Test, Spray Test and Soil Analysis

Abstract Striking colorimetric probe (CynH) for abrupt detection of hydrazine under complete aqueous solution was achieved. The water soluble probe was designed with electron “push-pull” strategy by coupling of 4-hydroxy benzaldehyde and 2, 3, 3-trimethylindolinine. The positively charged N-propylated indolinine make the probe completely soluble in water. The probe yields eye catching selective detection of hydrazine over other competing analytes with high sensitivity. Obvious colour change was observed from colourless to appearance of bright pink colour with hydrazine. It reacts quickly with hydrazine within 2 minutes and makes the probe an effective candidate for practical application. The real time application was demonstrated using paper strip to detect hydrazine vapour. This probe is superior to earlier reported probes because of its effective sensing of hydrazine displayed with various applications including real-time strip based sensing, spray test and soil analysis. In all the examinations, the probe yields distinct response with rapid naked eye colour change this overcomes the drawbacks of previous reports.</jats:p

Synthesis, Characterization and Investigation of the Third Order Nonlinear Optical Properties of Pyrrole Schiff Bases

We have investigated the third order nonlinear optical properties of pyrrole Schiff bases synthesized by condensing pyrrole-2-carboxaldehyde with two different diamines. The nonlinear optical measurements were performed using the nano- second laser pulses at 532nm wavelengthby employing the Z-scan technique. The Z- scan spectra reveal a large negative non-linear refraction co-efficient .The nonlinear refractive index was found to be of the order of 10-14cm2/W and the magnitude of third order susceptibility was of the order of 10-13esu. These compounds exhibit good optical power limiting property under nano-second regime and TPA (Two Photon Absorption) is the dominating process leading to the non-linear behavior.</jats:p