DNA CLEAVAGE ACTIVITY OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES WITH SULFUR CONTAINING-LIGANDS: (2-(2-METHYLTHIO)PHENYLIMINO)METHYLPHENOL, N-BENZYLIDINE-2-METHYLTHIOANILINE

Objective: To study the DNA cleavage activity of all copper(II) complexes using supercoiled pUC19 DNA by agarose gel electrophoresis.Methods: In this study, six new schiff base mixed ligand copper(II) complexes containing [Cu(L1)(8Hq)Cl2], [Cu(L2)(8Hq)Cl],[Cu(L2)(phen)Cl2], [Cu(L1)(Bpy)Cl2], and [Cu(L2)(Bpy)Cl] (where, phen=1,10-phenanthroline, Bpy=2, 2'-bipyridyl, 8Hq=8-hydroxy quinoline, ligandL1=(2-(2-methylthio)phenylimino)methylphenol, ligand L2=N-benzylidine-2-methylthioaniline) were synthesized. The six novel schiff base ligandswere characterized by molar conductance, ultraviolet, infrared (IR), and cyclic voltammetry (CV) measurements. Low molar conductance values ofcopper(II) complexes showed non-electrolyte in nature. The IR spectral data indicate that nitrogen, sulfur, and azomethine nitrogen coordinate to thecentral metal ion. The electrochemical properties such as anodic, cathodic peak potential, and electron transfer process of the complexes were studiedusing CV measurements. Based on these spectral data, octahedral geometry was proposed to all copper(II) complexes.Results: The result confirmed that binding constant value of 13.95 × 1023 M for complex (VI) suggested good intercalative binding with calf thymus(CT) DNA. When DNA (pUC19) cleavage analyses was performed, copper(II) complexes - I, II, V, VI showed cleavage activity.−1Conclusion: The complexes - III and IV did not exhibit DNA binding as well as DNA cleavage potential which may be due to the presence ofO-phenanthroline.Keywords: (2-(2-methylthio)phenylimino)methylphenol, N-benzylidine-2-methylthioaniline, Copper(II) complexes, Calf thymus DNA, pUC19 DNA,DNA binding and cleavage activity.2], [Cu(L1)(phen)Cl

Synthesis and characterization of lanthanide{III) complexes of 1-naphthoxy-, 2-naphthoxy- and 8-quinolinyloxyacetic acids

325-328Lanthanum(III), praseodymium(III), neodymium(Ill), samarium(III), gadolinium(III), terbium(III) and dysprosium(III) chelates of the type [M(RCOO)3].2H2O with the ligands 1-naphthoxy-, 2-naphthoxy- and 8-quinolinyloxyacetic acids have been isolated and characterized on the basis of elemental analyses, spectral, magnetic and thermal data. The IR data show that the bonding of the carboxylato group to the metal ion is bidentate. A coordination number of six is suggested for the rare earth metal ions in these complexes

Synthesis & Characterization of Phenoxyacetates of Lanthanoids

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Synthesis and characterisation of Mn(II), Co(II), Ni(II),Cu(II) and Zn(II) bis- chelates of 8-quinolinyloxyacetic acid and a few mixed ligand complexes of Cu(ll) with 8-quinolinyloxyacetic acid

357-360Manganese(II), cobalt(II), nickel(II) and zinc(II) complexes of the type [M(EHQ)2(H2O)2] and Cu(EHQ)2 with the ligand 8- quinolinyloxyacetic acid(EHQH) have been isolated and characterized on the basis of elemental analyses, spectral, magnetic and thermal data. Copper(Il) mixed ligand complexes of the type [Cu(EHQ)L(H2O)], where LH = 8-hydroxyquinoline(oxineH) /1-acetyl-2-naphtholoxime (OATNOH) /salicylaldehyde phenylhydrazone (SalphH) have also been characterised similarly

Synthesis and characterization of cobalt (II), nickel (II) and copper (II) bis-chelates and mixed-ligand complexes of <img src='/image/spc_char/alpha.gif' border=0>-(2-hydroxyphenyl)-N-( 2-nitrocyclohexyl)nitrone</span>

720-722Complexes of the type MA2.2H2O and CuAL.2H2O [where AH = -(2-hydroxyphenyl)-N-(2-nitrocyclohexyl)nitrone, M= cobalt (II)/ nickel (II)/ copper (II) and LH = salicylaldehyde/salicylaldoximel /8- hydroxyquinoline/2-hydroxypyridine] have been synthesised and characterised on the basis of elemental analysis, spectral, magnetic and thermal studies. All these dihydrates possess normal magnetic moments and their ligand field spectra and thermal studies suggest an octahedral geometry for these complexes

Through-space interaction of sulphur in lanthanide(III) complexes of (phenylthio)acetic acid

754-756The (phenylthio)acetates of lanthanum(III), praseodymium(III ), neodymium(III), samarium(III), gadolinium(III), terbium(III) and dysprosium(III) have been synthesized and characterized by elemental analysis, spectroscopic, magnetic and thermal data. The IR data show that the carboxylato group is bonded to the metal ion in a bidentate chelate mode. A coordination number of seven is suggested for the rare earth metal ions in these complexes. Through-space interaction or sulphur has been suggested for the low M-L covalency in these complexes

Synthesis and stereochemical studies of some 4,4-diethoxycarbonyl-2,6-diaroyl-3,5- diarylthiane-1,1-dioxides

376-377<span style="font-size:16.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">Michael addition of diethyl malonate over 2,2'-sulfonyl-bis(1,3-diarylprop-2-en-1-ones 1a-e in the presence of sodium ethoxide furnish 4,4-diethoxycarbonyl-2,6-diaroyl-3,5-diarylthiane-1,1-dioxides 2a-e in very good yields. The stereochemistry of 2a-e has been deduced from 1H NMR spectroscopic data.</span

Synthesis and characterization of lanthanide(III) complexes of β-benzoyl and α-phenyl-β-benzoyl propionic acids

207-210Synthesis and characterization of lanthanum(III), praseodymium(III), neodymium(III), samarium(III), gadolinium(III),terbium(III), and dysprosium(III) chelates of the type of M {(RCOO)3}2H2O where R=PhCOCH2CH2 and PhCOCH2CHPh are described. The IR data show that the bonding of the carboxylate group to the metal ion is bidendate chelate mode. Coordination number of 6 and 9 is suggested for the rare earth ion in these two series respectively